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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell cycle arrest Apoptosis Inhibition of angiogenesis and metastasis DNA repair and damage prevention Inhibition of IGF-1/mTOR pathway Exosome mediated secretion p53 negative feedback G1 arrest (sustained) G2 arrest (sustained) DNA damage Genotoxic stress Endpoint Target genes Stress signals Atm Chek2 Atr Chek1 Cdkn2a Mdm2 Mdm4 Trp53 Cdkn1a Sfn Rprm Gtse1 Fas Pidd1 Casp8 Bid Bax Pmaip1 Bbc3 Ei24 Shisa5 Perp Zmat3 Apaf1 Casp9 Casp3 Igfbp3 Igf1 Serpine1 Bai1 Cd82 Thbs1 Serpinb5 Ddb2 Pten Tsc2 Steap3 Rfwd2 Rchy1 Ppm1d Trp73 mmu-miR-29b-3p mmu-miR-103a-3p Gadd45a Gadd45b Gadd45g Ccnd1 Ccnd2 Ccnd3 Cdk4 Cdk6 Ccne1 Ccne2 Cdk2 Ccnb1 Ccnb2 Ccnb3 Gm5593 Cdk1 Siah1a Siah1b Cycs Cyct Rrm2b Rrm2 Sesn1 Sesn2 Sesn3 Ccng1 Ccng2 mmu-miR-291a-3p mmu-miR-291b-3p mmu-miR-294-3p mmu-miR-295-3p mmu-miR-302d-3p mmu-miR-18a-5p mmu-miR-20a-5p mmu-miR-216a-5p mmu-miR-217-5p mmu-miR-486-5p mmu-miR-21-5p mmu-miR-19b-3p mmu-miR-17-5p mmu-miR-21a-5p mmu-miR-145a-5p mmu-miR-124-3p mmu-miR-503-5p mmu-miR-503-5p mmu-miR-181b-5p mmu-miR-34b-5p mmu-miR-340-5p mmu-miR-19b-3p mmu-miR-149-5p mmu-miR-16-5p mmu-miR-15a-5p mmu-miR-1a-3p mmu-miR-362-5p mmu-miR-362-5p mmu-miR-30e-5p mmu-miR-16-5p mmu-miR-122-5p mmu-miR-195a-5p mmu-miR-758-3p mmu-miR-449a-5p mmu-let-7b-5p mmu-miR-15a-5p mmu-miR-425-5p mmu-miR-223-3p mmu-miR-7b-5p mmu-miR-24-3p mmu-miR-301b-3p mmu-miR-9-5p mmu-miR-181a-5p mmu-miR-297a-5p mmu-miR-17-5p mmu-miR-149-5p mmu-miR-362-5p mmu-miR-24-3p Gadd45g Gadd45b Gadd45a Igfbp3 Mdm2 Siah1a Siah1b mmu-miR-425-5p mmu-miR-301b-3p mmu-miR-301b-3p mmu-miR-19b-3p mmu-miR-301b-3p mmu-miR-19b-3p mmu-miR-19b-3p mmu-miR-340-5p mmu-miR-34b-5p mmu-miR-15a-5p mmu-let-7b-5p mmu-miR-15a-5p Name: p53 signaling Organism: Mus musculus
Description
http://www.kegg.jp/ (mmu04115)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
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Quality Tags
Approved version The current version of this pathway was approved for data analysis by Martina Kutmon .
Ontology Terms
Bibliography
Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC; ''Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.''; Mutagenesis, 2015 PubMed Europe PMC Scholia History
External references
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