Human genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regulated (P < 0.05) hSkM genes identified in the diurnal comparison (0800 h and 2000 h) were subjected to an additional statistical filter of absolute fold change > 20% (n = 239) and linked to mouse circadianly regulated orthologues. This pathway represents the resultant 44 putative hSkM circadianly regulated genes; L, promoter for the light-responsive element; E, E-box (Clock/Bmal1 promoter). Orthologue information is denoted to the left of the gene boxes: mHrts and mLvrs, mouse orthologue was circadianly regulated as described (Storch 2002) in mouse heart or liver, respectively; mLvrp and mSCNp, mouse orthologue was diurnally regulated as described (Panda 2002) in mouse liver or SCN, respectively.
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GenMAPP notes
Time- and exercise-dependent gene regulation in human skeletal muscle
Alexander C Zambon, Erin L McDearmon, Nathan Salomonis, Karen M Vranizan, Kirsten L Johansen, Deborah Adey, Joseph S Takahashi, Morris Schambelan, Bruce R Conklin
Genome Biology 4(10): R61 http://genomebiology.com/2003/4/10/R61
Published 25 September 2003
HomologyConvert
This pathway was inferred from Homo sapiens pathway WP410(69903) with a 97.0% conversion rate.
Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB; ''Coordinated transcription of key pathways in the mouse by the circadian clock.''; Cell, 2002 PubMedEurope PMCScholia
Storch KF, Lipan O, Leykin I, Viswanathan N, Davis FC, Wong WH, Weitz CJ; ''Extensive and divergent circadian gene expression in liver and heart.''; Nature, 2002 PubMedEurope PMCScholia
Alexander C Zambon, Erin L McDearmon, Nathan Salomonis, Karen M Vranizan, Kirsten L Johansen, Deborah Adey, Joseph S Takahashi, Morris Schambelan, Bruce R Conklin
Genome Biology 4(10): R61
http://genomebiology.com/2003/4/10/R61
Published 25 September 2003
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