lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ChemotherapyTransporterexpressionImpaired drug expulsionCell survivalHCC cellsDrug-resistantcancer cellsWNT6G0/G1 cell cycle arrestHIF1AMEG3linc-RoRMRULHOTAIRAK126698Apoptosislinc-VLDLRUCA1Cell proliferationP-gpp21Bcl-xlTP53HypoxiaRecipient cellsEVsEV linc-RoREV linc-VLDLRName: lncRNA-mediated mechanisms of therapeutic resistanceOrganism: Homo sapiens


Description

LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.

This pathway is based on Fig 6 from [Parasramka et al](http://www.ncbi.nlm.nih.gov/pubmed/27013343).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3672).

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137136
Approved
view23:13, 27 February 2025KhanspersModified description
123394view06:24, 23 July 2022EgonwMade a pathway clickable
117771
CPTAC
view13:56, 22 May 2021EweitzModified title
108191view10:55, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106632view20:56, 12 September 2019KhanspersModified description
105511view06:02, 8 August 2019KhanspersModified description
96967view01:39, 24 April 2018AlexanderPicocondensed layout
87395view11:05, 22 July 2016MaintBotadded missing graphids
86056view23:01, 28 June 2016KhanspersModified description
86053view21:46, 28 June 2016KhanspersOntology Term : 'antineoplastic drug pathway' added !
86052view21:44, 28 June 2016KhanspersOntology Term : 'long non-coding RNA pathway' added !
86051view21:43, 28 June 2016KhanspersOntology Term : 'hepatocellular carcinoma' added !
86050view21:41, 28 June 2016Khanspersupdated data node color and type
86049view21:40, 28 June 2016KhanspersModified description
86048view21:39, 28 June 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AK126698RnaENSG00000203601 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
Bcl-xlGeneProductENSG00000171552 (Ensembl)
Cell proliferationPathway
EV linc-RoRRnaENSG00000258609 (Ensembl)
EV linc-VLDLRRna401491 (Entrez Gene)
G0/G1 cell cycle arrestPathway
HIF1AGeneProductENSG00000100644 (Ensembl)
HOTAIRRnaENSG00000228630 (Ensembl)
MEG3RnaENSG00000214548 (Ensembl)
MRULRna
P-gpGeneProductENSG00000085563 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCA1RnaENSG00000214049 (Ensembl)
WNT6GeneProductENSG00000115596 (Ensembl)
linc-RoRRnaENSG00000258609 (Ensembl)
linc-VLDLRRna401491 (Entrez Gene)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

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