Growth hormone (GH) signaling (Bos taurus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusIGF1-IGF1R AxisGrowthGHRJAK2JAK2IGFBP-3IGF-1IGF-1STAT5bGH1STAT5bSTAT5bName: Growth hormone (GH) signalingOrganism: Bos taurus


Description

The growth Hormone/Insulin-Like Growth Factor axis is a complex system of ligands, binding protein and receptors which the cells use for communication of growth simulating signal. GH is released from the pituitary and by binding to the GH receptor it stimulates longitudinal growth and has anabolic effects on metabolism. Most of the growth-promoting effects of GH are mediated by IGF-1 which is produced mainly in the liver after GH stimulation. IGF-1 has crucial functions especially for embryonic growth and development. This pathway is primarily studied to understand factors that contribute to growth in bos taurus(Jiang et al.)

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Quality Tags

Ontology Terms

Pathway Ontology : RNA degradation pathway
 

Bibliography

  1. Jiang H, Ge X; ''MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--mechanism of growth hormone stimulation of skeletal muscle growth in cattle.''; J Anim Sci, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117529view11:10, 21 May 2021EweitzModified title
78846view15:42, 5 February 2015Mkutmonsmall layout change
78844view15:25, 5 February 2015Mkutmonremoved empty literature reference
78843view15:23, 5 February 2015Mkutmonupdated layout and connected lines
78830view19:00, 3 February 2015ZariModified description
78829view18:59, 3 February 2015ZariModified description
78828view12:38, 3 February 2015ZariModified description
78827view11:46, 3 February 2015ZariModified description
78826view11:42, 3 February 2015ZariOntology Term : 'growth factor signaling pathway' added !
78825view11:38, 3 February 2015ZariNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
GH1GeneProduct280804 (Entrez Gene)
GHRGeneProduct280805 (Entrez Gene)
IGF-1GeneProduct281239 (Entrez Gene)
IGFBP-3GeneProduct282261 (Entrez Gene)
JAK2GeneProduct525246 (Entrez Gene)
STAT5bGeneProduct282376 (Entrez Gene)

Annotated Interactions

No annotated interactions

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