DON mycotoxin biosynthesis (Gibberella zeae)

From WikiPathways

Jump to: navigation, search
Regulators and associated factorsCatalyst2-HydroxytrichodieneTri114,15-diANIVTri5CatalystCatalystTri4Tri8Tri7 BProductTrichodieneFarnesyl pyrophosphateCatalystCatalystTri101CatalystCatalystTri3Tri13 BTri1CatalystCatalyst1, 3, 512,13-Epoxy-9,10-trichoene-2-olIsotrichotriolIsotrichodiolGeneProductGeneProductTrichotriolIsotrichodermolIsotrichodermin15-decalonectrinCalonectrinTriacetoxyscirpenol7,8-Hydroxy-triacetoxyscirpenol3,15-Diacetylnivalenol8-Hydroxycalonectrin7,8-Dihydroxycalonectrin3,15-Diacetyldeoxynivalenol15-ADONDeoxynivlenolDONNivalenolTri8Tri7 ATri13 ATri6Tri10Tri12Tri12


Description

Gibberella zeae (Fusarium graminearum) is a fungal pathogen of major staple food crops including wheat, maize and rice. The fungus produces a range of mycotoxins including the dexoynivalenol (DON) trichothecene mycotoxin. DON contamination of food crops is a major thread to human and animal health. In wheat, but not in maize, DON was proven to be a virulence factor. Also see Wikipedia article on Vomitoxin.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Desjardins AE, Bai G, Plattner RD, Proctor RH; ''Analysis of aberrant virulence of Gibberella zeae following transformation-mediated complementation of a trichothecene-deficient (Tri5) mutant.''; Microbiology, 2000 PubMed Europe PMC Scholia
  2. Proctor RH, Hohn TM, McCormick SP; ''Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation.''; Microbiology, 1997 PubMed Europe PMC Scholia
  3. Proctor RH, Hohn TM, McCormick SP; ''Restoration of wild-type virulence to Tri5 disruption mutants of Gibberella zeae via gene reversion and mutant complementation.''; Microbiology, 1997 PubMed Europe PMC Scholia
  4. Proctor RH, Hohn TM, McCormick SP; ''Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene.''; Mol Plant Microbe Interact, 1995 PubMed Europe PMC Scholia
  5. ''''; , PubMed Europe PMC Scholia
  6. Desjardins AE, Bai G, Plattner RD, Proctor RH; ''Analysis of aberrant virulence of Gibberella zeae following transformation-mediated complementation of a trichothecene-deficient (Tri5) mutant.''; Microbiology, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106133view12:03, 16 August 2019MaintBotHMDB identifier normalization
84222view13:15, 31 January 2016Martin UrbanModified title
79762view07:05, 10 April 2015EgonwFixed a typo in the case-sensitive "Chemspider" data source name.
74449view05:34, 21 April 2014EgonwFixed PubMed IDs.
72150view10:23, 25 October 2013Mkutmonadded datasource for Tri13 B
71932view20:57, 23 October 2013EgonwAdded missing metabolite identifiers.
70241view21:29, 15 July 2013MaintBotupdated to 2013 schema
67168view10:15, 26 June 2013Christine ChichesterOntology Term : 'deoxynivalenol biosynthetic pathway' added !
52866view19:42, 23 October 2012MaintBotModified categories
52865view19:38, 23 October 2012MaintBotModified description
50698view14:33, 19 August 2012Martin UrbanPeriodical save, work in progress
50697view14:13, 19 August 2012Martin UrbanPeriodical save, work in progress
50696view14:03, 19 August 2012Martin UrbanPeriodical save, work in progress
50581view14:19, 17 August 2012Martin UrbanModified title
50492view17:42, 16 August 2012Martin Urbanupdate02
50491view17:41, 16 August 2012Martin UrbanPeriodical save, work in progress
50490view17:31, 16 August 2012Martin UrbanPeriodical save, work in progress
50489view17:20, 16 August 2012Martin UrbanPeriodical save, work in progress
50488view16:32, 16 August 2012Martin Urbanupdate01
50487view16:28, 16 August 2012Martin UrbanPeriodical save, work in progress
50486view16:18, 16 August 2012Martin UrbanPeriodical save, work in progress
50485view16:08, 16 August 2012Martin UrbanPeriodical save, work in progress
50484view15:57, 16 August 2012Martin UrbanPeriodical save, work in progress
50483view15:47, 16 August 2012Martin UrbanPeriodical save, work in progress
50482view15:36, 16 August 2012Martin UrbanPeriodical save, work in progress
50481view15:26, 16 August 2012Martin UrbanPeriodical save, work in progress
50480view15:16, 16 August 2012Martin UrbanPeriodical save, work in progress
50479view15:05, 16 August 2012Martin UrbanPeriodical save, work in progress
50478view14:54, 16 August 2012Martin UrbanPeriodical save, work in progress
50477view14:44, 16 August 2012Martin UrbanPeriodical save, work in progress
50476view14:34, 16 August 2012Martin UrbanPeriodical save, work in progress
50475view14:06, 16 August 2012Martin UrbanModified description
50474view13:58, 16 August 2012Martin UrbanOntology Term : 'disease pathway' added !
49855view22:14, 28 July 2012MaintBotadded reaction
49852view12:46, 28 July 2012Martin UrbanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12,13-Epoxy-9,10-trichoene-2-olMetabolite
15-ADONMetabolite
15-decalonectrinMetabolite
2-HydroxytrichodieneMetabolite
3,15-DiacetyldeoxynivalenolMetabolite113028 (Chemspider)
3,15-DiacetylnivalenolMetabolite
4,15-diANIVMetabolite
7,8-DihydroxycalonectrinMetabolite484624 (Chemspider)
7,8-Hydroxy-triacetoxyscirpenolMetabolite
8-HydroxycalonectrinMetabolite469583 (Chemspider)
CalonectrinMetabolite9648393 (Chemspider)
CatalystGeneProduct
Deoxynivlenol DONMetabolite
Farnesyl pyrophosphateMetaboliteHMDB0000961 (HMDB)
GeneProductGeneProduct
IsotrichoderminMetabolite110985 (Chemspider)
IsotrichodermolMetabolite165671 (Chemspider)
IsotrichodiolMetabolite
IsotrichotriolMetabolite
NivalenolMetabolite29515 (Chemspider)
ProductMetabolite
Tri101GeneProductFGSG_07896 (Ensembl) TRI101 encodes trichothecene 3-O-acetyltransferase (a self-protection factor)
Tri10GeneProductFGSG_03538 (Ensembl) regulatory prtoein with unknown function
Tri11GeneProductFGSG_03540 (Ensembl)
Tri12GeneProductFGSG_11025 (Ensembl) Zinc finger transcription factor
Tri12GeneProductFGSG_12013 (Ensembl) Membrane-bound efflux pump
Tri13 AGeneProductFGSG_03860 (Ensembl)
Tri13 BGeneProductFGSG_10629 (Ensembl)
Tri1GeneProductFGSG_00071 (Ensembl)
Tri3GeneProductFGSG_03534 (Ensembl) trichothecene 15-O-acetyltransferase
Tri4GeneProductFGSG_03535 (Ensembl) cytochrome P450
Tri5GeneProductFGSG_03537 (Ensembl)
Tri6GeneProductFGSG_16251 (Ensembl) trichothecene biosynthesis positive Zinc finger transcription factor
Tri7 AGeneProductFGSG_02115 (Ensembl)
Tri7 BGeneProductFGSG_03533 (Ensembl)
Tri8GeneProductFGSG_03532 (Ensembl)
TriacetoxyscirpenolMetabolite65844 (Chemspider)
TrichodieneMetaboliteCHEBI:15861 (ChEBI)
TrichotriolMetabolite10204911 (Chemspider)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2258"
Personal tools