MicroRNA for targeting cancer growth and vascularization in glioblastoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Notch intracellular domainTumor growthStem cell maintenanceAbnormal angiogenesisHIF1ANHES1HEY1MIR31MIR148AVEGFAVEGFBVEGFCHIF1AHIF1ANICDName: MicroRNA for targeting cancer growth and vascularization in glioblastomaOrganism: Homo sapiens


Description

miR-148a and miR-31 target the factor inhibiting hypoxia (FIH1) to promote downstream HIF1α and Notch signaling

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Quality Tags

Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Wong HK, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM; ''The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma.''; Mol Ther, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137382
Approved
view22:58, 1 March 2025EweitzClear dimension cache
137381view22:57, 1 March 2025EweitzEconomize layout
129317
CPTAC
view13:54, 26 March 2024MkutmonOntology Term : 'cancer pathway' added !
129316view13:54, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
128547view22:36, 11 February 2024EweitzEconomize layout, standardize case
117786view14:03, 22 May 2021EweitzOntology Term : 'microRNA pathway' added !
117785view14:03, 22 May 2021EweitzOntology Term : 'PW:0000013' removed !
117784view14:03, 22 May 2021EweitzOntology Term : 'PW:0000605' removed !
117783view14:02, 22 May 2021EweitzOntology Term : 'glioblastoma' added !
117782view14:02, 22 May 2021EweitzOntology Term : 'DOID:162' removed !
117781view14:02, 22 May 2021EweitzModified title
108122view10:24, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
97691view01:01, 2 June 2018AlexanderPicoModified title
94282view19:07, 30 August 2017Khanspersupdated for clarity
87762view09:58, 25 July 2016RyanmillerOntology Term : 'glioma pathway' added !
87735view09:42, 25 July 2016RyanmillerOntology Term : 'cancer' added !
87705view09:03, 25 July 2016RyanmillerOntology Term : 'disease pathway' added !
84853view21:49, 28 March 2016Khanspersupdated interactions and refined NICD/HIF1a
84088view05:21, 14 January 2016Khanspersincreased text label size to avoid cutoff text
83871view00:54, 18 December 2015KhanspersModified description
83870view00:54, 18 December 2015KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
HES1GeneProductENSG00000114315 (Ensembl)
HEY1GeneProductENSG00000164683 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HIF1ANGeneProductENSG00000166135 (Ensembl)
MIR148ARnaMI0000253 (miRBase Sequence)
MIR31GeneProductMI0000089 (miRBase Sequence)
VEGFAGeneProductENSG00000112715 (Ensembl)
VEGFBGeneProductENSG00000173511 (Ensembl)
VEGFCGeneProductENSG00000150630 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3593"
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