lncRNA-mediated mechanisms of therapeutic resistance (Homo sapiens)

From WikiPathways

Description

LncRNA-mediated mechanisms of therapeutic resistance. Mechanisms of tumor cell resistance to chemotherapy or hypoxia involving lncRNA include modulation of drug transporters and elimination, survival signaling pathways, cell cycle progression and DNA repair, sensitization to apoptosis, and modulation of intercellular communication mediated by extracellular vesicles.

This pathway is based on Fig 6 from [Parasramka et al](http://www.ncbi.nlm.nih.gov/pubmed/27013343).

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3672).

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Ontology Terms

Pathway Ontology : oxidative stress response pathway signaling pathway

Bibliography

Parasramka MA, Maji S, Matsuda A, Yan IK, Patel T; ''Long non-coding RNAs as novel targets for therapy in hepatocellular carcinoma.''; Pharmacol Ther, 2016 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137136	view	23:13, 27 February 2025	Khanspers	Modified description
123394	view	06:24, 23 July 2022	Egonw	Made a pathway clickable
117771	view	13:56, 22 May 2021	Eweitz	Modified title
108191	view	10:55, 29 November 2019	Fehrhart	Ontology Term : 'cancer pathway' added !
106632	view	20:56, 12 September 2019	Khanspers	Modified description
105511	view	06:02, 8 August 2019	Khanspers	Modified description
96967	view	01:39, 24 April 2018	AlexanderPico	condensed layout
87395	view	11:05, 22 July 2016	MaintBot	added missing graphids
86056	view	23:01, 28 June 2016	Khanspers	Modified description
86053	view	21:46, 28 June 2016	Khanspers	Ontology Term : 'antineoplastic drug pathway' added !
86052	view	21:44, 28 June 2016	Khanspers	Ontology Term : 'long non-coding RNA pathway' added !
86051	view	21:43, 28 June 2016	Khanspers	Ontology Term : 'hepatocellular carcinoma' added !
86050	view	21:41, 28 June 2016	Khanspers	updated data node color and type
86049	view	21:40, 28 June 2016	Khanspers	Modified description
86048	view	21:39, 28 June 2016	Khanspers	New pathway

External references

DataNodes

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Name	Type	Database reference
AK126698	Rna	ENSG00000203601 (Ensembl)
Apoptosis	Pathway	WP254 (WikiPathways)
Bcl-xl	GeneProduct	ENSG00000171552 (Ensembl)
Cell proliferation	Pathway
EV linc-RoR	Rna	ENSG00000258609 (Ensembl)
EV linc-VLDLR	Rna	401491 (Entrez Gene)
G0/G1 cell cycle arrest	Pathway
HIF1A	GeneProduct	ENSG00000100644 (Ensembl)
HOTAIR	Rna	ENSG00000228630 (Ensembl)
MEG3	Rna	ENSG00000214548 (Ensembl)
MRUL	Rna
P-gp	GeneProduct	ENSG00000085563 (Ensembl)
TP53	GeneProduct	ENSG00000141510 (Ensembl)
UCA1	Rna	ENSG00000214049 (Ensembl)
WNT6	GeneProduct	ENSG00000115596 (Ensembl)
linc-RoR	Rna	ENSG00000258609 (Ensembl)
linc-VLDLR	Rna	401491 (Entrez Gene)
p21	GeneProduct	ENSG00000124762 (Ensembl)