Parkin-ubiquitin proteasomal system pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Endoplasmicreticulum26S proteasome (19S regulator)PSMD8PSMD11PSMD10PSMD1PSMC6PSMC5PSMC4PSMC3PSMC2PSMC1PSMD7PSMD6PSMD5PSMD4PSMD3PSMD2PSMD14PSMD13PSMD12PSMD9Tubulin alphaTUBAL3TUBA4ATUBA3ETUBA3DTUBA3CTUBA1CTUBA1BTUBA1ATUBA8TUBA4BTubulin betaTUBB8TUBB6TUBB4QTUBB4TUBB3TUBB2CTUBB2BTUBB2ATUBB1TUBBUBC6UBE2J1UBE2J2UBC7UBE2G1UBE2G2SEPTIN5CASP1UBCH7Proteasomal degradationUBCH8CCNE1UBE1CUL1FBXW7PRKNSNCAIPCASKCASP8CHIPPAELRSNCASIAH1DORFINSIAH2HSP70HSPA8HSPA7HSPA6HSPA5HSPA4HSPA2HSPA1LHSPA1BHSPA1AHSPA14HSPA9Name: Parkin-ubiquitin proteasomal system pathwayOrganism: Homo sapiens


Description

This pathway describes the parkin-ubiquitin proteasome degradation system.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2359)

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access

Ontology Terms

Bibliography

  1. Smith SB, Dampier W, Tozeren A, Brown JR, Magid-Slav M; ''Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis.''; PLoS One, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137886
Approved
view21:02, 9 March 2025EweitzModified description
137885view21:02, 9 March 2025EweitzModified description
137848view14:37, 8 March 2025EweitzRemove obsolete metadata
137847view14:35, 8 March 2025EweitzLabel organelle
137846view14:33, 8 March 2025EweitzFix PathVisio / Kaavio graphical discrepancy
137845view14:32, 8 March 2025EweitzFix layering
137844view14:30, 8 March 2025EweitzUse gene symbols
137843view14:27, 8 March 2025EweitzEconomize layout
137842view14:22, 8 March 2025EweitzEconomize layout
137841view14:19, 8 March 2025EweitzEconomize layout
137840view14:16, 8 March 2025EweitzFix truncated text, standardize case
137839view14:13, 8 March 2025EweitzRefine padding
137838view14:05, 8 March 2025EweitzIncrease font size
137788view06:23, 8 March 2025EgonwModified description
123101view08:56, 3 July 2022EgonwMade a pathway clickable
119918view09:07, 17 September 2021FehrhartUpdated SEPT5 to SEPTIN5 label
118598view15:39, 28 May 2021EweitzModified title
106548view00:11, 6 September 2019KhanspersModified description
105778view19:42, 15 August 2019KhanspersModified description
72121view23:35, 24 October 2013AlexanderPicoadd xref to pathway datanode
72120view23:27, 24 October 2013AlexanderPicotesting tag update
72119view23:26, 24 October 2013AlexanderPicotesting tag update; removed old category
71356view18:35, 17 October 2013MaintBotAutomated update of data sources
68883view17:26, 8 July 2013MaintBotUpdated to 2013 gpml schema
67576view11:28, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
59316view19:02, 25 February 2013MaintBotModified description
59088view22:07, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
57681view20:49, 31 January 2013KhanspersModified categories
53587view19:36, 9 November 2012KhanspersVersion 1 finished
53586view19:33, 9 November 2012KhanspersPeriodical save, work in progress
53585view19:23, 9 November 2012KhanspersPeriodical save, work in progress
53584view19:12, 9 November 2012KhanspersPeriodical save, work in progress
53583view19:02, 9 November 2012KhanspersPeriodical save, work in progress
53544view20:34, 8 November 2012KhanspersAdded lit ref
53543view20:32, 8 November 2012KhanspersPeriodical save
53541view20:21, 8 November 2012KhanspersPeriodical save, work in progress
53540view20:10, 8 November 2012KhanspersPeriodical save, work in progress
53531view19:21, 8 November 2012KhanspersPeriodical save, work in progress
53529view19:10, 8 November 2012KhanspersPeriodical save, work in progress
53466view20:48, 7 November 2012KhanspersNew pathway - first draft
53465view20:44, 7 November 2012KhanspersPeriodical save, work in progress
53464view20:33, 7 November 2012KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CASKGeneProduct8573 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene) "Caspase-1" originally
CASP8GeneProduct841 (Entrez Gene) "Caspase-8" originally
CCNE1GeneProduct898 (Entrez Gene) "Cyclin E" originally
CHIPGeneProduct10273 (Entrez Gene)
CUL1GeneProduct8454 (Entrez Gene) "Cullin 1" originally
DORFINGeneProduct25897 (Entrez Gene)
FBXW7GeneProduct55294 (Entrez Gene)
HSPA14GeneProduct51182 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA1BGeneProduct3304 (Entrez Gene)
HSPA1LGeneProduct3305 (Entrez Gene)
HSPA2GeneProduct3306 (Entrez Gene)
HSPA4GeneProduct3308 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA6GeneProduct3310 (Entrez Gene)
HSPA7GeneProductENSG00000225217 (Ensembl)
HSPA8GeneProduct3312 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
PAELRGeneProduct2861 (Entrez Gene)
PRKNGeneProduct5071 (Entrez Gene) "Parkin" originally
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene)
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD10GeneProduct5716 (Entrez Gene)
PSMD11GeneProduct5717 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD14GeneProduct10213 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD5GeneProduct5711 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
Proteasomal degradationPathwayWP183 (WikiPathways)
SEPTIN5GeneProductENSG00000184702 (Ensembl)
SIAH1GeneProduct6477 (Entrez Gene)
SIAH2GeneProduct6478 (Entrez Gene)
SNCAGeneProduct6622 (Entrez Gene) "Alpha-synuclein" originally
SNCAIPGeneProduct9627 (Entrez Gene) "Synphilin 1" originally
TUBA1AGeneProduct7846 (Entrez Gene)
TUBA1BGeneProduct10376 (Entrez Gene)
TUBA1CGeneProduct84790 (Entrez Gene)
TUBA3CGeneProduct7278 (Entrez Gene)
TUBA3DGeneProduct113457 (Entrez Gene)
TUBA3EGeneProduct112714 (Entrez Gene)
TUBA4AGeneProduct7277 (Entrez Gene)
TUBA4BGeneProductENSG00000243910 (Ensembl)
TUBA8GeneProduct51807 (Entrez Gene)
TUBAL3GeneProduct79861 (Entrez Gene)
TUBB1GeneProduct81027 (Entrez Gene)
TUBBGeneProduct203068 (Entrez Gene)
TUBB2AGeneProduct7280 (Entrez Gene)
TUBB2BGeneProduct347733 (Entrez Gene)
TUBB2CGeneProduct10383 (Entrez Gene)
TUBB3GeneProduct10381 (Entrez Gene)
TUBB4GeneProduct10382 (Entrez Gene)
TUBB4QGeneProduct56604 (Entrez Gene)
TUBB6GeneProduct84617 (Entrez Gene)
TUBB8GeneProduct347688 (Entrez Gene)
UBCH7GeneProduct7332 (Entrez Gene)
UBCH8GeneProduct9246 (Entrez Gene)
UBE1GeneProduct7317 (Entrez Gene)
UBE2G1GeneProduct7326 (Entrez Gene)
UBE2G2GeneProduct7327 (Entrez Gene)
UBE2J1GeneProduct51465 (Entrez Gene)
UBE2J2GeneProduct118424 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2359"
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