Ectoderm differentiation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusPAX6 targetsASTN1CLVS1GRAMD1BDMDKCNK10NLKZFHX4NARS2GLB1PI4KARGMAELOVL4TOX3SMAD4MIR34CMIR486FOXL1MIR361TRIM33MIR15BSCHIP1PPARDFOXA2SNCAPAX6PAX3ARHGAP15GLI3SHHCTNNB1WNT1OGTNR2F2BOCPAN2CTBP1CCDC88CHDAC10VAX2ARHGEF9CTNNA2JUPMKS1CCDC130SGSM3SDCBPEDAFGFR2KRT6AHMGB2CTNND2ZBTB16CDH6TSC22D1CDH8NUMA1LHX1TCF3ZBTB7BTTC14RAB8BNF2NLKNLGN1EDA2RPTPN13AHI1ZFHX4FYNPDE7ACDONRIT1SMURF1TBL1XHDAC6BMP4BMPR1AZBTB2HIST1H2BHMYCMIR34C targets(induced in endoderm)TSKUPGM1PLCXD3FZD4ROR2CCL2TNFRSF11BGAS2L1ANKS1BC1GALT1RRBP1WDR44KIFC3PTPRBARHGDIGPOU2F2PODXLELOVL2SORCS1LY6EST8SIA4SERPINB6AESNFATC1ABCC4MIR124 targets(induced in mesoderm)LDB2UBTFZBTB2MYCMIR34C targets(induced in stem cells)PPFIBP2FZD8GATA6CLDN11SPRY2FZD5PLXNA2STC1JAKMIP1ARHGDIGEDATRPM2KIAA1161SOCS2MIR124 targets(induced in endoderm)PIM1BAZ1ASKILZBTB2ZNF219MECP2PHF8MZF1ARXAdditional predicted key ectoderm TFsCELSR2BCAS3GREB1PRKAG2RHPN1STX16CROCCP2CAP2TFAP2C targetsTCF7L1HESX1SIX6ARHGAP10MAFBTFAP2CMIR124-1SOX2TFAP2AZBTB2FHL2SKILBCORMIR15B targets(induced in stem cells)MIR15B targets(induced in endoderm)MesoderminductionName: Ectoderm differentiationOrganism: Homo sapiens


Description

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from [www.synapse.org](https://www.synapse.org/#!Synapse:syn1773109). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2858).

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Quality Tags

Image:Featured.pngFeatured version
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

View all...
  1. ''HESX1- and TCF3-mediated repression of Wnt/خ²-catenin targets is required for normal development of the anterior forebrain''; , PubMed Europe PMC Scholia
  2. ''Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway.''; , PubMed Europe PMC Scholia
  3. ''Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis''; , PubMed Europe PMC Scholia
  4. ''Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from embryonic stem cells.''; , PubMed Europe PMC Scholia
  5. ''Beyond cell adhesion: the role of armadillo proteins in the heart.''; , PubMed Europe PMC Scholia
  6. ''Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.''; , PubMed Europe PMC Scholia
  7. ''Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development''; , PubMed Europe PMC Scholia
  8. ''Hedgehog and Gli signaling in embryonic mammary gland development.''; , PubMed Europe PMC Scholia
  9. Van Hateren, N., Shenton, T., Borycki, A.-G; ''Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development ''; , 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137826
Featured
Approved
view06:48, 8 March 2025EgonwModified description
128355view13:49, 2 February 2024EweitzStandardize case
116763view09:40, 12 May 2021EweitzModified title
110690view13:46, 28 May 2020Marvin M2changed unknown type to geneproduct
110689view13:43, 28 May 2020Marvin M2Changed unknown nodes to geneproducts
106397view21:30, 28 August 2019KhanspersModified description
105577view06:31, 9 August 2019KhanspersModified description
94911view00:00, 13 October 2017Khanspersconnected interactions
94753view15:29, 5 October 2017Mkutmonfix unconnected line
89329view09:53, 4 September 2016Mkutmonfix unconnected lines
87931view13:02, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
83015view13:26, 17 November 2015FehrhartUpdate of outdated identifiers
80104view21:49, 6 May 2015Khansperschanged color for miRNA nodes
80017view17:25, 30 April 2015ZariCorrected ID for BAZ1A,SKIL,ZBTB2,PIM1 ,MYC,LDB2,UBTF,HIST1H2BH,FHL2,BCOR
79851view03:37, 20 April 2015NsalomonisModified description
78578view14:50, 7 January 2015MaintBotadded missing graphIds
77751view05:03, 17 October 2014EgonwFixed two PubMed identifiers.
77745view20:49, 16 October 2014EgonwMade the PubMed identifiers proper numbers.
77686view03:48, 8 October 2014NsalomonisNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
ABCC4GeneProductENSG00000125257 (Ensembl)
AESGeneProductENSG00000104964 (Ensembl)
AHI1GeneProductENSG00000135541 (Ensembl)
ANKS1BGeneProductENSG00000185046 (Ensembl)
ARHGAP10GeneProductENSG00000071205 (Ensembl)
ARHGAP15GeneProductENSG00000075884 (Ensembl)
ARHGDIGGeneProductENSG00000242173 (Ensembl)
ARHGEF9GeneProductENSG00000131089 (Ensembl)
ARXGeneProductENSG00000004848 (Ensembl)
ASTN1GeneProductENSG00000152092 (Ensembl)
BAZ1AGeneProduct11177 (Entrez Gene)
BCAS3GeneProductENSG00000141376 (Ensembl)
BCORGeneProduct54880 (Entrez Gene)
BMP4GeneProductENSG00000125378 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BOCGeneProductENSG00000144857 (Ensembl)
C1GALT1GeneProductENSG00000106392 (Ensembl)
CAP2GeneProductENSG00000112186 (Ensembl)
CCDC130GeneProductENSG00000104957 (Ensembl)
CCDC88CGeneProductENSG00000015133 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CDH6GeneProductENSG00000113361 (Ensembl)
CDH8GeneProductENSG00000150394 (Ensembl)
CDONGeneProductENSG00000064309 (Ensembl)
CELSR2GeneProductENSG00000143126 (Ensembl)
CLDN11GeneProductENSG00000013297 (Ensembl)
CLVS1GeneProductENSG00000177182 (Ensembl)
CROCCP2GeneProductENSG00000215908 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTNND2GeneProductENSG00000169862 (Ensembl)
DMDGeneProductENSG00000198947 (Ensembl)
EDA2RGeneProductENSG00000131080 (Ensembl)
EDAGeneProductENSG00000158813 (Ensembl)
ELOVL2GeneProductENSG00000197977 (Ensembl)
ELOVL4GeneProductENSG00000118402 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FHL2GeneProduct2274 (Entrez Gene)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXL1GeneProductENSG00000176678 (Ensembl)
FYNGeneProductENSG00000010810 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
GAS2L1GeneProductENSG00000185340 (Ensembl)
GATA6GeneProductENSG00000141448 (Ensembl)
GLB1GeneProductENSG00000170266 (Ensembl)
GLI3GeneProductENSG00000106571 (Ensembl)
GRAMD1BGeneProductENSG00000023171 (Ensembl)
GREB1GeneProductENSG00000196208 (Ensembl)
HDAC10GeneProductENSG00000100429 (Ensembl)
HDAC6GeneProductENSG00000094631 (Ensembl)
HESX1GeneProductENSG00000163666 (Ensembl)
HIST1H2BHGeneProduct8345 (Entrez Gene)
HMGB2GeneProductENSG00000164104 (Ensembl)
JAKMIP1GeneProductENSG00000152969 (Ensembl)
JUPGeneProductENSG00000173801 (Ensembl)
KCNK10GeneProductENSG00000100433 (Ensembl)
KIAA1161GeneProductENSG00000164976 (Ensembl)
KIFC3GeneProductENSG00000140859 (Ensembl)
KRT6AGeneProductENSG00000205420 (Ensembl)
LDB2GeneProduct9079 (Entrez Gene)
LHX1GeneProductENSG00000273706 (Ensembl)
LY6EGeneProductENSG00000160932 (Ensembl)
MAFBGeneProductENSG00000204103 (Ensembl)
MECP2GeneProductENSG00000169057 (Ensembl)
MIR124-1RnaMIMAT0000422 (miRBase mature sequence)
MIR15BGeneProductENSG00000207779 (Ensembl)
MIR34CGeneProductENSG00000207562 (Ensembl)
MIR361GeneProductENSG00000199051 (Ensembl)
MIR486RnaMIMAT0002177 (miRBase mature sequence)
MKS1GeneProductENSG00000011143 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
MZF1GeneProductENSG00000099326 (Ensembl)
NARS2GeneProductENSG00000137513 (Ensembl)
NF2GeneProductENSG00000186575 (Ensembl)
NFATC1GeneProductENSG00000131196 (Ensembl)
NLGN1GeneProductENSG00000169760 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NR2F2GeneProductENSG00000185551 (Ensembl)
NUMA1GeneProductENSG00000137497 (Ensembl)
OGTGeneProductENSG00000147162 (Ensembl)
PAN2GeneProductENSG00000135473 (Ensembl)
PAX3GeneProductENSG00000135903 (Ensembl)
PAX6GeneProductENSG00000007372 (Ensembl)
PDE7AGeneProductENSG00000205268 (Ensembl)
PGM1GeneProductENSG00000079739 (Ensembl)
PHF8GeneProductENSG00000172943 (Ensembl)
PI4KAGeneProductENSG00000241973 (Ensembl)
PIM1GeneProduct5292 (Entrez Gene)
PLCXD3GeneProductENSG00000182836 (Ensembl)
PLXNA2GeneProductENSG00000076356 (Ensembl)
PODXLGeneProductENSG00000128567 (Ensembl)
POU2F2GeneProductENSG00000028277 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPFIBP2GeneProductENSG00000166387 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PTPN13GeneProductENSG00000163629 (Ensembl)
PTPRBGeneProductENSG00000127329 (Ensembl)
RAB8BGeneProductENSG00000166128 (Ensembl)
RGMAGeneProductENSG00000182175 (Ensembl)
RHPN1GeneProductENSG00000158106 (Ensembl)
RIT1GeneProductENSG00000143622 (Ensembl)
ROR2GeneProductENSG00000169071 (Ensembl)
RRBP1GeneProductENSG00000125844 (Ensembl)
SCHIP1GeneProductENSG00000151967 (Ensembl)
SDCBPGeneProductENSG00000137575 (Ensembl)
SERPINB6GeneProductENSG00000124570 (Ensembl)
SGSM3GeneProductENSG00000100359 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SIX6GeneProductENSG00000184302 (Ensembl)
SKILGeneProduct6498 (Entrez Gene)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMURF1GeneProductENSG00000198742 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
SOCS2GeneProductENSG00000120833 (Ensembl)
SORCS1GeneProductENSG00000108018 (Ensembl)
SOX2GeneProductENSG00000181449 (Ensembl)
SPRY2GeneProductENSG00000136158 (Ensembl)
ST8SIA4GeneProductENSG00000113532 (Ensembl)
STC1GeneProductENSG00000159167 (Ensembl)
STX16GeneProductENSG00000124222 (Ensembl)
TBL1XGeneProductENSG00000101849 (Ensembl)
TCF3GeneProductENSG00000071564 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TFAP2AGeneProductENSG00000137203 (Ensembl)
TFAP2CGeneProductENSG00000087510 (Ensembl)
TNFRSF11BGeneProductENSG00000164761 (Ensembl)
TOX3GeneProductENSG00000103460 (Ensembl)
TRIM33GeneProductENSG00000197323 (Ensembl)
TRPM2GeneProductENSG00000142185 (Ensembl)
TSC22D1GeneProductENSG00000102804 (Ensembl)
TSKUGeneProductENSG00000182704 (Ensembl)
TTC14GeneProductENSG00000163728 (Ensembl)
UBTFGeneProduct7343 (Entrez Gene)
VAX2GeneProductENSG00000116035 (Ensembl)
WDR44GeneProductENSG00000131725 (Ensembl)
WNT1GeneProductENSG00000125084 (Ensembl)
ZBTB16GeneProductENSG00000109906 (Ensembl)
ZBTB2GeneProduct57621 (Entrez Gene)
ZBTB7BGeneProductENSG00000160685 (Ensembl)
ZFHX4GeneProductENSG00000091656 (Ensembl)
ZNF219GeneProductENSG00000165804 (Ensembl)

Annotated Interactions

No annotated interactions

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