Heart development (Bos taurus)

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4877361156536LVASRACardiac Neural CrestFibroblastCTRVSecond Heart FieldFirst Heart FieldDay 28LACardiac Reprogramming FactorsBMPRIIHEY2ERBB3FOXA2GATA4TBX5SRFNKX2-5VEGFATBX1TBX2FGF10NOTCH1TBX5bta-mir-1-1ISL1NFATC3FOXC2HAND1NOTCH1TBX5GATA6VEGFCNFATC4NKX2-5PITX2GATA4BHLHE40BMP2MEF2CBMP10BMP2FGF8PTPN11BMP4bta-mir-143IRX4TBX20VEGFBSRFNKX2-5HAND2NKX2-5SMYD1FOXC1TBX20BMPR-IASMAD1NKX2-5MIR145SMAD4MAPK1NFATC2MEF2CGATA4CTNNB1FOXH1HEY1MEF2CSHHNFATC1TBX2TBX5GATA4Sternal GenesCombination of First and SecondHeart Fields (Heart Valves)


Description

This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1591(78590) with a 93.0% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Fulcoli FG, Huynh T, Scambler PJ, Baldini A; ''Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner.''; PLoS One, 2009 PubMed Europe PMC Scholia
  2. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D; ''Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.''; Cell, 2010 PubMed Europe PMC Scholia
  3. Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT; ''Development of heart valves requires Gata4 expression in endothelial-derived cells.''; Development, 2006 PubMed Europe PMC Scholia
  4. Srivastava D; ''Making or breaking the heart: from lineage determination to morphogenesis.''; Cell, 2006 PubMed Europe PMC Scholia
  5. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP; ''An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.''; Cell, 2007 PubMed Europe PMC Scholia
  6. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D; ''A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate.''; Nat Cell Biol, 2009 PubMed Europe PMC Scholia
  7. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D; ''miR-145 and miR-143 regulate smooth muscle cell fate and plasticity.''; Nature, 2009 PubMed Europe PMC Scholia
  8. Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O; ''BMP and BMP receptor expression during murine organogenesis.''; Gene Expr Patterns, 2009 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
117534view11:14, 21 May 2021EweitzModified title
88635view14:46, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
80935view15:31, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BHLHE40GeneProductENSBTAG00000009863 (Ensembl)
  • In other species, this is BHLHB2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8553
BMP10GeneProductENSBTAG00000000992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27302
BMP2GeneProductENSBTAG00000005111 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
BMP4GeneProductENSBTAG00000003835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
BMPR-IAGeneProductENSBTAG00000000231 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:657
BMPRIIGeneProductENSBTAG00000006420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:659
CTNNB1GeneProductENSBTAG00000016420 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
ERBB3GeneProductENSBTAG00000010444 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2065
FGF10GeneProduct
FGF8GeneProductENSBTAG00000001530 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2253
FOXA2GeneProductENSBTAG00000012407 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3170
FOXC1GeneProduct
FOXC2GeneProductENSBTAG00000012465 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2303
FOXH1GeneProductENSBTAG00000004761 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
GATA4GeneProductENSBTAG00000005425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
GATA6GeneProductENSBTAG00000005734 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2627
HAND1GeneProductENSBTAG00000002335 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9421
HAND2GeneProductENSBTAG00000044123 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9464
HEY1GeneProductENSBTAG00000015717 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23462
HEY2GeneProductENSBTAG00000000919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23493
IRX4GeneProductENSBTAG00000015907 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50805
ISL1GeneProductENSBTAG00000001241 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3670
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MEF2CGeneProductENSBTAG00000020701 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
MIR145GeneProduct
NFATC1GeneProductENSBTAG00000000656 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4772
NFATC2GeneProductENSBTAG00000018270 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4773
NFATC3GeneProductENSBTAG00000004368 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4775
NFATC4GeneProductENSBTAG00000006366 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4776
NKX2-5GeneProductENSBTAG00000020568 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
NOTCH1GeneProductENSBTAG00000022799 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851
PITX2GeneProductENSBTAG00000009059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5308
PTPN11GeneProductENSBTAG00000002048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
SHHGeneProductENSBTAG00000024552 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6469
SMAD1GeneProductENSBTAG00000002835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086
SMAD4GeneProductENSBTAG00000006919 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMYD1GeneProductENSBTAG00000021120 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:150572
SRFGeneProductENSBTAG00000012777 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
TBX1GeneProduct
TBX20GeneProductENSBTAG00000017541 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57057
TBX2GeneProductENSBTAG00000014278 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6909
TBX5GeneProductENSBTAG00000011384 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6910
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
VEGFBGeneProductENSBTAG00000047567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7423
VEGFCGeneProductENSBTAG00000014737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7424
bta-mir-1-1GeneProductENSBTAG00000029790 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199017
bta-mir-143GeneProductENSBTAG00000030114 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208035

Annotated Interactions

No annotated interactions
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