Wnt signaling pathway (Rattus norvegicus)

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1PalmitoylationNU->CYERDDTranslocationPM->CYNUDeacetylationProteins in a complex interactionPlasma membraneDCY->PMDeubiquitinationCY->NUCY->PMCY->NUSumoylationPhosphorylationGODReaction through unknowm mechanisms/moleculesGolgi apparatusComplex formationCY->NUENExtracellularCY->NUDCY->PMDephosphorylationDEnzyme ComplexAcetylation(Protein-protein interaction)ActivationUbiquitinationMolecular AssociationDDemethylationDCytoplasmEndoplasmic reticulumCYNucleusGene SymbolMTReceptorControlMolecule in the pathwayMethylationLigandGlycosylationPMInhibitionProteolytic cleavageAccession Number: NetPath 8; cellmap:8MitochondrionECRecruitmentAutophosphorylationDCY->NUCY->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


Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NetPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, pleaes cite the Cancer Cell Map and NetPath websites until the pathway is published.

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  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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120572view10:27, 17 December 2021EweitzModified description
120571view10:27, 17 December 2021EweitzModified title
117978view11:19, 23 May 2021EweitzModified title
117024view11:38, 16 May 2021EweitzModified title
115999view15:56, 28 March 2021EgonwCopied the NetPath paper to the literature list.
115981view18:10, 23 March 2021EgonwModified description
83028view02:01, 18 November 2015MkutmonFix outdated identifiers
71790view20:33, 17 October 2013MaintBotAutomated update of data sources
69401view19:00, 8 July 2013MaintBotUpdated to 2013 gpml schema
67760view11:59, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
41722view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
35028view09:17, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35020view09:10, 11 February 2010ThomasModified description
34098view19:18, 9 December 2009MaintBotAutomatic update of empty xrefs
22594view13:42, 14 November 2008ThomasChanged pathway title (was duplicate of WP564)
21467view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Wnt NetPath 8]] moved to [[Pathway:WP375]]: Moved to stable identifier
8486view13:46, 7 January 2008MaintBot[[Pathway:Rat:Wnt NetPath 8]] moved to [[Pathway:Rattus norvegicus:Wnt NetPath 8]]: Renaming species
7859view16:23, 18 December 2007MaintBotfixed category names
7315view12:42, 4 November 2007MaintBotAdded categories to GPML
6609view22:20, 22 May 2007A.Pandeygpml file for [[Rat:Wnt_NetPath_8]]

External references


View all...
NameTypeDatabase referenceComment
Akt1GeneProduct24185 (Entrez Gene)
ApcGeneProduct24205 (Entrez Gene)
Arrb1GeneProduct25387 (Entrez Gene)
Arrb2GeneProduct25388 (Entrez Gene)
Axin1GeneProduct79257 (Entrez Gene)
Axin2GeneProduct29134 (Entrez Gene)
Bcl9GeneProductENSRNOG00000017516 (Ensembl)
Brd7GeneProduct361374 (Entrez Gene)
BtrcGeneProduct361765 (Entrez Gene)
CRYBB2GeneProduct25422 (Entrez Gene)
Camk2aGeneProduct25400 (Entrez Gene)
Camk2bGeneProduct24245 (Entrez Gene)
Camk2dGeneProduct24246 (Entrez Gene)
Camk2gGeneProduct171140 (Entrez Gene)
Ccnd1GeneProduct58919 (Entrez Gene)
Cdc25cGeneProduct307511 (Entrez Gene)
Cdc2aGeneProduct54237 (Entrez Gene)
Cdh1GeneProduct83502 (Entrez Gene)
Csnk1a1GeneProduct113927 (Entrez Gene)
Csnk1dGeneProduct64462 (Entrez Gene)
Csnk1eGeneProduct58822 (Entrez Gene)
Csnk2a1GeneProduct116549 (Entrez Gene)
Csnk2a2GeneProduct307641 (Entrez Gene)
Csnk2bGeneProduct81650 (Entrez Gene)
Ctbp1GeneProduct29382 (Entrez Gene)
Ctbp2GeneProduct81717 (Entrez Gene)
Ctnnb1GeneProduct84353 (Entrez Gene)
Cul1GeneProduct362356 (Entrez Gene)
Cxxc4GeneProduct83824 (Entrez Gene)
DVL2GeneProduct303251 (Entrez Gene)
Daam1GeneProduct314212 (Entrez Gene)
Dab2GeneProduct79128 (Entrez Gene)
Dkk1GeneProduct293897 (Entrez Gene)
Dlgh1GeneProduct25252 (Entrez Gene)
Dlgh2GeneProduct64053 (Entrez Gene)
Dlgh4GeneProduct29495 (Entrez Gene)
Dvl1GeneProduct83721 (Entrez Gene)
Dvl3GeneProduct303811 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
FZD7GeneProduct301440 (Entrez Gene)
Fhl2GeneProduct63839 (Entrez Gene)
Fzd1GeneProduct58868 (Entrez Gene)
Fzd2GeneProduct64512 (Entrez Gene)
Fzd4GeneProduct64558 (Entrez Gene)
Fzd5GeneProduct317674 (Entrez Gene)
Fzd6GeneProduct282581 (Entrez Gene)
Fzd9GeneProduct266608 (Entrez Gene)
Gsk3bGeneProduct84027 (Entrez Gene)
HIPK2GeneProduct362342 (Entrez Gene)
JunGeneProduct24516 (Entrez Gene)
JupGeneProduct81679 (Entrez Gene)
LOC500430GeneProduct500430 (Entrez Gene)
LOC503000GeneProduct503000 (Entrez Gene)
Lef1GeneProduct161452 (Entrez Gene)
Lrp1GeneProduct299858 (Entrez Gene)
Lrp5GeneProduct293649 (Entrez Gene)
Lrp6GeneProduct312781 (Entrez Gene)
MGC112790GeneProduct364754 (Entrez Gene)
MYBGeneProduct293405 (Entrez Gene)
Magi3GeneProduct245903 (Entrez Gene)
Map1bGeneProduct29456 (Entrez Gene)
Map3k7GeneProduct313121 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
Mapk3GeneProduct50689 (Entrez Gene)
Mapk8GeneProduct116554 (Entrez Gene)
Mapk8ipGeneProduct116457 (Entrez Gene)
Mapk9GeneProduct50658 (Entrez Gene)
Mark2GeneProduct60328 (Entrez Gene)
Nkd1GeneProduct364952 (Entrez Gene)
Nr5a1GeneProduct83826 (Entrez Gene)
Pax2GeneProduct293992 (Entrez Gene)
Pias4GeneProduct362827 (Entrez Gene)
Pin1GeneProduct298696 (Entrez Gene)
Ppp2caGeneProduct24672 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
Prkcb1GeneProduct25023 (Entrez Gene)
PrkccGeneProduct24681 (Entrez Gene)
RGD1561602GeneProduct497961 (Entrez Gene)
Rac1GeneProduct363875 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
RhoaGeneProduct117273 (Entrez Gene)
Ror2GeneProduct306782 (Entrez Gene)
Runx2GeneProduct367218 (Entrez Gene)
Ruvbl1GeneProduct65137 (Entrez Gene)
SOX9GeneProduct140586 (Entrez Gene)
Sall1GeneProduct307740 (Entrez Gene)
Senp2GeneProduct78973 (Entrez Gene)
Sfrp1GeneProduct84402 (Entrez Gene)
Sfrp2GeneProduct310552 (Entrez Gene)
Skp1aGeneProduct287280 (Entrez Gene)
Smad3GeneProduct25631 (Entrez Gene)
Smad4GeneProductENSRNOG00000051965 (Ensembl)
Sumo1GeneProduct301442 (Entrez Gene)
TAX1BP3GeneProduct360564 (Entrez Gene)
TbpGeneProduct117526 (Entrez Gene)
Tcf4GeneProduct84382 (Entrez Gene)
Tcfap2aGeneProduct306862 (Entrez Gene)
Tcfe2aGeneProduct171046 (Entrez Gene)
Vangl2GeneProduct289229 (Entrez Gene)
Wnt1GeneProduct24881 (Entrez Gene)
Wnt2GeneProduct114487 (Entrez Gene)
Wnt3GeneProduct24882 (Entrez Gene)
Wnt3aGeneProduct303181 (Entrez Gene)
Wnt4GeneProduct84426 (Entrez Gene)
Wnt5aGeneProduct64566 (Entrez Gene)
Wnt7aGeneProduct114850 (Entrez Gene)

Annotated Interactions

No annotated interactions

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