Folate biosynthesis (Bacillus subtilis)

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folate2.5.1.155,6,7,8-tetrahydrofolic acid4-Aminobenzoate7,8-dihydropteroic acid4.1.3.384-Amino-4-deoxychorismate2.6.1.85Phenylalaninebiosynthesedihydrofolate reductase6.3.2.17Dihydrofolic acid6.3.2.12(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphatedihydrofolate reductaseChorismate


Pathway describe the folate synthesis.

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Quality Tags

Ontology Terms



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118112view10:57, 24 May 2021EweitzModified title
105913view11:40, 16 August 2019MkutmonHMDB identifier normalization
87506view01:48, 25 July 2016AlexanderPicoOntology Term : 'classic metabolic pathway' added !
87505view01:48, 25 July 2016AlexanderPicoOntology Term : 'folate metabolic pathway' added !
72207view12:00, 27 October 2013EgonwAdded a missing metabolite identifier.
72206view11:59, 27 October 2013EgonwReplaced InChIs and an InChIKey with more traditional identifiers.
71450view19:15, 17 October 2013MaintBotAutomated update of data sources
70670view15:55, 24 August 2013EgonwMinor graphical improvements: larger boxes if things fell out, and new line in long IUPAC name.
69464view19:48, 8 July 2013EgonwExtending the folate biosynthesis pathway.
69463view19:34, 8 July 2013EgonwModified description
68420view18:40, 5 July 2013MaintBotUpdated to 2013 gpml schema
58400view22:07, 12 February 2013MaintBotModified categories
53528view19:02, 8 November 2012Egonw
53527view19:01, 8 November 2012EgonwHa, figured out how to do a reaction with the main reactants.
53526view18:38, 8 November 2012EgonwGrowing...
53508view10:51, 8 November 2012EgonwCorrect organism.
53507view10:40, 8 November 2012EgonwAdded a third metabolite
53506view10:23, 8 November 2012Egonw
53505view10:22, 8 November 2012EgonwNew pathway

External references


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NameTypeDatabase referenceComment
(2-amino-4-hydroxy-7,8-dihydropteridin- 6-yl)methyl trihydrogen diphosphateMetaboliteCHEBI:57602 (ChEBI) (Enzyme Nomenclature) (Enzyme Nomenclature)
4-Amino-4-deoxychorismateMetaboliteCHEBI:35181 (ChEBI)
4-AminobenzoateMetaboliteC00568 (KEGG Compound) (Enzyme Nomenclature)
5,6,7,8-tetrahydrofolic acidMetabolite91443 (PubChem-compound) (Enzyme Nomenclature) (Enzyme Nomenclature)
7,8-dihydropteroic acidMetaboliteCHEBI:4581 (ChEBI)
ChorismateMetaboliteHMDB0012199 (HMDB)
Dihydrofolic acidMetaboliteHMDB0001056 (HMDB)
Phenylalanine biosynthesePathway
dihydrofolate reductaseProtein1.5.1.3 (Enzyme Nomenclature)
folateMetaboliteHMDB0000121 (HMDB)

Annotated Interactions

No annotated interactions

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