Sterol regulatory element-binding proteins (SREBP) signaling (Homo sapiens)

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ERNucleus3322414, 352615, 17Golgi COPII coated vesicleLipogenic enzymes12LegendPositive effect CleavageCholesterol synthesisCofactorstimulationInhibitionCholesterol effluxCatalysisNegative effectSREUp regulationAMPKExact mechanism unknownTranscription-Translation37PRKAA2nSREBPNFYS1PGlutamineCholesterolPRKAB1ATF6PRKAG3GSK3UFAsPUFAsmiRNA33bHMGCRPRKAG1PRKAG2 LXRmTORC1OxysterolsPRKAA1InsulinCDK8TRC8INSIG1PRKAB2SREBP2AKTRBP4FGF21Glucoseimportin betagp78PKACAMPmiRNA33aSCAPPI3KSIRT1LPIN1394013, 3628316, 42469632, 3824518SCAP10, 237118, 21, 45130472027SCAPINSIG2INSIG1INSIG2SREBP1a,-c25, 31SREBP2SREBP1a,-cSREBP2SREBP1a,-cSAR1ASCAPSREBP2SREBP1a,-cSAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBP1a,-cSAR1BSEC31ASEC31BS2P34SCAPSREBP2SREBP1a,-cnSREBP1a,-cGeneSREnSREBP2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREBSP132NFYCREBSP1YY129, 44YY1PGC-1betaARC1054319ARC105LSSHMGCSMVDIDIFDPSFDFTSQLECYP51A1LPLLDLRSCARB1ACACAGPAFASNDBIACLYMDHPPARGACSSCDFatty aciddegradationFatty acid synthesisSIRT1INSIG114INSIG2SREBP2SREBP1a,-c


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focuses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human.

This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Ontology Terms

 

Bibliography

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  22. Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N; ''Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
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  37. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M; ''AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.''; Cell Metab, 2011 PubMed Europe PMC Scholia
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  39. Irisawa M, Inoue J, Ozawa N, Mori K, Sato R; ''The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
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  45. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMed Europe PMC Scholia
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History

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CompareRevisionActionTimeUserComment
127880view02:01, 6 January 2024EweitzModified description
116442view09:47, 7 May 2021EweitzModified title
110111view12:30, 17 April 2020FehrhartConnected lines and converted graphical lines
106704view13:13, 17 September 2019MaintBotHMDB identifier normalization
105824view23:03, 15 August 2019KhanspersModified description
90425view18:38, 13 November 2016EgonwAdded two references about the cholesterol-SCAP interaction.
90350view13:37, 6 November 2016EgonwFixed weird chars in several references.
86074view08:50, 29 June 2016MirellaKalafatiModified title
79943view09:38, 28 April 2015Zariadded anotation for AMPK
78494view10:28, 7 January 2015MaintBotadded missing graphIds
73382view05:26, 25 January 2014MaintBotremoved newlines from datanode labels
71987view11:08, 24 October 2013MkutmonChanged Unknown -> RNA for miRNA33a
71698view19:46, 17 October 2013MaintBotUpdated UniProt/TrEMBL data source
68403view09:40, 5 July 2013EveloModified description
68402view09:39, 5 July 2013EveloModified description
68401view09:32, 5 July 2013EveloAdded reference for review paper.
67653view11:44, 26 June 2013DdiglesOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
63160view20:19, 8 May 2013MaintBotUpdating gpml version
59430view09:37, 27 February 2013SabinedaemenModified description
59171view18:35, 22 February 2013MaintBotUpdated Ensembl data source
58748view12:15, 20 February 2013Sabinedaemenannotations
58745view09:56, 20 February 2013Sabinedaemenannotations
58744view09:52, 20 February 2013Sabinedaemenannotations
58743view09:01, 20 February 2013Sabinedaemenannotations
58578view10:43, 16 February 2013SabinedaemenModified description
58567view16:25, 15 February 2013Sabinedaemenliterature added
58566view16:21, 15 February 2013Sabinedaemenupdate
58565view10:58, 15 February 2013SabinedaemenRBP4
58564view08:59, 15 February 2013SabinedaemenFGF21
55311view15:16, 13 December 2012SabinedaemenUpdate
55303view15:07, 13 December 2012SabinedaemenPeriodical save, work in progress
55295view14:56, 13 December 2012SabinedaemenPeriodical save, work in progress
55279view14:34, 13 December 2012SabinedaemenPeriodical save, work in progress
55259view14:03, 13 December 2012SabinedaemenPeriodical save, work in progress
55238view13:33, 13 December 2012SabinedaemenPeriodical save, work in progress
54933view07:43, 12 December 2012SabinedaemenUpdate
54932view07:36, 12 December 2012SabinedaemenPeriodical save, work in progress
54929view07:26, 12 December 2012SabinedaemenPeriodical save, work in progress
54928view07:16, 12 December 2012SabinedaemenPeriodical save, work in progress
54927view07:06, 12 December 2012SabinedaemenPeriodical save, work in progress
54795view13:46, 9 December 2012SabinedaemenPeriodical save, work in progress
54794view13:36, 9 December 2012SabinedaemenPeriodical save, work in progress
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54786view12:55, 9 December 2012SabinedaemenPeriodical save, work in progress
54785view12:44, 9 December 2012SabinedaemenPeriodical save, work in progress
54010view11:21, 18 November 2012SabinedaemenmiRNA33
54003view08:58, 18 November 2012Sabinedaemeninsulin-lxr
47598view10:24, 30 March 2012Sabinedaementarget genes list

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSG00000278540 (Ensembl)
ACLYGeneProductENSG00000131473 (Ensembl)
ACSGeneProductENSG00000154930 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ARC105GeneProductENSG00000099917 (Ensembl) activator recruited cofactor (ARC)-mediator activator complex
ATF6GeneProductENSG00000118217 (Ensembl)
CAMPGeneProductENSG00000164047 (Ensembl)
CDK8GeneProductENSG00000132964 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
CYP51A1GeneProductENSG00000001630 (Ensembl)
CholesterolMetaboliteHMDB0000067 (HMDB)
DBIGeneProductENSG00000155368 (Ensembl)
FASNGeneProductENSG00000169710 (Ensembl)
FDFTGeneProductENSG00000079459 (Ensembl)
FDPSGeneProductENSG00000160752 (Ensembl)
FGF21GeneProductENSG00000105550 (Ensembl)
GPAGeneProductENSG00000119927 (Ensembl)
GSK3GeneProductENSG00000105723 (Ensembl)
GlucoseMetaboliteHMDB0000122 (HMDB)
GlutamineMetaboliteHMDB0000641 (HMDB)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCSGeneProductENSG00000112972 (Ensembl)
IDIGeneProductENSG00000067064 (Ensembl)
INSIG1GeneProductENSG00000186480 (Ensembl)
INSIG2GeneProductENSG00000125629 (Ensembl)
InsulinProteinP01308 (Uniprot-TrEMBL)
LDLRGeneProductENSG00000130164 (Ensembl)
LPIN1GeneProductENSG00000134324 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
LSSGeneProductENSG00000160285 (Ensembl)
LXRGeneProductENSG00000131408 (Ensembl)
MDHGeneProductENSG00000014641 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
NFYGeneProductENSG00000001167 (Ensembl)
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PGC-1betaGeneProductENSG00000155846 (Ensembl)
PI3KGeneProductENSG00000121879 (Ensembl)
PKAGeneProductENSG00000072062 (Ensembl)
PPARGGeneProductENSG00000132170 (Ensembl)
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2 GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSG00000138207 (Ensembl)
S1PGeneProductENSG00000140943 (Ensembl)
S2PGeneProductENSG00000012174 (Ensembl)
SAR1AGeneProductENSG00000079332 (Ensembl)
SAR1BGeneProductENSG00000152700 (Ensembl)
SCAPGeneProductENSG00000114650 (Ensembl)
SCARB1GeneProductENSG00000073060 (Ensembl)
SCDGeneProductENSG00000099194 (Ensembl)
SEC13GeneProductENSG00000157020 (Ensembl)
SEC23AGeneProductENSG00000100934 (Ensembl)
SEC23BGeneProductENSG00000101310 (Ensembl)
SEC24AGeneProductENSG00000113615 (Ensembl)
SEC24BGeneProductENSG00000138802 (Ensembl)
SEC24CGeneProductENSG00000176986 (Ensembl)
SEC24DGeneProductENSG00000150961 (Ensembl)
SEC31AGeneProductENSG00000138674 (Ensembl)
SEC31BGeneProductENSG00000075826 (Ensembl)
SIRT1GeneProductENSG00000096717 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
SQLEGeneProductENSG00000104549 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
SREBP1a,-cGeneProductENSG00000072310 (Ensembl)
SREBP2GeneProductENSG00000198911 (Ensembl)
TRC8GeneProductENSG00000170881 (Ensembl)
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSG00000100811 (Ensembl)
gp78GeneProductENSG00000159461 (Ensembl)
importin betaGeneProductENSG00000108424 (Ensembl)
mTORC1GeneProductENSG00000198793 (Ensembl)
miRNA33aRnaMI0000091 (miRBase Sequence)
miRNA33bRnaMI0003646 (miRBase Sequence)
nSREBP1a,-cGeneProductENSG00000072310 (Ensembl)
nSREBP2GeneProductENSG00000198911 (Ensembl)
nSREBPGeneProductENSG00000072310 (Ensembl)

Annotated Interactions

No annotated interactions

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