Photodynamic therapy-induced HIF-1 survival signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none XSurvivalBIRC5PTGS2BCL2A1MCL1BCL2L1ROS / HypoxiaARNTHIF1APFKLSLC16A1LDHAPDHA1PKM2PGK1SLC2A1HK1SLC2A3GlycolysisHIF1ANEGLN1HIF1AXProliferationIGFBP1IGFBP2VEGFATGFATGFB3IGFBP3SERPINE1EDN1NOS2PTGS2ANGPT1VEGFATGFB3TGFAEPOANGPT2AngiogenesisGene transcriptionApoptosisBNIP3BNIP3LBIDPMAIP1TP53BAXBAK1Name: Photodynamic therapy-induced HIF-1 survival signalingOrganism: Homo sapiens


Description

Photodynamic therapy may induce a hypoxic survival response mediated by HIF-1.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3614).

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. Weijer R, Broekgaarden M, van Golen RF, Bulle E, Nieuwenhuis E, Jongejan A, Moerland PD, van Kampen AH, van Gulik TM, Heger M; ''Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.''; BMC Cancer, 2015 PubMed Europe PMC Scholia
  2. Broekgaarden M, Weijer R, van Gulik TM, Hamblin MR, Heger M; ''Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies.''; Cancer Metastasis Rev, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137133
Approved
view23:11, 27 February 2025KhanspersModified description
136861view03:04, 25 February 2025EweitzClear cache
136860view03:03, 25 February 2025EweitzEconomize layout
106542
CPTAC
view00:08, 6 September 2019KhanspersModified description
105513view06:03, 8 August 2019KhanspersModified description
89311view10:31, 1 September 2016Mkutmonfix uniprot identifier for PDHA1
88315view15:37, 1 August 2016FehrhartOntology Term : 'altered regulatory pathway' added !
86062view23:29, 28 June 2016KhanspersOntology Term : 'cancer' added !
85988view19:25, 22 June 2016KhanspersModified title
84550view19:25, 1 March 2016MaintBotgrouped HIF1A and ARNT
84545view19:11, 1 March 2016MaintBotConnected interactions and created groups
84534view20:07, 29 February 2016Ruudweijer
84533view20:05, 29 February 2016RuudweijerAdded reference.
84497view07:33, 26 February 2016RuudweijerModified description
84496view07:32, 26 February 2016RuudweijerModified description
84495view07:31, 26 February 2016RuudweijerModified title
84460view18:13, 25 February 2016RuudweijerNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ANGPT1GeneProduct284 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ARNTGeneProduct405 (Entrez Gene)
BAK1GeneProduct578 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCL2A1GeneProduct597 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
BIDGeneProduct637 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BNIP3GeneProduct664 (Entrez Gene)
BNIP3LGeneProduct665 (Entrez Gene)
EDN1GeneProduct1906 (Entrez Gene)
EGLN1GeneProduct54583 (Entrez Gene)
EPOGeneProduct2056 (Entrez Gene)
HIF1AGeneProduct3091 (Entrez Gene)
HIF1ANGeneProduct55662 (Entrez Gene)
HK1GeneProduct3098 (Entrez Gene)
IGFBP1GeneProduct3484 (Entrez Gene)
IGFBP2GeneProduct3485 (Entrez Gene)
IGFBP3GeneProduct3486 (Entrez Gene)
LDHAGeneProduct3939 (Entrez Gene)
MCL1GeneProduct4170 (Entrez Gene)
NOS2GeneProduct4843 (Entrez Gene)
PDHA1ProteinP08559 (Uniprot-TrEMBL)
PFKLGeneProduct5211 (Entrez Gene)
PGK1GeneProduct5230 (Entrez Gene)
PKM2GeneProduct5315 (Entrez Gene)
PMAIP1GeneProduct5366 (Entrez Gene)
PTGS2GeneProduct5743 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SLC16A1GeneProduct6566 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A3GeneProduct6515 (Entrez Gene)
TGFAGeneProduct7039 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
VEGFAGeneProduct7422 (Entrez Gene)

Annotated Interactions

No annotated interactions

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