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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Col3a1 Flot2 Col1a2 Ccnd2 Mtor PI3K/AKT signaling Col5a3 Sos1 Socs1 mmu-miR-155-5p Fasn Acaca Bcl2l11 Eif4e2 Prkx Crkl mmu-miR-15a-5p Col4a2 Mapk3 mmu-miR-29a-3p mmu-miR-16-5p Pik3r3 Exoc7 Bcl2 Insulin signaling mmu-miR-503-5p Bad Pik3r1 Col1a1 mmu-miR-425-5p Rheb Cdkn1b Prkar2a mmu-miR-29b-3p Raf1 Name: Dysregulated miRNA targeting in insulin/PI3K-AKT signaling Organism: Mus musculus
Description
This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.
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Quality Tags
Open Access This pathway is based on a pathway published in an Open Access journal.
Approved version The current version of this pathway was approved for data analysis by Eric Weitz .
Annotated lists Comment: This pathway depicts miRNA targeting of proteins related to specific pathways.
Annotated lists of gene products are considered useful for analysis and for stimulating future pathway curation.
Ontology Terms
Bibliography
Kwon DN, Chang BS, Kim JH; ''MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia History
External references
DataNodes
Annotated Interactions
No annotated interactions
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