Felbamate metabolism (Homo sapiens)

Description

CYP metabolism of felbamate.

View approved pathways at the new wikipathways.org.

Husain Z, Pinto C, Sofia RD, Yunis EJ; ''Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways.''; Epilepsy Res, 2002 PubMed Europe PMC Scholia
Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH; ''Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.''; Clin Pharmacokinet, 1997 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
117724	view	12:34, 22 May 2021	Eweitz	Modified title
106726	view	13:20, 17 September 2019	MaintBot	HMDB identifier normalization
92386	view	18:22, 31 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
88575	view	19:03, 11 August 2016	Mkutmon	fix unconnected lines
76465	view	19:15, 9 July 2014	Khanspers	Ontology Term : 'nervous system drug pathway' added !
75464	view	13:15, 31 May 2014	Egonw	Added a few more steps.
75435	view	15:33, 30 May 2014	Egonw	Added the third known metabolite.
75434	view	15:07, 30 May 2014	Egonw	Added a literature references, supporting KEGG's CYP3A4, rather then DrugBank's CYP3A7.
75433	view	14:32, 30 May 2014	Egonw	Modified description
75432	view	14:31, 30 May 2014	Egonw	New pathway

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Name	Type	Database reference
1.1.1.1	Protein	1.1.1.1 (Enzyme Nomenclature)
1.2.1.5	Protein	1.2.1.5 (Enzyme Nomenclature)
2-hydroxyfelbamate	Metabolite	8575477 (Chemspider)
3-Hydroxy-2-phenylpropyl carbamate	Metabolite	184751 (Chemspider)
3-carbamoyl-2-phenyl propionaldehyde	Metabolite	21350391 (PubChem-compound)
3-carbamoyl-2-phenyl propionic acid	Metabolite	3025746 (PubChem-compound)
CYP2E1	GeneProduct	ENSG00000130649 (Ensembl)
CYP3A4	GeneProduct	ENSG00000160868 (Ensembl)
Felbamate	Metabolite	HMDB0015084 (HMDB)
atropaldehyde	Metabolite	10312 (PubChem-compound)
p-hydroxyfelbamate	Metabolite	8096945 (Chemspider)

No annotated interactions