Physico-chemical features and toxicity-associated pathways (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Adhesion migrationActin polymerisationPancreatic cancerAmyotrophic lateral sclerosis (ALS)ErbB singaling pathwayReceptor ubiquiltylationLong-term depressionDegradationCell cycleDNARegulation of Actin cytoskeletonDisturbance of mitochondrial respirationFocal adhesionScaffoldCellular targetsWnt signaling pathwayO2CBLCa2+PeroxynitriteNOFZD1FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9FZD10ACTA1PLCGCAMKARP3ARP2GRB2STAT5SOS1ArginineDVL1ELKJUNMLCPCTNNB1PP2AAPCROCK2Shc1MYCWNT16NEFHNEFMNEFLPKB/AKTAXIN1RafRasPAKPI3KMEKSOD1FAKGSK3BFN1DAAM1JNKNCKRHOAGluRp21p27GPX1NOS1GlutamateMLCMAPK/ERKJNKKTGFAWNT11PFN1PFN2PFN3PFN4TMSB4Cell CycleSrcMLCKNOS1SOD1SOD1NOROSOHH20Ca2+ErbB-1ErbB-2ErbB-4Name: Physico-chemical features and toxicity-associated pathwaysOrganism: Homo sapiens


Description

This pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography).

These 3 pathways demonstrate close links between pathways associated with chemical hits and pathways associated with toxicity. The pathways associated with chemical hits (Wnt signaling, long-term depression, and ErbB signaling pathways) and the pathways associated with toxicity (focal adhesion, ALS, and pancreatic Cancer respectively) have been shown to have possible links through shared genes between the two pathways. The mechanisms of action presented by these links were only implied by the toxicity pathways.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3680).

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access
Image:Wplogo_31.pngCommunity: PancCanNet

Ontology Terms

Pathway Ontology : flavonoid biosynthetic pathway
 

Bibliography

  1. Antczak P, Ortega F, Chipman JK, Falciani F; ''Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.''; PLoS One, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137962
Approved
view20:56, 10 March 2025KhanspersModified description
123395
PancCanNet
view06:24, 23 July 2022EgonwMade a pathway clickable
117651view11:45, 22 May 2021EweitzModified title
106306view17:45, 20 August 2019KhanspersModified description
106167view12:06, 16 August 2019MaintBotHMDB identifier normalization
105537view06:05, 9 August 2019KhanspersModified description
96435view07:49, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
90113view21:26, 13 October 2016Khanspersoverhaul
90112view20:38, 13 October 2016KhanspersModified title
88751view18:36, 14 August 2016AAR&CoFixed Unonnected Line
88750view18:34, 14 August 2016AAR&CoOntology Term : 'pancreatic cancer' added !
88749view18:33, 14 August 2016AAR&CoOntology Term : 'amyotrophic lateral sclerosis disease pathway' added !
88748view18:32, 14 August 2016AAR&CoModified title
88535view00:46, 11 August 2016AAR&CoOntology Term : 'signaling pathway' added !
88530view00:26, 11 August 2016AAR&CoPeriodical save, work in progress
88528view00:19, 11 August 2016AAR&CoModify Datanode
88526view00:16, 11 August 2016AAR&CoPeriodical save, work in progress
88522view00:06, 11 August 2016AAR&CoPeriodical save, work in progress
88521view23:58, 10 August 2016AAR&CoModify Datanodes
88519view23:56, 10 August 2016AAR&CoPeriodical save, work in progress
88516view23:53, 10 August 2016AAR&CoModify Datanodes
88515view23:51, 10 August 2016AAR&CoModify Datanodes
88513view23:48, 10 August 2016AAR&CoModify Datanode
88511view23:25, 10 August 2016AAR&CoModify Datanoed
88510view23:22, 10 August 2016AAR&CoModify Datanode
88507view23:18, 10 August 2016AAR&CoPeriodical save, work in progress
88504view23:04, 10 August 2016AAR&CoModify Datanode
88500view22:58, 10 August 2016AAR&CoModify Datanode
88495view22:48, 10 August 2016AAR&CoModify Datanode
88494view22:44, 10 August 2016AAR&CoPeriodical save, work in progress
88492view22:43, 10 August 2016AAR&CoModify Datanode
88488view22:32, 10 August 2016AAR&CoModified description
88487view22:28, 10 August 2016AAR&CoModified description
88482view22:22, 10 August 2016AAR&CoModify Datanodes
87131view18:49, 18 July 2016AAR&CoFixed Unconnected Lines
86140view13:23, 1 July 2016AAR&CoModified description
86139view13:23, 1 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTA1GeneProductENSG00000143632 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARP2GeneProductENSG00000138071 (Ensembl)
ARP3GeneProductENSG00000115091 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
ArginineMetaboliteHMDB0000517 (HMDB)
CAMK GeneProductENSG00000134072 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cell CyclePathwayWP179 (WikiPathways)
DAAM1GeneProductENSG00000100592 (Ensembl) assists in formation of Dvl-Rho complex
DVL1GeneProductENSG00000107404 (Ensembl)
ELKGeneProductENSG00000126767 (Ensembl)
ErbB-1GeneProductENSG00000146648 (Ensembl)
ErbB-2GeneProductENSG00000141736 (Ensembl)
ErbB-4GeneProductENSG00000178568 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
  • PRK2
  • Focal adhesion kinase
FN1GeneProductENSG00000115414 (Ensembl)
FZD10GeneProductENSG00000111432 (Ensembl)
FZD1GeneProductENSG00000157240 (Ensembl)
FZD2GeneProductENSG00000180340 (Ensembl)
FZD3GeneProductENSG00000104290 (Ensembl)
FZD4GeneProductENSG00000174804 (Ensembl)
FZD5GeneProductENSG00000163251 (Ensembl)
FZD6GeneProductENSG00000164930 (Ensembl)
FZD7GeneProductENSG00000155760 (Ensembl)
FZD8GeneProductENSG00000177283 (Ensembl)
FZD9GeneProductENSG00000188763 (Ensembl)
GPX1GeneProductENSG00000233276 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
GluRGeneProductP42261 (Uniprot-TrEMBL) General glutamate receptor
Glutamate MetaboliteHMDB0060475 (HMDB)
H20MetaboliteCHEBI:15377 (ChEBI)
JNKGeneProductENSG00000107643 (Ensembl)
JNKKGeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MAPK/ERKGeneProductENSG00000100030 (Ensembl)
MEK GeneProductENSG00000169032 (Ensembl)
MLCGeneProductENSG00000168530 (Ensembl)
MLCKGeneProductENSG00000065534 (Ensembl) myosin light chain kinase
MLCPGeneProductENSG00000228868 (Ensembl) myosin-light chain phosphatase
MYCGeneProductENSG00000136997 (Ensembl)
NCKGeneProductENSG00000158092 (Ensembl)
NEFHGeneProductENSG00000100285 (Ensembl)
NEFLGeneProductENSG00000277586 (Ensembl)
NEFMGeneProductENSG00000104722 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NOS1GeneProductENSG00000089250 (Ensembl)
O2MetaboliteCHEBI:15379 (ChEBI)
OHMetaboliteCHEBI:16234 (ChEBI)
PAKGeneProductENSG00000149269 (Ensembl)
PFN1GeneProductENSG00000108518 (Ensembl)
PFN2GeneProductENSG00000070087 (Ensembl)
PFN3GeneProductENSG00000196570 (Ensembl)
PFN4GeneProductENSG00000176732 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl)
PKB/AKTGeneProductENSG00000142208 (Ensembl)
PLCGGeneProductENSG00000124181 (Ensembl)
PP2AGeneProductENSG00000113575 (Ensembl)
PeroxynitriteMetaboliteHMDB0002179 (HMDB)
RHOAGeneProductENSG00000067560 (Ensembl)
ROCK2GeneProductENSG00000134318 (Ensembl)
ROSMetaboliteHMDB0003125 (HMDB)
RafGeneProductENSG00000132155 (Ensembl)
RasGeneProductENSG00000132155 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT5GeneProductENSG00000126561 (Ensembl)
Shc1 GeneProductENSG00000160691 (Ensembl)
Src GeneProductENSG00000197122 (Ensembl)
TGFAGeneProductENSG00000163235 (Ensembl)
TMSB4GeneProductP62328 (Uniprot-TrEMBL)
WNT11GeneProductENSG00000085741 (Ensembl)
WNT16GeneProductENSG00000002745 (Ensembl)
p21GeneProductENSG00000124762 (Ensembl)
p27GeneProductENSG00000111276 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3680"
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