Colchicine metabolic pathway (Bos taurus)

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Approved version The current version of this pathway was approved for data analysis by Martina Kutmon.

Homology Converted Comment: Inferred from another species Revision {{{tag_revision}}} of this pathway has been inferred from another species (tagged by Maintenance bot). Expression error: Unrecognised punctuation character "{"

Ontology Terms

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Bibliography

1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC Scholia
2. Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
2DMC	Metabolite	22210 (Chemspider)
3DMC	Metabolite	264748 (Chemspider)
CYP3A4	Protein	ENSBTAG00000047379 (Ensembl)	HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P08684
Colchicine	Metabolite	5933 (Chemspider)

Annotated Interactions