MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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1, 2Ovarian Cancer CellTroponin C interacts with F-actinCalcium selective/non-selectivecation channelIncrease cell motilityIncrease traction forceExtracellular calcium sourceActivated JUN forms transcription complex with cofactorTranscription of Troponin CCofactorMFAP5Ca2+FAKTroponin CPRKCQITGB3DAGPLCG1CREB1PIP2RYR3TNNC1ITPR3IP3JUNERK2ITGAVPPCancer-associated stromal fibroblasts(CAFs)Ca2+Ca2+Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationFAKPPRKCQPPLCG1PTroponin CCofactorCREB1PTranscription of JunCREB1ERK2Ca2+Ca2+JUNERK1ERK1PP


Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in Leung et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Ontology Terms

 

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127230view20:08, 25 August 2023Khanspersadded lit ref and updated description
127188view22:11, 9 August 2023Khanspersupdated phosphosites
126996view19:27, 14 July 2023Khanspersclarify interactions, updated labels, some reactions
120029view23:19, 15 October 2021Khanspersupdated phosphosites
108104view10:16, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteHMDB0007098 (HMDB)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
TNNC1GeneProductENSG00000114854 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

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