Parkin-ubiquitin proteasomal system pathway (Homo sapiens)

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1Tubulin alphaUBC626S Proteasome (19S regulator)UBC7HSP70Tubulin betaHSPA8TUBAL3Cullin 1Proteasomal DegradationPSMD8UBCH8UBE2G1Caspase-1UBE2G2UBCH7SEPTIN5PSMD11Cyclin EUBE1TUBB8UBE2J1UBE2J2TUBA4AFBXW7ParkinSynphilin 1CASKCaspase-8CHIPPAELRAlpha-synucleinSIAH1DORFINSIAH2TUBA3ETUBA3DTUBA3CTUBA1CTUBA1BTUBA1ATUBA8TUBA4BTUBB6TUBB4QTUBB4TUBB3TUBB2CTUBB2BTUBB2ATUBB1TUBBPSMD10PSMD1PSMC6PSMC5PSMC4PSMC3PSMC2PSMC1PSMD7PSMD6PSMD5PSMD4PSMD3PSMD2PSMD14PSMD13PSMD12PSMD9HSPA7HSPA6HSPA5HSPA4HSPA2HSPA1LHSPA1BHSPA1AHSPA14HSPA9


Description

This pathway describes the Parkin-Ubiquitin proteasome degradation system.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M; ''Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.''; PLoS One, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
123101view08:56, 3 July 2022EgonwMade a pathway clickable
119918view09:07, 17 September 2021FehrhartUpdated SEPT5 to SEPTIN5 label
118598view15:39, 28 May 2021EweitzModified title
106548view00:11, 6 September 2019KhanspersModified description
105778view19:42, 15 August 2019KhanspersModified description
72121view23:35, 24 October 2013AlexanderPicoadd xref to pathway datanode
72120view23:27, 24 October 2013AlexanderPicotesting tag update
72119view23:26, 24 October 2013AlexanderPicotesting tag update; removed old category
71356view18:35, 17 October 2013MaintBotAutomated update of data sources
68883view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
67576view11:28, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
59316view19:02, 25 February 2013MaintBotModified description
59088view22:07, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57681view20:49, 31 January 2013KhanspersModified categories
53587view19:36, 9 November 2012KhanspersVersion 1 finished
53586view19:33, 9 November 2012KhanspersPeriodical save, work in progress
53585view19:23, 9 November 2012KhanspersPeriodical save, work in progress
53584view19:12, 9 November 2012KhanspersPeriodical save, work in progress
53583view19:02, 9 November 2012KhanspersPeriodical save, work in progress
53544view20:34, 8 November 2012KhanspersAdded lit ref
53543view20:32, 8 November 2012KhanspersPeriodical save
53541view20:21, 8 November 2012KhanspersPeriodical save, work in progress
53540view20:10, 8 November 2012KhanspersPeriodical save, work in progress
53531view19:21, 8 November 2012KhanspersPeriodical save, work in progress
53529view19:10, 8 November 2012KhanspersPeriodical save, work in progress
53466view20:48, 7 November 2012KhanspersNew pathway - first draft
53465view20:44, 7 November 2012KhanspersPeriodical save, work in progress
53464view20:33, 7 November 2012KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Alpha-synucleinGeneProduct6622 (Entrez Gene)
CASKGeneProduct8573 (Entrez Gene)
CHIPGeneProduct10273 (Entrez Gene)
Caspase-1GeneProduct834 (Entrez Gene)
Caspase-8GeneProduct841 (Entrez Gene)
Cullin 1GeneProduct8454 (Entrez Gene)
Cyclin EGeneProduct898 (Entrez Gene)
DORFINGeneProduct25897 (Entrez Gene)
FBXW7GeneProduct55294 (Entrez Gene)
HSPA14GeneProduct51182 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA1BGeneProduct3304 (Entrez Gene)
HSPA1LGeneProduct3305 (Entrez Gene)
HSPA2GeneProduct3306 (Entrez Gene)
HSPA4GeneProduct3308 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA6GeneProduct3310 (Entrez Gene)
HSPA7GeneProductENSG00000225217 (Ensembl)
HSPA8GeneProduct3312 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
PAELRGeneProduct2861 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene)
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD10GeneProduct5716 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD14GeneProduct10213 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD5GeneProduct5711 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
ParkinGeneProduct5071 (Entrez Gene)
Proteasomal DegradationPathwayWP183 (WikiPathways)
SEPTIN5GeneProductENSG00000184702 (Ensembl)
SIAH1GeneProduct6477 (Entrez Gene)
SIAH2GeneProduct6478 (Entrez Gene)
Synphilin 1GeneProduct9627 (Entrez Gene)
TUBA1AGeneProduct7846 (Entrez Gene)
TUBA1BGeneProduct10376 (Entrez Gene)
TUBA1CGeneProduct84790 (Entrez Gene)
TUBA3CGeneProduct7278 (Entrez Gene)
TUBA3DGeneProduct113457 (Entrez Gene)
TUBA3EGeneProduct112714 (Entrez Gene)
TUBA4AGeneProduct7277 (Entrez Gene)
TUBA4BGeneProductENSG00000243910 (Ensembl)
TUBA8GeneProduct51807 (Entrez Gene)
TUBAL3GeneProduct79861 (Entrez Gene)
TUBB1GeneProduct81027 (Entrez Gene)
TUBBGeneProduct203068 (Entrez Gene)
TUBB2AGeneProduct7280 (Entrez Gene)
TUBB2BGeneProduct347733 (Entrez Gene)
TUBB2CGeneProduct10383 (Entrez Gene)
TUBB3GeneProduct10381 (Entrez Gene)
TUBB4GeneProduct10382 (Entrez Gene)
TUBB4QGeneProduct56604 (Entrez Gene)
TUBB6GeneProduct84617 (Entrez Gene)
TUBB8GeneProduct347688 (Entrez Gene)
UBCH7GeneProduct7332 (Entrez Gene)
UBCH8GeneProduct9246 (Entrez Gene)
UBE1GeneProduct7317 (Entrez Gene)
UBE2G1GeneProduct7326 (Entrez Gene)
UBE2G2GeneProduct7327 (Entrez Gene)
UBE2J1GeneProduct51465 (Entrez Gene)
UBE2J2GeneProduct118424 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2359"