NRF2 pathway (Homo sapiens)

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21DegradationTranscriptionPhase 1 proteinsTransportAntioxidant proteinsPhase 2 proteinsOtherGrowth factor and receptorsTranscription Factors1616161616161616LigandSLC2A1CES3ME1PRDX1GSTA1SLC2A11GPX27HGFUGT1A41FGF13BLVRBGCLCMGST3SLC7A11NFE2L2GSTA3SLC2A13ABCC2TXNABCC4SOD3SLC2A9GPX3ADH7EPHA3GSRHSP90AB1GSTT1SLC2A7SLC2A14SRXN1UGT1A7PGD1CBR1ALDH3A1CYP2A6PPARDCBR3TGFB1G6PDUGT1A61TXNRD1TGFB2ABCC3UGT1A9GSTP11CES5APTGR1GSTA5UGT1A11PRDX6HSP90AA1GGT1GSTA4NQO113DNAJB1CES1CES4ATGFAGSTT2UGT2B71SLC2A10SLC2A12GSTA2GCLMABCC5MAFFNRG1SLC2A5MGST2SERPINA1SQSTM1EGR1CES2SLC2A4SLC2A2UGT1A31SLC2A6SLC2A8FTLEPHA2HMOX1MAFGHBEGFHSPA1AKEAP1FTH1TGFBR2SLC2A3PDGFBAGERTXNRD3CYP4A11GenesTATA boxRXRALigandARENRF2 targetgenesGSTM5GSTM1GSTM2GSTM3GSTM4SLC5A2SLC5A1SLC5A4SLC5A10SLC5A9SLC5A6SLC5A11SLC5A12SLC5A3SLC5A7SLC5A8SLC5A5SLC6A2SLC6A1SLC6A4SLC6A11SLC6A9SLC6A6SLC6A13SLC6A14SLC6A3SLC6A7SLC6A8SLC6A5SLC6A16SLC6A15SLC6A18SLC6A20SLC6A17SLC6A19SLC39A2SLC39A1SLC39A4SLC39A10SLC39A9SLC39A6SLC39A11SLC39A12SLC39A3SLC39A7SLC39A8SLC39A5SLC39A13SLC39A14NFE2L2KEAP1NFE2L2LigandNFE2L2


Description

NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
  2. Haarmann-Stemmann T, Bothe H, Abel J; ''Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways.''; Biochem Pharmacol, 2009 PubMed Europe PMC Scholia
  3. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
  4. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  5. Mandard S, Mueller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  6. Nilsson S, Gustafsson JA; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  7. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohe R; ''The GI-GPx gene is a target for Nrf2.''; Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  8. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  9. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  10. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC Scholia
  11. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  12. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  13. Mueller M, Banning A, Brigelius-Flohe R, Kipp A; ''Nrf2 target genes are induced under marginal selenium-deficiency.''; Genes Nutr, 2010 PubMed Europe PMC Scholia
  14. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  15. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  16. Hayes JD, McMahon M; ''NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.''; Trends Biochem Sci, 2009 PubMed Europe PMC Scholia
  17. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  18. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH; ''AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.''; Chem Res Toxicol, 2007 PubMed Europe PMC Scholia
  19. Krogsdam AM, Nielsen CA, Neve S, Holst D, Helledie T, Thomsen B, Bendixen C, Mandrup S, Kristiansen K; ''Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.''; Biochem J, 2002 PubMed Europe PMC Scholia
  20. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  21. Fijten RR, Jennen DG, van Delft JH; ''Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants.''; Curr Drug Metab, 2013 PubMed Europe PMC Scholia
  22. Weiss C, Faust D, Duerk H, Kolluri SK, Pelzer A, Schneider S, Dietrich C, Oesch F, Goettlicher M; ''TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.''; Oncogene, 2005 PubMed Europe PMC Scholia
  23. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  24. Le Vee M, Jouan E, Fardel O; ''Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.''; Toxicol In Vitro, 2010 PubMed Europe PMC Scholia
  25. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  26. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  27. Vezina CM, Walker NJ, Olson JR; ''Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.''; Environ Health Perspect, 2004 PubMed Europe PMC Scholia
  28. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  29. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  30. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  31. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  32. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  33. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  34. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  35. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.''; Proc Natl Acad Sci U S A, 2004 PubMed Europe PMC Scholia
  36. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  37. Koehle C, Bock KW; ''Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  38. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
  39. Gao H, Faelt S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
  40. Rodriguez-Sosa M, Elizondo G, Lopez-Duran RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed Europe PMC Scholia
  41. Lindsey S, Papoutsakis ET; ''The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization.''; Br J Haematol, 2011 PubMed Europe PMC Scholia
  42. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.''; Nucl Recept, 2005 PubMed Europe PMC Scholia
  43. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  44. Jeon MS, Esser C; ''The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family.''; J Immunol, 2000 PubMed Europe PMC Scholia
  45. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
  46. Rowlands JC, Gustafsson JA; ''Aryl hydrocarbon receptor-mediated signal transduction.''; Crit Rev Toxicol, 1997 PubMed Europe PMC Scholia
  47. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  48. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalova J, Vondracek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  49. Mandard S, Mueller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  50. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  51. Mimura J, Fujii-Kuriyama Y; ''Functional role of AhR in the expression of toxic effects by TCDD.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106658view21:18, 12 September 2019KhanspersModified description
105659view05:16, 10 August 2019KhanspersModified description
103057view11:25, 7 February 2019SusanOntology Term : 'nuclear factor, erythroid 2 like 2 signaling pathway' added !
103022view15:44, 31 January 2019L DupuisUpdated Ensembl ID SRXN1
94787view22:51, 5 October 2017AlexanderPicoConverted lines and compacted layout
87956view13:11, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
83041view04:37, 18 November 2015Mkutmonfixed issue with literature references
83017view13:33, 17 November 2015FehrhartUpdate of outdated identifier
79992view20:05, 29 April 2015ZariCorrected Ensembl ID for SRXN1
79616view10:18, 29 March 2015EgonwConverted the 'ligand' labels to DataNode's and gave them ChEBI IDs.
79604view06:12, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79559view13:27, 25 March 2015FehrhartReplace Ensembl Human with Ensembl datasource
79518view09:36, 24 March 2015Riannefijtenadded reference
79483view13:02, 23 March 2015Riannefijtenconnected more unconnected lines
79482view13:00, 23 March 2015Riannefijtenchanged target gene categories and connected unconnected lines
79475view12:31, 23 March 2015RiannefijtenModified description
78726view12:08, 20 January 2015Bart SmeetsModified title
78725view12:06, 20 January 2015Bart SmeetsModified title
78560view10:31, 7 January 2015MaintBotadded missing graphIds
78182view10:37, 10 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC3GeneProductENSG00000108846 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCC5GeneProductENSG00000114770 (Ensembl)
ADH7GeneProductENSG00000196344 (Ensembl)
AGERGeneProductENSG00000204305 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
BLVRBGeneProductENSG00000090013 (Ensembl)
CBR1GeneProductENSG00000159228 (Ensembl)
CBR3GeneProductENSG00000159231 (Ensembl)
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CES4AGeneProductENSG00000172824 (Ensembl)
CES5AGeneProductENSG00000159398 (Ensembl)
CYP2A6GeneProductENSG00000255974 (Ensembl)
CYP4A11GeneProductENSG00000187048 (Ensembl)
DNAJB1GeneProductENSG00000132002 (Ensembl)
EGR1GeneProductENSG00000120738 (Ensembl)
EPHA2GeneProductENSG00000142627 (Ensembl)
EPHA3GeneProductENSG00000044524 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FTH1GeneProductENSG00000167996 (Ensembl)
FTLGeneProductENSG00000087086 (Ensembl)
G6PDGeneProductENSG00000160211 (Ensembl)
GCLCGeneProductENSG00000001084 (Ensembl)
GCLMGeneProductENSG00000023909 (Ensembl)
GGT1GeneProductENSG00000100031 (Ensembl)
GPX2GeneProductENSG00000176153 (Ensembl)
GPX3GeneProductENSG00000211445 (Ensembl)
GSRGeneProductENSG00000104687 (Ensembl)
GSTA1GeneProductENSG00000243955 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
GSTA3GeneProductENSG00000174156 (Ensembl)
GSTA4GeneProductENSG00000170899 (Ensembl)
GSTA5GeneProductENSG00000182793 (Ensembl)
GSTM1GeneProductENSG00000134184 (Ensembl)
GSTM2GeneProductENSG00000213366 (Ensembl)
GSTM3GeneProductENSG00000134202 (Ensembl)
GSTM4GeneProductENSG00000168765 (Ensembl)
GSTM5GeneProductENSG00000134201 (Ensembl)
GSTP1GeneProductENSG00000084207 (Ensembl)
GSTT1GeneProductENSG00000277656 (Ensembl)
GSTT2GeneProductENSG00000099984 (Ensembl)
HBEGFGeneProductENSG00000113070 (Ensembl)
HGFGeneProductENSG00000019991 (Ensembl)
HMOX1GeneProductENSG00000100292 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
HSP90AB1GeneProductENSG00000096384 (Ensembl)
HSPA1AGeneProductENSG00000204389 (Ensembl)
KEAP1GeneProductENSG00000079999 (Ensembl)
LigandMetaboliteCHEBI:48705 (ChEBI)
MAFFGeneProductENSG00000185022 (Ensembl)
MAFGGeneProductENSG00000197063 (Ensembl)
ME1GeneProductENSG00000065833 (Ensembl)
MGST2GeneProductENSG00000085871 (Ensembl)
MGST3GeneProductENSG00000143198 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
PDGFBGeneProductENSG00000100311 (Ensembl)
PGDGeneProductENSG00000142657 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PRDX1GeneProductENSG00000117450 (Ensembl)
PRDX6GeneProductENSG00000117592 (Ensembl)
PTGR1GeneProductENSG00000106853 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
SERPINA1GeneProductENSG00000197249 (Ensembl)
SLC2A10GeneProductENSG00000197496 (Ensembl)
SLC2A11GeneProductENSG00000133460 (Ensembl)
SLC2A12GeneProductENSG00000146411 (Ensembl)
SLC2A13GeneProductENSG00000151229 (Ensembl)
SLC2A14GeneProductENSG00000173262 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC2A3GeneProductENSG00000059804 (Ensembl)
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC2A5GeneProductENSG00000142583 (Ensembl)
SLC2A6GeneProductENSG00000160326 (Ensembl)
SLC2A7GeneProductENSG00000197241 (Ensembl)
SLC2A8GeneProductENSG00000136856 (Ensembl)
SLC2A9GeneProductENSG00000109667 (Ensembl)
SLC39A10GeneProductENSG00000196950 (Ensembl)
SLC39A11GeneProductENSG00000133195 (Ensembl)
SLC39A12GeneProductENSG00000148482 (Ensembl)
SLC39A13GeneProductENSG00000165915 (Ensembl)
SLC39A14GeneProductENSG00000104635 (Ensembl)
SLC39A1GeneProductENSG00000143570 (Ensembl)
SLC39A2GeneProductENSG00000165794 (Ensembl)
SLC39A3GeneProductENSG00000141873 (Ensembl)
SLC39A4GeneProductENSG00000147804 (Ensembl)
SLC39A5GeneProductENSG00000139540 (Ensembl)
SLC39A6GeneProductENSG00000141424 (Ensembl)
SLC39A7GeneProductENSG00000112473 (Ensembl)
SLC39A8GeneProductENSG00000138821 (Ensembl)
SLC39A9GeneProductENSG00000029364 (Ensembl)
SLC5A10GeneProductENSG00000154025 (Ensembl)
SLC5A11GeneProductENSG00000158865 (Ensembl)
SLC5A12GeneProductENSG00000148942 (Ensembl)
SLC5A1GeneProductENSG00000100170 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A3GeneProductENSG00000198743 (Ensembl)
SLC5A4GeneProductENSG00000100191 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A6GeneProductENSG00000138074 (Ensembl)
SLC5A7GeneProductENSG00000115665 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC5A9GeneProductENSG00000117834 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
SLC6A13GeneProductENSG00000010379 (Ensembl)
SLC6A14GeneProductENSG00000268104 (Ensembl)
SLC6A15GeneProductENSG00000072041 (Ensembl)
SLC6A16GeneProductENSG00000063127 (Ensembl)
SLC6A17GeneProductENSG00000197106 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC6A2GeneProductENSG00000103546 (Ensembl)
SLC6A3GeneProductENSG00000142319 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SLC6A5GeneProductENSG00000165970 (Ensembl)
SLC6A6GeneProductENSG00000131389 (Ensembl)
SLC6A7GeneProductENSG00000011083 (Ensembl)
SLC6A8GeneProductENSG00000130821 (Ensembl)
SLC6A9GeneProductENSG00000196517 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SOD3GeneProductENSG00000109610 (Ensembl)
SQSTM1GeneProductENSG00000161011 (Ensembl)
SRXN1GeneProductENSG00000271303 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TXNGeneProductENSG00000136810 (Ensembl)
TXNRD1GeneProductENSG00000198431 (Ensembl)
TXNRD3GeneProductENSG00000197763 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)
UGT2B7GeneProductENSG00000171234 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2884"
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