Apoptosis regulation by parathyroid hormone-related protein (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none siRNA Integrin A6Growth factor receptorsBCL-2 familyBCL2L10MCL-1BOKBCL2L12BCL2A1BCL2L15BIDBCL2L1BCL2L2BAK1BCL2L14BCL2BAXBCL2L13ApoptosisMYCPTHLHPI3-KITGA6ITGB4GSK3AGSK3BAKT1AKT2AKT3siRNA Integrin B4siRNA PIK3CAName: Apoptosis regulation by parathyroid hormone-related proteinOrganism: Homo sapiens


Description

This pathway is based on Figure 8 of "Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling."(See Bibliography). Intracrine PTHrP inhibits apoptosis by activating the PI3-K/Akt pathway by increasing levels of integrin A6B4, which signals in harmony with growth factor receptors. The activation of Akt increases the ratio of anti-apoptosis members to pro-apoptosis members in the Bcl-2 family. The activation of Akt deactivates GSK-3 which leads to higher levels of c-myc, therefore leading to lower levels of apoptosis. Overall, intracrine PTHrP has the effect of increased cell survival on C4-2 cells. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3872)

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : regulatory pathway
Disease : prostate cancer
 

Bibliography

  1. Bhatia V, Mula RV, Weigel NL, Falzon M; ''Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling.''; Mol Cancer Res, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137333
Approved
view19:17, 1 March 2025EweitzUse gene symbol
137332view19:14, 1 March 2025EweitzIncrease font size
137327view16:38, 1 March 2025EweitzModified title
137326view16:37, 1 March 2025EweitzUse gene symbols
137325view16:36, 1 March 2025EweitzEconomize layout
137223view09:01, 1 March 2025EgonwModified description
128597view01:26, 15 February 2024EweitzModified description
128596view01:22, 15 February 2024EweitzEconomize layout, standardize case
127930view22:43, 17 January 2024Khanspersupdated xrefs
123397view06:25, 23 July 2022EgonwMade a pathway clickable
116648view11:40, 9 May 2021EweitzModified title
106498view21:45, 4 September 2019KhanspersModified description
105802view22:50, 15 August 2019KhanspersModified description
89397view19:40, 10 September 2016AlexanderPicoModified title
89270view23:14, 28 August 2016Khansperstypo
89269view23:13, 28 August 2016Khanspersupdated layout and added BCL2 family
89268view19:13, 27 August 2016Khanspersreplaced label with pathwat node
89267view19:12, 27 August 2016Khanspersunified gene size, updated RNA node color, replaced label with gene
89104view14:28, 22 August 2016EgonwOntology Term : 'regulatory pathway' added !
89065view06:55, 19 August 2016FehrhartModified description
89064view06:53, 19 August 2016Fehrhartfixed greek characters in title
89063view06:50, 19 August 2016FehrhartMinor cosmetic changes
88798view20:40, 14 August 2016AAR&CoModified description
88797view20:39, 14 August 2016AAR&CoModified description
88796view20:38, 14 August 2016AAR&CoModified description
88795view20:36, 14 August 2016AAR&CoModified description
88794view20:32, 14 August 2016AAR&CoOntology Term : 'prostate cancer' added !
88793view20:31, 14 August 2016AAR&CoFix unconnected lines
88792view20:30, 14 August 2016AAR&CoModify Datanode
88789view20:06, 14 August 2016AAR&CoFix excess space
88787view20:03, 14 August 2016AAR&CoModify Datanode
88779view19:54, 14 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductAKT1 (HGNC)
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
Apoptosis PathwayWP254 (WikiPathways)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2A1GeneProductENSG00000140379 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl) Increases the ratio of anti-apoptosis members to pro-apoptosis members.
BCL2L10GeneProductENSG00000137875 (Ensembl)
BCL2L12GeneProductENSG00000126453 (Ensembl)
BCL2L13GeneProductENSG00000099968 (Ensembl)
BCL2L14GeneProductENSG00000121380 (Ensembl)
BCL2L15GeneProductENSG00000188761 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BCL2L2GeneProductENSG00000129473 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BOKGeneProductENSG00000176720 (Ensembl)
GSK3AGeneProductENSG00000105723 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
ITGA6GeneProductENSG00000091409 (Ensembl) "Integrin A6" originally
ITGB4GeneProductENSG00000132470 (Ensembl) "Integrin B4" originally
MCL-1ProteinQ07820 (Uniprot-TrEMBL)
MYCGeneProductENSG00000136997 (Ensembl)
PI3-KGeneProductENSG00000105851 (Ensembl)
PTHLHGeneProductENSG00000087494 (Ensembl) "Intracrine PTHrP" originally

Annotated Interactions

No annotated interactions

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