Dysregulated miRNA targeting in insulin/PI3K-AKT signaling (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Col3a1Flot2Col1a2Ccnd2MtorPI3K/AKT signalingCol5a3Sos1Socs1mmu-miR-155-5pFasnAcacaBcl2l11Eif4e2PrkxCrklmmu-miR-15a-5pCol4a2Mapk3mmu-miR-29a-3pmmu-miR-16-5pPik3r3Exoc7Bcl2Insulin signalingmmu-miR-503-5pBadPik3r1Col1a1mmu-miR-425-5pRhebCdkn1bPrkar2ammu-miR-29b-3pRaf1Name: Dysregulated miRNA targeting in insulin/PI3K-AKT signalingOrganism: Mus musculus


Description

This pathway is modeled after figure 4b from kwon et al. Expression of specific miRNA in Cmah-null mice (mice that develop fasting hyperglycemia, glucose intolerance, and characteristics of type 2 diabetes after being fed a high fat diet) are disregulated, leading to the development of complications. The disregulated miRNA influence the expression of their target genes through interaction with the Insulin signaling and the PI3K/AKT signalling pathways.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version
Image:NonTypical.pngAnnotated lists

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Kwon DN, Chang BS, Kim JH; ''MicroRNA dysregulation in liver and pancreas of CMP-Neu5Ac hydroxylase null mice disrupts insulin/PI3K-AKT signaling.''; Biomed Res Int, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128795
Approved
view01:43, 22 February 2024EweitzStandardize case
123115view07:06, 4 July 2022EgonwMade two pathways clickable
116445view09:51, 7 May 2021EweitzModified title
89747view23:54, 29 September 2016KhanspersModified title
89746view23:53, 29 September 2016KhanspersModified title
89644view23:42, 22 September 2016Khansperscorrected direction of miRNA-target interactions
88610view23:00, 11 August 2016AAR&CoAdded Data Node
88609view22:58, 11 August 2016AAR&CoAdded DataNode
87414view11:31, 22 July 2016MkutmonOntology Term : 'regulatory pathway' added !
87257view14:22, 20 July 2016AAR&CoOntology Term : 'type 2 diabetes mellitus' added !
87256view14:22, 20 July 2016AAR&CoOntology Term : 'glucose intolerance' added !
87255view14:21, 20 July 2016AAR&CoModified description
87254view14:09, 20 July 2016AAR&CoAdded Citation
87253view13:51, 20 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AcacaGeneProductENSMUSG00000020532 (Ensembl)
BadGeneProductENSMUSG00000024959 (Ensembl)
Bcl2GeneProductENSMUSG00000057329 (Ensembl)
Bcl2l11GeneProductENSMUSG00000027381 (Ensembl)
Ccnd2GeneProductENSMUSG00000000184 (Ensembl)
Cdkn1bGeneProductENSMUSG00000003031 (Ensembl)
Col1a1GeneProductENSMUSG00000001506 (Ensembl)
Col1a2GeneProductENSMUSG00000029661 (Ensembl)
Col3a1GeneProductENSMUSG00000026043 (Ensembl)
Col4a2GeneProductENSMUSG00000031503 (Ensembl)
Col5a3GeneProductENSMUSG00000004098 (Ensembl)
CrklGeneProductENSMUSG00000006134 (Ensembl)
Eif4e2GeneProductENSMUSG00000026254 (Ensembl)
Exoc7GeneProductENSMUSG00000020792 (Ensembl)
FasnGeneProductENSMUSG00000025153 (Ensembl)
Flot2GeneProductENSMUSG00000061981 (Ensembl)
Insulin signalingPathwayWP65 (WikiPathways)
Mapk3GeneProductENSMUSG00000063065 (Ensembl)
MtorGeneProductENSMUSG00000028991 (Ensembl)
PI3K/AKT signalingPathwayWP3675 (WikiPathways)
Pik3r1GeneProductENSMUSG00000041417 (Ensembl)
Pik3r3GeneProductENSMUSG00000028698 (Ensembl)
Prkar2aGeneProductENSMUSG00000032601 (Ensembl)
PrkxGeneProductENSMUSG00000035725 (Ensembl)
Raf1GeneProductENSMUSG00000000441 (Ensembl)
RhebGeneProductENSMUSG00000028945 (Ensembl)
Socs1GeneProductENSMUSG00000038037 (Ensembl)
Sos1GeneProductENSMUSG00000024241 (Ensembl)
mmu-miR-155-5pRnaMI0000177 (miRBase Sequence)
mmu-miR-15a-5pRnaMIMAT0000526 (miRBase Sequence)
mmu-miR-16-5pRnaMIMAT0000527 (miRBase Sequence)
mmu-miR-29a-3pRnaMIMAT0000535 (miRBase Sequence)
mmu-miR-29b-3pRnaMIMAT0000127 (miRBase Sequence)
mmu-miR-425-5pRnaMIMAT0004750 (miRBase Sequence)
mmu-miR-503-5pRnaMIMAT0003188 (miRBase Sequence)

Annotated Interactions

No annotated interactions

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