Endoderm differentiation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusSTAT1NANOGCDYLNME1RFX7RARGFOXN3NAA15MBTD1CTBP2CEBPZWWC1PBX1KDM4ASP4TCF7L1ZNF462MAD2L2AEBP2ASCC3TCEAL2GLI2MIR141 Targets(Induced in Stem Cells)SFMBT1MBTD1LRPPRCTAF4BTAF5FOXO1FOXN3WWC1AEBP2SP4RARGMIR132 Targets(Induced in Stem Cells)UBR5SOX21C1QBPZIC3TRIM71DNMT3BWDHD1JARID2CTBP2MTF2ZIC5AEBP2NCAPG2ZNF281GRHL2TET1MIR375 Targets(Induced in Stem Cells)BTAF1ZFHX4PAX3ZBTB17MIR132 Targets(Induced in Ectoderm)PTHLHEPB41L5LAMC1PRDM14SMAD3RTF1TGFB1NODALBPTFSOX17GATA4HNF1BPAX9LEO1OTX2DAB2SFRP1GDF3NOTCH1HOXA1EXT1PAF1PABPC1EOMESPOU5F1ONECUT1FOXA1NKX2-1CTNNB1TCF7MIXL1CTR9DUSP5SMAD4WNT8AELAVL1CER1FOXA2DKK1APPTNRC6CBMPR1ATBX21SMAD2CAND1BMP7SOX2NOGDUSP4CDC73LEF1HOXC11HHEXGATA6JARID2LHX1MIR653ELK4DIP2APIAS1CRTC1AHDC1PBX3NLKBCORL1ZFHX4MIR375 Targets(Induced in Ectoderm)PLCH1WDFY2SESN1DDAH1PBX1PARP8HPRT1TCF4ACACATRERF1MIR653 Targets(Induced in Stem Cells)WDFY2PARP8RGS10CUL4BSESN1SCHIP1PLCH1TRIM5CEP250PBX1SLC2A12EMSYATP8B2HPRT1VAV3TCF4MIR653 Targets(Induced in Ectoderm)RARGGRHL2ASCC3NABP2ZNF462MBTD1TOXTRERF1MIR373 Targets(Induced in Stem Cells)ZNF462ELP4PHF6TOX3EMSYMIR373 Targets(Induced in Ectoderm)MIR373MIR375MIR141MIR132NR3C1DUSP2EZH2FOXH1SIAH2RAB38APCSOX7MAP2K3WNT3Name: Endoderm differentiationOrganism: Homo sapiens


Description

Model depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from

[www.synapse.org](https://www.synapse.org/#!Synapse:syn1773109).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2853).

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Quality Tags

Image:Featured.pngFeatured version
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

View all...
  1. Chappell, Sun, Singh, Dalton; ''MYC/MAX control ERK signaling and pluripotency by regulation of dual-specificity phosphatases 2 and 7''; Genes Dev, 2013 PubMed Europe PMC Scholia
  2. Tsuneyoshi, Tan, Poobalan, Sumi, Nakatsuji, Suemori, Dunn; ''The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.''; Genes Dev., 2012 PubMed Europe PMC Scholia
  3. Sui, Mfopou, Geens, Sermon, Bouwens; ''FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.''; Biochem Biophys Res Commun., 2012 PubMed Europe PMC Scholia
  4. Kim, Yoon, Chuong, Oyolu, Wills, Gupta, Baker; ''Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs''; Developmental Biology, 2011 PubMed Europe PMC Scholia
  5. Futaki, Hayashi, Emoto, Weber, Sekiguchi; ''Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.''; Mol Cell Biol., 2004 PubMed Europe PMC Scholia
  6. Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP; ''Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.''; Development, 2008 PubMed Europe PMC Scholia
  7. Putzke, Rothman; ''Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.''; Proc Natl Acad Sci USA, 2010 PubMed Europe PMC Scholia
  8. Bourillot, Aksoy, Schreiber, Wianny, Schulz, Hummel, Hubner, Savatier; ''Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.''; Stem Cells, 2009 PubMed Europe PMC Scholia
  9. Kang, Won, Rhee, Ro; ''Siah ubiquitin ligases modulate nodal signaling during zebrafish embryonic development.''; Molecules and Cells, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137822
Featured
Approved
view06:46, 8 March 2025EgonwModified description
116557view12:54, 7 May 2021EweitzModified title
106401view21:32, 28 August 2019KhanspersModified description
105583view04:42, 10 August 2019KhanspersModified description
88152view11:40, 27 July 2016Mkutmonfix invalid uniprot identifiers
88151view11:37, 27 July 2016Mkutmonfix invalid uniprot identifiers
87981view13:20, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
83014view12:38, 17 November 2015FehrhartUpdate of outdated identifiers
80410view23:41, 17 June 2015AlexanderPicoAdded Type information to deficient datanodes
80092view19:38, 6 May 2015Khanspersupdated color for miRNA nodes
79852view03:39, 20 April 2015NsalomonisModified description
79785view15:48, 16 April 2015Mkutmonfixed unconnected line
78496view10:28, 7 January 2015MaintBotadded missing graphIds
77746view20:53, 16 October 2014EgonwFixed two PubMed identifiers.
77718view21:56, 15 October 2014NsalomonisSpecify description
77699view18:17, 10 October 2014NsalomonisSpecify description
77689view18:26, 8 October 2014NsalomonisSpecify description
77683view19:41, 7 October 2014NsalomonisSpecify description
77680view18:26, 7 October 2014NsalomonisNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
ACACAGeneProductQ13085 (Uniprot-TrEMBL)
AEBP2GeneProductQ6ZN18 (Uniprot-TrEMBL)
AHDC1GeneProductQ5TGY3 (Uniprot-TrEMBL)
APCGeneProductENSG00000134982 (Ensembl)
APPGeneProductENSG00000142192 (Ensembl)
ASCC3GeneProductQ8N3C0 (Uniprot-TrEMBL)
ATP8B2GeneProductP98198 (Uniprot-TrEMBL)
BCORL1GeneProductQ5H9F3 (Uniprot-TrEMBL)
BMP7GeneProductENSG00000101144 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BPTFGeneProductENSG00000171634 (Ensembl)
BTAF1GeneProductO14981 (Uniprot-TrEMBL)
C1QBPGeneProductQ07021 (Uniprot-TrEMBL)
CAND1GeneProductENSG00000111530 (Ensembl)
CDC73GeneProductENSG00000134371 (Ensembl)
CDYLGeneProductQ9Y232 (Uniprot-TrEMBL)
CEBPZGeneProductQ03701 (Uniprot-TrEMBL)
CEP250GeneProductQ9BV73 (Uniprot-TrEMBL)
CER1GeneProductENSG00000147869 (Ensembl)
CRTC1GeneProductQ6UUV9 (Uniprot-TrEMBL)
CTBP2GeneProductP56545 (Uniprot-TrEMBL)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTR9GeneProductENSG00000198730 (Ensembl)
CUL4BGeneProductQ13620 (Uniprot-TrEMBL)
DAB2GeneProductENSG00000153071 (Ensembl)
DDAH1GeneProductO94760 (Uniprot-TrEMBL)
DIP2AGeneProductQ14689 (Uniprot-TrEMBL)
DKK1GeneProductENSG00000107984 (Ensembl)
DNMT3BGeneProductQ9UBC3 (Uniprot-TrEMBL)
DUSP2GeneProductENSG00000158050 (Ensembl)
DUSP4GeneProductENSG00000120875 (Ensembl)
DUSP5GeneProductENSG00000138166 (Ensembl)
ELAVL1GeneProductENSG00000066044 (Ensembl)
ELK4GeneProductP28324 (Uniprot-TrEMBL)
ELP4GeneProductQ96EB1 (Uniprot-TrEMBL)
EMSYGeneProductQ7Z589 (Uniprot-TrEMBL)
EOMESGeneProductENSG00000163508 (Ensembl)
EPB41L5GeneProductENSG00000115109 (Ensembl)
EXT1GeneProductENSG00000182197 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOXA1GeneProductENSG00000129514 (Ensembl)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXH1GeneProductENSG00000160973 (Ensembl)
FOXN3GeneProductO00409 (Uniprot-TrEMBL)
FOXO1GeneProductQ12778 (Uniprot-TrEMBL)
GATA4GeneProductENSG00000136574 (Ensembl)
GATA6GeneProductENSG00000141448 (Ensembl)
GDF3GeneProductENSG00000184344 (Ensembl)
GLI2GeneProductP10070 (Uniprot-TrEMBL)
GRHL2GeneProductQ6ISB3 (Uniprot-TrEMBL)
HHEXGeneProductENSG00000152804 (Ensembl)
HNF1BGeneProductENSG00000275410 (Ensembl)
HOXA1GeneProductENSG00000105991 (Ensembl)
HOXC11GeneProductENSG00000123388 (Ensembl)
HPRT1GeneProductP00492 (Uniprot-TrEMBL)
JARID2GeneProductENSG00000008083 (Ensembl)
JARID2GeneProductQ92833 (Uniprot-TrEMBL)
KDM4AGeneProductO75164 (Uniprot-TrEMBL)
LAMC1GeneProductENSG00000135862 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
LEO1GeneProductENSG00000166477 (Ensembl)
LHX1GeneProductENSG00000273706 (Ensembl)
LRPPRCGeneProductP42704 (Uniprot-TrEMBL)
MAD2L2GeneProductQ9UI95 (Uniprot-TrEMBL)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MBTD1GeneProductQ05BQ5 (Uniprot-TrEMBL)
MIR132RnaMIMAT0000426 (miRBase mature sequence)
MIR141GeneProductENSG00000207708 (Ensembl)
MIR373GeneProductENSG00000199143 (Ensembl)
MIR375GeneProductENSG00000198973 (Ensembl)
MIR653GeneProductENSG00000199143 (Ensembl)
MIXL1GeneProductENSG00000185155 (Ensembl)
MTF2GeneProductQ9Y483 (Uniprot-TrEMBL)
NAA15GeneProductQ9BXJ9 (Uniprot-TrEMBL)
NABP2GeneProductQ9BQ15 (Uniprot-TrEMBL)
NANOGGeneProductENSG00000111704 (Ensembl)
NCAPG2GeneProductQ86XI2 (Uniprot-TrEMBL)
NKX2-1GeneProductENSG00000136352 (Ensembl)
NLKGeneProductQ9UBE8 (Uniprot-TrEMBL)
NME1GeneProductP15531 (Uniprot-TrEMBL)
NODALGeneProductENSG00000156574 (Ensembl)
NOGGeneProductENSG00000183691 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NR3C1GeneProductENSG00000113580 (Ensembl)
ONECUT1GeneProductENSG00000169856 (Ensembl)
OTX2GeneProductENSG00000165588 (Ensembl)
PABPC1GeneProductENSG00000070756 (Ensembl)
PAF1GeneProductENSG00000006712 (Ensembl)
PARP8GeneProductQ8N3A8 (Uniprot-TrEMBL)
PAX3GeneProductP23760 (Uniprot-TrEMBL)
PAX9GeneProductENSG00000198807 (Ensembl)
PBX1GeneProductP40424 (Uniprot-TrEMBL)
PBX3GeneProductP40426 (Uniprot-TrEMBL)
PHF6GeneProductQ8IWS0 (Uniprot-TrEMBL)
PIAS1GeneProductO75925 (Uniprot-TrEMBL)
PLCH1GeneProductQ4KWH8 (Uniprot-TrEMBL)
POU5F1GeneProductENSG00000204531 (Ensembl)
PRDM14GeneProductENSG00000147596 (Ensembl)
PTHLHGeneProductENSG00000087494 (Ensembl)
RAB38GeneProductENSG00000123892 (Ensembl)
RARGGeneProductP13631 (Uniprot-TrEMBL)
RFX7GeneProductQ2KHR2 (Uniprot-TrEMBL)
RGS10GeneProductO43665 (Uniprot-TrEMBL)
RTF1GeneProductENSG00000137815 (Ensembl)
SCHIP1GeneProductQ9P0W5 (Uniprot-TrEMBL)
SESN1GeneProductQ9Y6P5 (Uniprot-TrEMBL)
SFMBT1GeneProductQ9UHJ3 (Uniprot-TrEMBL)
SFRP1GeneProductENSG00000104332 (Ensembl)
SIAH2GeneProductENSG00000181788 (Ensembl)
SLC2A12GeneProductQ8TD20 (Uniprot-TrEMBL)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX21GeneProductQ9Y651 (Uniprot-TrEMBL)
SOX2GeneProductENSG00000181449 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
SP4GeneProductQ02446 (Uniprot-TrEMBL)
STAT1GeneProductENSG00000115415 (Ensembl)
TAF4BGeneProductQ92750 (Uniprot-TrEMBL)
TAF5GeneProductQ15542 (Uniprot-TrEMBL)
TBX21GeneProductENSG00000073861 (Ensembl)
TCEAL2GeneProductQ9H3H9 (Uniprot-TrEMBL)
TCF4GeneProductP15884 (Uniprot-TrEMBL)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductQ9HCS4 (Uniprot-TrEMBL)
TET1GeneProductQ8NFU7 (Uniprot-TrEMBL)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNRC6CGeneProductENSG00000078687 (Ensembl)
TOX3GeneProductO15405 (Uniprot-TrEMBL)
TOXGeneProductO94900 (Uniprot-TrEMBL)
TRERF1GeneProductQ96PN7 (Uniprot-TrEMBL)
TRIM5GeneProductQ9C035 (Uniprot-TrEMBL)
TRIM71GeneProductQ2Q1W2 (Uniprot-TrEMBL)
UBR5GeneProductO95071 (Uniprot-TrEMBL)
VAV3GeneProductQ9UKW4 (Uniprot-TrEMBL)
WDFY2GeneProductQ96P53 (Uniprot-TrEMBL)
WDHD1GeneProductO75717 (Uniprot-TrEMBL)
WNT3GeneProductENSG00000108379 (Ensembl)
WNT8AGeneProductENSG00000061492 (Ensembl)
WWC1GeneProductQ8IX03 (Uniprot-TrEMBL)
ZBTB17GeneProductQ13105 (Uniprot-TrEMBL)
ZFHX4GeneProductQ86UP3 (Uniprot-TrEMBL)
ZIC3GeneProductO60481 (Uniprot-TrEMBL)
ZIC5GeneProductQ96T25 (Uniprot-TrEMBL)
ZNF281GeneProductQ9Y2X9 (Uniprot-TrEMBL)
ZNF462GeneProductQ96JM2 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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