Nuclear receptors (Homo sapiens)

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1Hepatocyte Nuclear FactorGlucocorticoid ReceptorNuclear Receptor RORProgesterone ReceptorRetinoic Acid Receptor RXRCoup Transcription FactorEstrogen ReceptorOxysterols ReceptorSteroid Hormone ReceptorOrphan ReceptorNuclear receptor TLXNR4 SUPERFAMILYOrphan Nuclear ReceptorAndrogen ReceptorRetinoic Acid ReceptorNR2 SUPERFAMILYPeroxisome ProliferatorActivated ReceptorNR0 SUPERFAMILYVitamin D3 ReceptorNR5 SUPERFAMILYThyroid ReceptorOrphan NuclearReceptorOrphan ReceptorNR3 SUPERFAMILYNR1 SUPERFAMILYSteroidogenic ReceptorTHRAd3 vitaminsOxysterolsPPARGPGRNR5A2retinoicacidRARBNR2F2NR5A1RXRBVDRRORCNR1H2RORAARESRRATHRBPPARDNR4A1RXRGprogesteroneHNF4ANR2C2NR4A2PPARANR1I3THRBPPARGROR1estrogenNR2F1RARGRARANR1D2RARGESRRBNR3C1NR2E1ESR2NR0B1NR1H3ESR1NR2F6NR1I2RXRA


Nuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a liganda molecule which affects the receptor's behavioris present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both embryonic development and adult homeostasis.

Source: Wikipedia (wikipedia:Nuclear_receptor)

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  1. Nagy L, Schule R, Gronemeyer H; ''Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.''; EMBO Rep, 2006 PubMed Europe PMC Scholia


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116552view12:50, 7 May 2021EweitzModified title
106664view21:26, 12 September 2019KhanspersModified description
105759view18:08, 15 August 2019KhanspersModified description
71083view11:57, 3 October 2013EgonwAdded the typical metabolites for some of the receptors.
69977view21:17, 11 July 2013MaintBot
69976view21:17, 11 July 2013MaintBotupdated to 2013 schema
67531view11:21, 26 June 2013DdiglesOntology Term : 'transcription factor mediated signaling pathway' added !
45340view20:22, 7 October 2011Khansperscleaned up description and removed old comment
45337view20:21, 7 October 2011KhanspersModified description
41225view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38864view18:19, 24 September 2010Khanspers
35765view00:09, 13 February 2010AlexanderPicoModified description
35763view00:09, 13 February 2010AlexanderPicoModified description
35476view12:13, 12 February 2010MichielModified description
35473view12:11, 12 February 2010MichielAdded ref
34550view20:14, 21 December 2009KhanspersLayout
31984view13:12, 14 August 2009MaintBotFixed group labels
21037view11:30, 14 November 2008MaintBot[[Pathway:Homo sapiens:Nuclear Receptors]] moved to [[Pathway:WP170]]: Moved to stable identifier
14000view16:15, 20 May 2008Thomasgrouped genes
12973view10:58, 17 May 2008MaintBotSticky edges patch by Sjoerd
8284view13:46, 7 January 2008MaintBot[[Pathway:Human:Nuclear Receptors]] moved to [[Pathway:Homo sapiens:Nuclear Receptors]]: Renaming species
7762view16:16, 18 December 2007MaintBotfixed category names
7434view12:42, 4 November 2007MaintBotAdded categories to GPML
6355view22:18, 22 May 2007E.Tuninskygpml file for [[Human:Nuclear_Receptors]]

External references


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NameTypeDatabase referenceComment
ARGeneProduct367 (Entrez Gene)
ESR1GeneProduct2099 (Entrez Gene)
ESR2GeneProduct2100 (Entrez Gene)
ESRRAGeneProduct2101 (Entrez Gene)
ESRRBGeneProduct2103 (Entrez Gene)
HNF4AGeneProduct3172 (Entrez Gene)
NR0B1GeneProduct190 (Entrez Gene)
NR1D2GeneProduct9975 (Entrez Gene)
NR1H2GeneProduct7376 (Entrez Gene)
NR1H3GeneProduct10062 (Entrez Gene)
NR1I2GeneProduct8856 (Entrez Gene)
NR1I3GeneProduct9970 (Entrez Gene)
NR2C2GeneProduct7182 (Entrez Gene)
NR2E1GeneProduct7101 (Entrez Gene)
NR2F1GeneProduct7025 (Entrez Gene)
NR2F2GeneProduct7026 (Entrez Gene)
NR2F6GeneProduct2063 (Entrez Gene)
NR3C1GeneProduct2908 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NR4A2GeneProduct4929 (Entrez Gene)
NR5A1GeneProduct2516 (Entrez Gene)
NR5A2GeneProduct2494 (Entrez Gene)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGRGeneProduct5241 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
RARAGeneProduct5914 (Entrez Gene)
RARBGeneProduct5915 (Entrez Gene)
RARGGeneProduct5916 (Entrez Gene)
ROR1GeneProduct4919 (Entrez Gene)
RORAGeneProduct6095 (Entrez Gene)
RORCGeneProduct6097 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
RXRBGeneProduct6257 (Entrez Gene)
RXRGGeneProduct6258 (Entrez Gene)
THRAGeneProduct7067 (Entrez Gene)
THRBGeneProduct7068 (Entrez Gene)
VDRGeneProduct7421 (Entrez Gene)
d3 vitaminsMetaboliteCHEBI:73558 (ChEBI)
estrogenMetaboliteCHEBI:50114 (ChEBI)
progesteroneMetaboliteCHEBI:17026 (ChEBI)
retinoic acidMetaboliteCHEBI:26536 (ChEBI)

Annotated Interactions

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