Histone modifications (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Histone H3 genesASH1LDOT1LEHMT1EHMT2EZH1EZH2MLLMLL2MLL3MLL5NSD1PRDM2SETSETBP1SETD1ASETD1BSETD2SETD3SETD4SETD5SETD6SETD7SETD8SETD9SETDB1SETDB2SETMARSMYD1SMYD2SMYD3SMYD4SMYD5SUV39H1SUV39H2SUV420H1SUV420H2KMT2BH3F3AH3F3BHIST1H3DHIST1H3JHIST2H3AHIST2H3CHIST2H3DHIST1H3CHIST1H3GHIST1H3HHIST1H3AHIST1H3FHIST1H3BHIST1H3IHIST1H3EK9acH3S10phH3R8ciH3K4me3H3K36me3H3K9me2/3H3K14acH3K18acH3K23acH3K36acH3K27me3H3Histone H3/4 lysine methytransferasesEZH1EZH2EEDAEBP2PRC2-AEBP2PRC2-AEBP2 complexK20me3H4SUV420H1SUV420H2MLLMLL2MLL3KMT2BSETD1ASETD1BCOMPASSCOMPASS complexSUV39H1SUV39H2Clr4 homologsSETD2Suv4-20h homologsK4me1H3K9me1H3K9acH3K27me1H3K27me2H3K79me1/2H3K79me3H3K5acH4K8acH4K12acH4K16acH4K91acH4HIST1H4CHIST1H4HHIST1H4IHIST1H4JHIST4H4HIST1H4KHIST1H4EHIST1H4BHIST1H4LHIST1H4GHIST1H4FHIST1H4DHIST1H4AHistone H4 genesName: Histone modificationsOrganism: Homo sapiens


Description

Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2369)

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:MissingXref.pngAnnotate nodes
Image:Curated.pngApproved version
Image:NonTypical.pngAnnotated lists
Image:Unconnected.pngFix interactions

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T; ''A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  2. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, Shilatifard A; ''COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  3. Rea S, Eisenhaber F, O'Carroll D, Strahl BD, Sun ZW, Schmid M, Opravil S, Mechtler K, Ponting CP, Allis CD, Jenuwein T; ''Regulation of chromatin structure by site-specific histone H3 methyltransferases.''; Nature, 2000 PubMed Europe PMC Scholia
  4. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D; ''Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.''; Genes Dev, 2002 PubMed Europe PMC Scholia
  5. Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD; ''Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.''; Mol Cell Biol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137833
Approved
view13:44, 8 March 2025EweitzAlign interactions
137832view13:43, 8 March 2025EweitzEconomize layout
137792view06:24, 8 March 2025EgonwModified description
128464view21:52, 4 February 2024EweitzRefine layout
128463view21:50, 4 February 2024EweitzFix interactions and layout, standardize case
118380view13:55, 27 May 2021MkutmonRemove unused reference
117753view12:50, 22 May 2021EweitzModified title
106592view19:33, 10 September 2019KhanspersModified description
105616view04:56, 10 August 2019KhanspersModified description
102995view14:38, 31 January 2019Mkutmonupdated outdated ensembl identifier
102992view14:23, 31 January 2019Mkutmonupdated outdated ensembl id
87373view09:56, 22 July 2016MaintBotadded missing graphids
83012view09:44, 17 November 2015LindarieswijkPeriodical save, work in progress
83011view09:37, 17 November 2015LindarieswijkSpecify description
83010view09:35, 17 November 2015LindarieswijkSpecify description
83008view09:33, 17 November 2015LindarieswijkPeriodical save, work in progress
83007view09:26, 17 November 2015LindarieswijkSpecify description
83006view09:25, 17 November 2015LindarieswijkSpecify description
83004view09:24, 17 November 2015LindarieswijkSpecify description
83003view09:23, 17 November 2015LindarieswijkPeriodical save, work in progress
69927view19:51, 11 July 2013AlexanderPicoModified title
62439view23:49, 28 April 2013AlexanderPicoModified description
62438view23:44, 28 April 2013AlexanderPicoModified categories
62437view23:43, 28 April 2013AlexanderPicoOntology Term : 'altered transcription pathway' added !
62436view23:38, 28 April 2013AlexanderPicoRe-added lit refs
62435view23:31, 28 April 2013AlexanderPicoHistone 3 and 4 complete
62434view23:17, 28 April 2013AlexanderPicoH3 done... now H4
62433view22:49, 28 April 2013AlexanderPicoStill working...
62432view22:07, 28 April 2013AlexanderPicoStill working on adding proper datanodes
62431view21:37, 28 April 2013AlexanderPicoModified title
62430view21:36, 28 April 2013AlexanderPicoUpdating datanodes to represent genes and states
62374view00:56, 28 April 2013MaintBotModified title
62373view00:55, 28 April 2013MaintBotModified categories
58693view18:34, 19 February 2013MaintBotModified categories
57673view20:24, 31 January 2013KhanspersModified description
57672view20:24, 31 January 2013KhanspersRemoved comment
54033view20:31, 18 November 2012EgonwAdded some phosphorylation and citrullination.
54024view18:35, 18 November 2012EgonwAdded more observed acetylations
54023view17:23, 18 November 2012EgonwIt all happens in the nucleus. Well, I'm a chemist... :)
54022view17:21, 18 November 2012EgonwAnother useful reference.
54021view17:13, 18 November 2012EgonwAdded a description of this pathway.
54020view17:10, 18 November 2012EgonwAdded a demo catalyst; haven't figured out which does this trimethylation.
54019view17:08, 18 November 2012EgonwOK, one more to the front :(
54018view17:07, 18 November 2012EgonwHopefully fixed the z-order.
54017view17:04, 18 November 2012EgonwAdded a few more possible acetylation sites.
54016view16:56, 18 November 2012EgonwThis reference is general, and not the primary citation for that methylation.
54015view16:54, 18 November 2012EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AEBP2GeneProductENSG00000139154 (Ensembl)
ASH1LGeneProductENSG00000116539 (Ensembl)
DOT1LGeneProductENSG00000104885 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EHMT1GeneProductENSG00000181090 (Ensembl)
EHMT2GeneProduct10919 (Entrez Gene)
EZH1GeneProductENSG00000108799 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
H3Protein
H3F3AGeneProductENSG00000163041 (Ensembl)
H3F3BGeneProductENSG00000132475 (Ensembl)
H4Protein
HIST1H3AGeneProductENSG00000275714 (Ensembl)
HIST1H3BGeneProductENSG00000274267 (Ensembl)
HIST1H3CGeneProductENSG00000278272 (Ensembl)
HIST1H3DGeneProductENSG00000197409 (Ensembl)
HIST1H3EGeneProductENSG00000274750 (Ensembl)
HIST1H3FGeneProductENSG00000277775 (Ensembl)
HIST1H3GGeneProductENSG00000273983 (Ensembl)
HIST1H3HGeneProductENSG00000278828 (Ensembl)
HIST1H3IGeneProductENSG00000275379 (Ensembl)
HIST1H3JGeneProductENSG00000197153 (Ensembl)
HIST1H4AGeneProductENSG00000278637 (Ensembl)
HIST1H4BGeneProductENSG00000278705 (Ensembl)
HIST1H4CGeneProductENSG00000197061 (Ensembl)
HIST1H4DGeneProductENSG00000277157 (Ensembl)
HIST1H4EGeneProductENSG00000276966 (Ensembl)
HIST1H4FGeneProductENSG00000274618 (Ensembl)
HIST1H4GGeneProductENSG00000275663 (Ensembl)
HIST1H4HGeneProductENSG00000158406 (Ensembl)
HIST1H4IGeneProductENSG00000276180 (Ensembl)
HIST1H4JGeneProductENSG00000197238 (Ensembl)
HIST1H4KGeneProductENSG00000273542 (Ensembl)
HIST1H4LGeneProductENSG00000275126 (Ensembl)
HIST2H3AGeneProductENSG00000203852 (Ensembl)
HIST2H3CGeneProductENSG00000203811 (Ensembl)
HIST2H3DGeneProductENSG00000183598 (Ensembl)
HIST4H4GeneProductENSG00000197837 (Ensembl)
KMT2BGeneProductENSG00000272333 (Ensembl)
MLL2GeneProductENSG00000167548 (Ensembl)
MLL3GeneProductENSG00000055609 (Ensembl)
MLL5GeneProductENSG00000005483 (Ensembl)
MLLGeneProductENSG00000118058 (Ensembl)
NSD1GeneProductENSG00000165671 (Ensembl)
PRDM2GeneProductENSG00000116731 (Ensembl)
SETBP1GeneProductENSG00000152217 (Ensembl)
SETD1AGeneProductENSG00000099381 (Ensembl)
SETD1BGeneProductENSG00000139718 (Ensembl)
SETD2GeneProductENSG00000181555 (Ensembl)
SETD3GeneProductENSG00000183576 (Ensembl)
SETD4GeneProductENSG00000185917 (Ensembl)
SETD5GeneProductENSG00000168137 (Ensembl)
SETD6GeneProductENSG00000103037 (Ensembl)
SETD7GeneProductENSG00000145391 (Ensembl)
SETD8GeneProductENSG00000183955 (Ensembl)
SETD9GeneProductENSG00000155542 (Ensembl)
SETDB1GeneProductENSG00000143379 (Ensembl)
SETDB2GeneProductENSG00000136169 (Ensembl)
SETGeneProductENSG00000119335 (Ensembl)
SETMARGeneProductENSG00000170364 (Ensembl)
SMYD1GeneProductENSG00000115593 (Ensembl)
SMYD2GeneProductENSG00000143499 (Ensembl)
SMYD3GeneProductENSG00000185420 (Ensembl)
SMYD4GeneProductENSG00000186532 (Ensembl)
SMYD5GeneProductENSG00000135632 (Ensembl)
SUV39H1GeneProductENSG00000101945 (Ensembl)
SUV39H2GeneProductENSG00000152455 (Ensembl)
SUV420H1GeneProductENSG00000110066 (Ensembl)
SUV420H2GeneProductENSG00000133247 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2369"
Personal tools