Monoamine transport (Bos taurus)

From WikiPathways

Jump to: navigation, search
127, 202412830288122716122341230224, 306, 22302816191223, 30112312692426271216, 187431, 16, 29102819517, 2127102, 151381725202811272514121928Synthesis Cell MembraneNegative RegulationSmall MoleculeProtein ModificationExpressionProteinTransportNegative ExpressionGolgiNegative TransportNucleusBindingRegulationLEGENDRBL2TSC2HEPESSTX1ASYN1AMPHSCAMP2reserpinenoradrenalineanisomycinPVRL2TNFSLC5A7FBXO32SLC6A2INTB3SB 203580CDC25CNOS1ACHEdopamineepinephrineDBHTDO24-Aminobutanoic acidTNFRSF11BcatecholaminesAGTSLC6A3serotoninTPH2Hemicholinium-3HRH3MAPK14TGFB1I1Phorbol esterSLC6A1IL1R1citalopramUNC13BL-tryptophanADORA2ATHPPP2CBIL1BSLC6A4


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP727(79969) with a 100.0% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR; ''Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  2. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N; ''Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.''; Neuroscience, 2008 PubMed Europe PMC Scholia
  3. Hahn MK, Blakely RD; ''The functional impact of SLC6 transporter genetic variation.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  4. Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S; ''Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  5. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T; ''''; , PubMed Europe PMC Scholia
  6. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD; ''Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  7. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  8. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD; ''A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  9. Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI; ''Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia
  10. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  11. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  12. Zhu CB, Blakely RD, Hewlett WA; ''The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.''; Neuropsychopharmacology, 2006 PubMed Europe PMC Scholia
  13. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  14. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  15. Hahn MK, Blakely RD; ''Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia
  16. Miner LH, Schroeter S, Blakely RD, Sesack SR; ''Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals.''; J Comp Neurol, 2003 PubMed Europe PMC Scholia
  17. Savchenko V, Sung U, Blakely RD; ''Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody.''; Mol Cell Neurosci, 2003 PubMed Europe PMC Scholia
  18. Hahn MK, Robertson D, Blakely RD; ''A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  19. Iwamoto H, Blakely RD, De Felice LJ; ''Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  20. Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A; ''Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  21. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  22. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD; ''Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  23. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD; ''p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  24. Sung U, Blakely RD; ''Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A.''; Mol Cell Neurosci, 2007 PubMed Europe PMC Scholia
  25. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  26. Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD; ''Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  27. Dipace C, Sung U, Binda F, Blakely RD, Galli A; ''Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
  28. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  29. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  30. Steiner JA, Carneiro AM, Blakely RD; ''Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.''; Traffic, 2008 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
134259view05:04, 18 July 2024EgonwRemoved template comments
117553view11:18, 21 May 2021EweitzModified title
107058view14:14, 17 September 2019MaintBotChEBI identifier normalization
80663view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-Aminobutanoic acidMetabolite56-12-2 (CAS)
ACHEGeneProductENSBTAG00000001139 (Ensembl)
  • acetylcholinesterase (Yt blood group)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:43
ADORA2AGeneProductENSBTAG00000016944 (Ensembl)
  • adenosine A2a receptor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:135
AGTGeneProductENSBTAG00000012393 (Ensembl)
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:183
AMPHGeneProductENSBTAG00000031967 (Ensembl)
  • amphiphysin
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:273
CDC25CGeneProductENSBTAG00000005293 (Ensembl)
  • cell division cycle 25 homolog C (S. pombe)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:995
DBHGeneProductENSBTAG00000004508 (Ensembl)
  • dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1621
FBXO32GeneProductENSBTAG00000016194 (Ensembl)
  • F-box protein 32
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114907
HEPESMetabolite7365-45-9 (CAS)
HRH3GeneProductENSBTAG00000031625 (Ensembl)
  • histamine receptor H3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11255
Hemicholinium-3Metabolite312-45-8 (CAS)
IL1BGeneProductENSBTAG00000001321 (Ensembl)
  • interleukin 1 beta
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1GeneProductENSBTAG00000005273 (Ensembl)
  • interleukin 1 receptor, type I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
INTB3GeneProductENSBTAG00000009987 (Ensembl)
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
L-tryptophanMetabolite73-22-3 (CAS)
MAPK14GeneProductENSBTAG00000020783 (Ensembl)
  • mitogen activated protein kinase 14
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
NOS1GeneProductENSBTAG00000002023 (Ensembl)
  • nitric oxide synthase 1 (neuronal)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
PPP2CBGeneProductENSBTAG00000009245 (Ensembl)
  • protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5516
PVRL2GeneProductENSBTAG00000015318 (Ensembl)
  • poliovirus receptor-related 2 (herpesvirus entry mediator B)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5819
Phorbol esterMetabolite16561-29-8 (CAS)
RBL2GeneProductENSBTAG00000016243 (Ensembl)
  • retinoblastoma-like 2 (p130)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5934
SB 203580Metabolite152121-47-6 (CAS)
SCAMP2GeneProductENSBTAG00000005844 (Ensembl)
  • secretory carrier membrane protein 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10066
SLC5A7GeneProductENSBTAG00000004352 (Ensembl)
  • solute carrier family 5 (choline transporter), member 7
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60482
SLC6A1GeneProductENSBTAG00000005857 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6529
SLC6A2GeneProductENSBTAG00000003353 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6530
SLC6A3GeneProductENSBTAG00000015843 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6531
SLC6A4GeneProductENSBTAG00000019349 (Ensembl)
  • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6532
STX1AGeneProductENSBTAG00000017075 (Ensembl)
  • syntaxin 1A (brain)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6804
SYN1GeneProductENSBTAG00000005042 (Ensembl)
  • synapsin I
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6853
TDO2GeneProductENSBTAG00000011062 (Ensembl)
  • tryptophan 2,3-dioxygenase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6999
TGFB1I1GeneProductENSBTAG00000002391 (Ensembl)
  • transforming growth factor beta 1 induced transcript 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7041
THGeneProductENSBTAG00000026768 (Ensembl)
  • tyrosine hydroxylase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7054
TNFGeneProductENSBTAG00000025471 (Ensembl)
  • tumor necrosis factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
TNFRSF11BGeneProductENSBTAG00000007423 (Ensembl)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4982
TPH2GeneProductENSBTAG00000020792 (Ensembl)
  • tryptophan hydroxylase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:121278
TSC2GeneProductENSBTAG00000020617 (Ensembl)
  • tuberous sclerosis 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249
UNC13BGeneProductENSBTAG00000011397 (Ensembl)
  • unc-13 homolog B (C. elegans)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10497
anisomycinMetaboliteCHEBI:338412 (ChEBI)
catecholaminesMetaboliteCHEBI:33567 (ChEBI)
citalopramMetabolite59729-33-8 (CAS)
dopamineMetabolite51-61-6 (CAS)
epinephrineMetabolite51-43-4 (CAS)
noradrenalineMetabolite51-41-2 (CAS)
reserpineMetabolite50-55-5 (CAS)
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
Personal tools