miRNA biogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Mature sequence hsa-miR-146a-5p Accession: MIMAT0000449Previous: hsa-miR-146;hsa-miR-146aMature sequence hsa-miR-146a-3pAccession: MIMAT0004608Previous: hsa-miR-146a*Stem-loop sequence hsa-mir-146a Accession: MI0000477 Previous: hsa-mir-1465'3'pri-miRNAsLabelpre-miRNATranscriptionRNA polymerase IINucleusDICER1RANXPO5GTPDROSHADGCR8CytoplasmDICER1TRBPmiRNA duplexDNApre-miRNA5'3'3'5'5'3'5'3'Name: miRNA biogenesisLast Modified: 10/16/2013Organism: Homo sapiens


Description

microRNA biogenesis + an example of a miRBase entry.

As an example immature hsa-mir-146a is shown

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2338).

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngFeatured version

Ontology Terms

 

Bibliography

  1. Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC, Lai EC; ''Widespread regulatory activity of vertebrate microRNA* species.''; RNA, 2011 PubMed Europe PMC Scholia
  2. Wienholds E, Plasterk RH; ''MicroRNA function in animal development.''; FEBS Lett, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137786
Approved
Featured
view06:21, 8 March 2025EgonwModified description
117159view09:46, 18 May 2021EweitzModified title
106710view13:14, 17 September 2019MaintBotHMDB identifier normalization
105861view23:20, 15 August 2019KhanspersModified description
96864view23:59, 14 April 2018AlexanderPicoOntology Term : 'classic metabolic pathway' added !
96863view23:58, 14 April 2018AlexanderPicoswapped datanodes for labels where generic
96862view23:55, 14 April 2018AlexanderPicoconverted all interactions to graphical lines; nothing connecting datanodes
96779view17:25, 5 April 2018Khansperschanged board height
96778view17:25, 5 April 2018Khansperschanged board size
96777view17:23, 5 April 2018Khansperschanged board size
96776view17:13, 5 April 2018Khanspersremoved extra item
96772view12:44, 5 April 2018Marvin M2Updated layout and changed lines into graphical lines
96714view15:38, 29 March 2018Fehrhartconverted interactions to graphical lines
96713view15:34, 29 March 2018Fehrhartconverted interaction to graphical lines
78504view10:29, 7 January 2015MaintBotadded missing graphIds
71236view14:53, 16 October 2013MaintBotAutomated update of data sources
70022view01:52, 12 July 2013AlexanderPicoModified title
68897view17:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
59099view22:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
53823view12:37, 14 November 2012SusanAdding literature
53822view12:33, 14 November 2012SusanModified description
53821view12:32, 14 November 2012SusanOntology Term : 'microRNA pathway' added !
53106view01:11, 30 October 2012MaintBotModified categories
52989view17:36, 25 October 2012SusanNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
DGCR8GeneProductENSG00000128191 (Ensembl)
DICER1GeneProductENSG00000100697 (Ensembl)
DROSHAGeneProductENSG00000113360 (Ensembl)
GTPMetaboliteHMDB0001440 (HMDB)
RANGeneProduct5901 (Entrez Gene)
TRBPProteinQ15633 (Uniprot-TrEMBL)
XPO5GeneProductENSG00000124571 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2338"
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