Wnt signaling - Q neuroblast migration (Caenorhabditis elegans)

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1, 312, 7, 971, 81, 4, 5671, 7NucleusQL neuroblastQR neuroblastPosterior migrationLIN-17/FrizzledPRY-1MIG-5mab-5/HoxMIG-14/MOM-3PorcupineMAB-5/HoxMIG-1/FrizzledEGL-20/Wnt1Anterior migrationmab-5/HoxMAB-5/HoxPRY-12, 6, 9Signaling cellEGL-20/WntBAR-1/beta-CateninBAR-1/beta-CateninNucleus


Description

One of the functions of the Wnt-signaling pathway in the nematode Caenorhabditis elegans (C. elegans) is to control the proper anterior-posterior axis migration of descendants of the QL and QR neuroblasts. In wild type animals, Wnt signaling is activated in the QL neuroblast to induce expression of the Hox gene mab-5 resulting in the appropriate posterior migration of QL descendants. Any disruption in the Wnt signaling pathway leading to mab-5 expression results in erroneous anterior migration of QL neuroblast descendants.

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Bibliography

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  1. Harris J, Honigberg L, Robinson N, Kenyon C; ''Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position.''; Development, 1996 PubMed Europe PMC Scholia
  2. Oosterveen T, Coudreuse DY, Yang PT, Fraser E, Bergsma J, Dale TC, Korswagen HC; ''Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans.''; Dev Biol, 2007 PubMed Europe PMC Scholia
  3. Hedgecock EM, Culotti JG, Hall DH, Stern BD; ''Genetics of cell and axon migrations in Caenorhabditis elegans.''; Development, 1987 PubMed Europe PMC Scholia
  4. Kenyon C; ''A gene involved in the development of the posterior body region of C. elegans.''; Cell, 1986 PubMed Europe PMC Scholia
  5. Salser SJ, Kenyon C; ''Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration.''; Nature, 1992 PubMed Europe PMC Scholia
  6. Maloof JN, Whangbo J, Harris JM, Jongeward GD, Kenyon C; ''A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans.''; Development, 1999 PubMed Europe PMC Scholia
  7. Korswagen HC; ''Canonical and non-canonical Wnt signaling pathways in Caenorhabditis elegans: variations on a common signaling theme.''; Bioessays, 2002 PubMed Europe PMC Scholia
  8. Way JC, Run JQ, Wang AY; ''Regulation of anterior cell-specific mec-3 expression during asymmetric cell division in C. elegans.''; Dev Dyn, 1992 PubMed Europe PMC Scholia
  9. Korswagen HC, Coudreuse DY, Betist MC, van de Water S, Zivkovic D, Clevers HC; ''The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.''; Genes Dev, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118034view11:46, 23 May 2021EweitzModified title
87430view13:22, 22 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
87261view14:42, 20 July 2016MaintBotmissing graphids
79197view23:47, 9 March 2015CgroveFixed unconnected lines
79196view22:38, 9 March 2015CgroveModified description
79195view22:34, 9 March 2015CgroveAdded references
79194view22:32, 9 March 2015CgroveAdded mig-5
79193view22:27, 9 March 2015CgrovePeriodical save, work in progress
79192view22:15, 9 March 2015CgroveAdding references
79191view22:07, 9 March 2015CgrovePeriodical save, work in progress
78279view02:16, 20 December 2014CgrovePeriodical save, work in progress
78278view02:06, 20 December 2014CgrovePeriodical save, work in progress
78277view01:56, 20 December 2014CgrovePeriodical save, work in progress
78276view01:42, 20 December 2014CgroveSpecify description
78275view01:33, 20 December 2014CgrovePeriodical save, work in progress
78274view01:24, 20 December 2014CgroveSpecify description
78273view01:23, 20 December 2014CgrovePeriodical save, work in progress
78272view01:15, 20 December 2014CgroveSpecify description
78271view01:13, 20 December 2014CgrovePeriodical save, work in progress
78270view01:11, 20 December 2014Cgroveudpate
78269view01:08, 20 December 2014CgroveNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
BAR-1/ beta-CateninGeneProductC54D1.6 (WormBase)
EGL-20/WntProteinW08D2.1 (WormBase)
LIN-17/FrizzledGeneProductY71F9B.5 (WormBase)
MAB-5/HoxGeneProductC08C3.3 (WormBase)
MIG-1/FrizzledGeneProductY34D9B.1 (WormBase)
MIG-14/MOM-3 PorcupineGeneProductR06B9.6 (WormBase)
MIG-5GeneProductWBGene00003241 (WormBase)
PRY-1GeneProductC37A5.9 (WormBase)
mab-5/HoxGeneProductC08C3.3 (WormBase)

Annotated Interactions

No annotated interactions

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