Trans-sulfuration pathway (Bos taurus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Tetrahydrofolate (THF)L-Methionine5-Methyl-THFL-HomocysteineS-Adenosylmethionine (SAMe)S-Adenosylhomocysteine (SAH)L-CysteineGlutathioneTaurineL-GlutamatePyruvateMTRATPMAT2BDNA, proteins, metabolitesMethylated productsDNMT1AHCYGCLMCSADADPCBSCTHCTHGOT1MPSTGCLMPhosphateName: Trans-sulfuration pathwayLast Modified: 10/16/2013Organism: Bos taurus


Description

Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2333(72015) with a 100.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

Bibliography

  1. Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
80707
Approved
view15:22, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
5-Methyl-THFMetaboliteC00440 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
AHCYGeneProductENSBTAG00000018101 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:191
ATPMetaboliteC00002 (KEGG Compound)
CBSGeneProductENSBTAG00000000160 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:875
CSADGeneProductENSBTAG00000007829 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51380
CTHGeneProductENSBTAG00000014791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1491
DNA, proteins, metabolites
DNMT1GeneProductENSBTAG00000002736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786
GCLMGeneProductENSBTAG00000007842 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
GOT1GeneProductENSBTAG00000011960 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805
GlutathioneMetaboliteC00051 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
L-HomocysteineMetaboliteC00155 (KEGG Compound)
L-MethionineMetaboliteC00073 (KEGG Compound)
MAT2BGeneProductENSBTAG00000012350 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27430
MPSTGeneProductENSBTAG00000030648 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4357
MTRGeneProductENSBTAG00000012251 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4548
Methylated products
PhosphateMetaboliteC00009 (KEGG Compound)
PyruvateMetaboliteC00022 (KEGG Compound)
S-Adenosylhomocysteine (SAH)MetaboliteC00021 (KEGG Compound)
S-Adenosylmethionine (SAMe)MetaboliteC00019 (KEGG Compound)
TaurineMetaboliteC00245 (KEGG Compound)
Tetrahydrofolate (THF)MetaboliteC00101 (KEGG Compound)

Annotated Interactions

No annotated interactions
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