Pathogenic Escherichia coli infection (Bos taurus)

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ToxinsROCK2ARHGEF2E-CADHERINHCLS1OCLNTUBA1CITGB1TUBB6PRKCAACTBStxBTUBB1ARPC2NCK2StxAYWHAQTUBB2BTirEZRApoptosisTUBB3TirTUBA1BEspG2CD14PhosphatidylethanolamineTUBA3DTUBA4ATUBB4QKRT18Tight junctionEspFactin-related protein 2/3 complex subunit 1B-likeEspFACTG1EspHTUBA3EARPC3Adherens junctionOCLNCTNNB1TLR5TUBB4BMD2ARPC1AEspHTUBAL3ARPC1BFYNTUBB8WASLTUBB5ARPC5LTUBB2BEspGTUBA3CEspG2Regulation of actin cytoskeletonCDC42ARPC5EspFUCLDN1YWHAZFlagellar assemblyCTTNEaeTUBB4ANCLEspFUEspGEspFUWASTLR4MapRHOARegulation of actin cytoskeletonTUBA8NCK1ABL1Toll-like receptor signaling pathwayBfpTUBA1AROCK1MapARPC4Pathogen: Enteropathogenic escherichia coli (EPEC)Enterohermorrhagic escherichia coli (EHEC)PilusLEE-encoded effectorsnon-LEE-encoded effectorsProphage-carried effectorsType III proteinsecretion systemFlagellinLPSHost: Small intestinal epithelial cell (EPEC)Large intestinal epithelial cell (EHEC)NleHNleAInflammationStress fiber formationPedestal formationCytoskeletonrearrangementDisruption ofmicrotuble networkRetraction of filopodiumFilipodium formationAlterations in theIF network architectureDisruption of tight junctionsDisruption of adherens junctionsDisruption of barrierfunction and increase inmonolayer permeabilityRedistributionMitochondrial dysfunctionouter membrane proteinp+p+TranslocationIntestinal tractKidney .......Inhibition of protein synthesisTUBB6TUBB1TUBB4QTUBB8TUBB2BTUBB4ATUBB4BTUBB5TUBB2BTUBB3


Description

Sources: KEGG

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2272(78594) with a 61.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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History

CompareRevisionActionTimeUserComment
80723view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProductENSBTAG00000017976 (Ensembl)
  • Original kegg element: gene;35;hsa:25 hsa:2534
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
ACTBGeneProductENSBTAG00000026199 (Ensembl)
  • Original kegg element: gene;55;hsa:60 hsa:71
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:60
ACTG1GeneProductENSBTAG00000006189 (Ensembl)
  • Original kegg element: gene;55;hsa:60 hsa:71
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:71
ARHGEF2GeneProductENSBTAG00000000113 (Ensembl)
  • Original kegg element: gene;42;hsa:9181
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9181
ARPC1AGeneProductENSBTAG00000004242 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10552
ARPC1BGeneProductENSBTAG00000046248 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10095
ARPC2GeneProductENSBTAG00000010386 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10109
ARPC3GeneProductENSBTAG00000005345 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10094
ARPC4GeneProductENSBTAG00000007964 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10093
ARPC5GeneProductENSBTAG00000045582 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10092
ARPC5LGeneProductENSBTAG00000015278 (Ensembl)
  • Original kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81873
Adherens junctionGeneProductOriginal kegg element: map;5;path:hsa04520
ApoptosisGeneProductOriginal kegg element: map;19;path:hsa04210
BfpGeneProduct
CD14GeneProductENSBTAG00000015032 (Ensembl)
  • Original kegg element: gene;2;hsa:929
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:929
CDC42GeneProductENSBTAG00000001700 (Ensembl)
  • Original kegg element: gene;32;hsa:998
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
CLDN1GeneProductENSBTAG00000013148 (Ensembl)
  • Original kegg element: gene;39;hsa:9076
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9076
CTNNB1GeneProductENSBTAG00000016420 (Ensembl)
  • Original kegg element: gene;26;hsa:1499
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
CTTNGeneProductENSBTAG00000006071 (Ensembl)
  • Original kegg element: gene;27;hsa:2017 hsa:3059
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2017
E-CADHERINGeneProductENSBTAG00000015991 (Ensembl)
  • Original kegg element: gene;17;hsa:999
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:999
EZRGeneProductENSBTAG00000010347 (Ensembl)
  • Original kegg element: gene;31;hsa:7430
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7430
EaeGeneProduct
EspFGeneProduct
EspFUGeneProduct
EspGGeneProduct
EspG2GeneProduct
EspHGeneProduct
FYNGeneProductENSBTAG00000011851 (Ensembl)
  • Original kegg element: gene;35;hsa:25 hsa:2534
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
Flagellar assemblyGeneProductOriginal kegg element: map;4;path:map02040
HCLS1GeneProductENSBTAG00000001009 (Ensembl)
  • Original kegg element: gene;27;hsa:2017 hsa:3059
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3059
ITGB1GeneProductENSBTAG00000015910 (Ensembl)
  • Original kegg element: gene;40;hsa:3688
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
KRT18GeneProductENSBTAG00000001517 (Ensembl)
  • Original kegg element: gene;25;hsa:3875
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3875
MD2GeneProductENSBTAG00000008864 (Ensembl)
  • Original kegg element: gene;3;hsa:23643
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23643
MapGeneProduct
NCK1GeneProductENSBTAG00000018427 (Ensembl)
  • Original kegg element: gene;41;hsa:4690 hsa:8440
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
NCK2GeneProductENSBTAG00000015205 (Ensembl)
  • Original kegg element: gene;41;hsa:4690 hsa:8440
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8440
NCLGeneProductENSBTAG00000016174 (Ensembl)
  • Original kegg element: gene;45;hsa:4691
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4691
NleAGeneProduct
NleHGeneProduct
OCLNGeneProductOriginal kegg element: gene;30;hsa:100506658 hsa:4950
OCLNGeneProductENSBTAG00000000561 (Ensembl)
  • Original kegg element: gene;30;hsa:100506658 hsa:4950
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:100506658
PRKCAGeneProductENSBTAG00000001061 (Ensembl)
  • Original kegg element: gene;36;hsa:5578
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
RHOAGeneProductENSBTAG00000004279 (Ensembl)
  • Original kegg element: gene;44;hsa:387
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:387
ROCK1GeneProductENSBTAG00000008403 (Ensembl)
  • Original kegg element: gene;28;hsa:6093 hsa:9475
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ROCK2GeneProductENSBTAG00000005847 (Ensembl)
  • Original kegg element: gene;28;hsa:6093 hsa:9475
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
Regulation of actin cytoskeletonGeneProductOriginal kegg element: map;20;path:hsa04810
StxAGeneProduct
StxBGeneProduct
TLR4GeneProductENSBTAG00000006240 (Ensembl)
  • Original kegg element: gene;9;hsa:7099
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7099
TLR5GeneProductENSBTAG00000000477 (Ensembl)
  • Original kegg element: gene;10;hsa:7100
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7100
TUBA1AGeneProductENSBTAG00000001489 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7846
TUBA1BGeneProductENSBTAG00000012244 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10376
TUBA1CGeneProductENSBTAG00000039992 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84790
TUBA3CGeneProduct
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000030979;En:ENSBTAG00000030979;
TUBA3DGeneProduct
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Multiple homologues found: En:ENSBTAG00000030979;En:ENSBTAG00000030979;
TUBA3EGeneProductENSBTAG00000030979 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:112714
TUBA4AGeneProductENSBTAG00000030974 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7277
TUBA8GeneProductENSBTAG00000018530 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51807
TUBAL3GeneProductENSBTAG00000017740 (Ensembl)
  • Original kegg element: gene;15;hsa:10376 hsa:112714 hsa:113457 hsa:51807 hsa:7277 hsa:7278 hsa:7846 hsa:79861 hsa:84790
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79861
TUBB1GeneProductENSBTAG00000018785 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81027
TUBB2BGeneProductENSBTAG00000004093 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:347733
TUBB2BGeneProductENSBTAG00000046886 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7280
TUBB3GeneProductENSBTAG00000023730 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10381
TUBB4AGeneProductENSBTAG00000021013 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10382
TUBB4BGeneProductENSBTAG00000025274 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10383
TUBB4QGeneProductOriginal kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
TUBB5GeneProductENSBTAG00000006969 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:203068
TUBB6GeneProductENSBTAG00000046337 (Ensembl)
  • Original kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84617
TUBB8GeneProductOriginal kegg element: gene;47;hsa:10381 hsa:10382 hsa:10383 hsa:203068 hsa:347688 hsa:347733 hsa:56604 hsa:7280 hsa:81027 hsa:84617
Tight junctionGeneProductOriginal kegg element: map;6;path:hsa04530
TirGeneProduct
Toll-like receptor signaling pathwayGeneProductOriginal kegg element: map;7;path:hsa04620
Type III protein secretion systemGeneProductOriginal kegg element: map;4;path:map02040
WASGeneProductENSBTAG00000046555 (Ensembl)
  • Original kegg element: gene;37;hsa:7454 hsa:8976
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7454
WASLGeneProductENSBTAG00000004643 (Ensembl)
  • Original kegg element: gene;37;hsa:7454 hsa:8976
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8976
YWHAQGeneProductENSBTAG00000002108 (Ensembl)
  • Original kegg element: gene;18;hsa:10971
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10971
YWHAZGeneProductENSBTAG00000000236 (Ensembl)
  • Original kegg element: gene;23;hsa:7534
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7534
actin-related protein 2/3 complex subunit 1B-likeGeneProductOriginal kegg element: gene;54;hsa:10092 hsa:10093 hsa:10094 hsa:10095 hsa:10109 hsa:10552 hsa:653888 hsa:81873

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3157"
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