Proximal tubule transporters (Rattus norvegicus)

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1-4Na+ / H+ ExchangeNHE3NHE3 RegP1NHE3 RegP2NHE8CA IICA VIICA IVCA XIICA XIVCA XVPAT1SAT1OAT1OAT3NaPi-2aNaPi-2bPit-2NAS1NBCNaDC-1NaDC-3Atp1a1Atp1b1Atp1b3Gamma 1CHIFB*AT1E. Glutam. Tr.SNAT7LAT3-4F2hcOCTN2BAT-1LAT1-4F2hcLAT3-4F2hcTAT1Atp6v1aAtp6v1b1Atp6v1b2Atp6v1c1Atp6v1dAtp6v1e1Atp6v1fAtp6v1g1Atp6v1g3Atp6v1hAtp6v0a1Atp6v0a2Atp6v0a4Atp6v0bAtp6v0cAtp6v0d1Atp6v0d2Atp6v0e1Atp6v0e2Na-Anion CotransportH-ATPase V0 SubunitsH-ATPase V1 SubunitsCarbonic AnhydrasesNa/K-ATPase SubunitsAnion ExchangeNa-dependent Amino Acids TransportNa-independent Amino Acids Transport


The proximal tubule of the nephron reabsorbs approximately two-thirds of the Na filtered through the glomerulus. Na extrusion from the cell by the basolateral Na/K-ATPase provides the gradient for apical Na entry, and for reabsorption of glucose, phosphate, amino acids and other component of the ultrafiltrate. This pathway organizes several of the transporters present in the proximal tubule by their function and it is based in deep-sequencing and physiological data.

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Ontology Terms



  1. Curthoys NP, Moe OW; ''Proximal tubule function and response to acidosis.''; Clin J Am Soc Nephrol, 2014 PubMed Europe PMC Scholia
  2. Purkerson JM, Schwartz GJ; ''The role of carbonic anhydrases in renal physiology.''; Kidney Int, 2007 PubMed Europe PMC Scholia
  3. Markovich D, Aronson PS; ''Specificity and regulation of renal sulfate transporters.''; Annu Rev Physiol, 2007 PubMed Europe PMC Scholia
  4. Lee JW, Chou CL, Knepper MA; ''Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes.''; J Am Soc Nephrol, 2015 PubMed Europe PMC Scholia


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117007view11:21, 16 May 2021EweitzModified title
94666view13:22, 4 October 2017AgustinGVOntology Term : 'kidney proximal convoluted tubule epithelial cell' added !
89611view13:36, 20 September 2016AgustinGVModified description
89599view16:02, 19 September 2016AgustinGVOntology Term : 'epithelial cell of proximal tubule' added !
89124view19:21, 22 August 2016Khanspersfixing broken literature references
89123view19:19, 22 August 2016Khanspers
89103view14:16, 22 August 2016AgustinGVcorrect misalignment
88956view21:18, 17 August 2016AgustinGVSpecify description
88955view21:14, 17 August 2016AlexanderPicoMinor updates to labels and layout
88949view21:00, 17 August 2016AgustinGVSpecify description
88948view19:26, 17 August 2016AlexanderPicoOntology Term : 'transport pathway' added !
88947view19:26, 17 August 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
88946view19:25, 17 August 2016AlexanderPicoOntology Term : 'ion transport pathway' added !
88945view19:24, 17 August 2016AlexanderPicoOntology Term : 'nephron tubule epithelial cell' added !
88942view18:39, 17 August 2016AgustinGVupdate protein to gene product
88926view17:46, 17 August 2016AgustinGVModified description
88921view14:45, 17 August 2016AgustinGVSpecify description
88920view14:44, 17 August 2016AgustinGVModified description
88919view14:41, 17 August 2016AgustinGValigment
88918view14:39, 17 August 2016AgustinGV
88917view14:36, 17 August 2016AgustinGVH ATPase Vo
88916view14:33, 17 August 2016AgustinGVH ATPase V1 subs
88915view14:31, 17 August 2016AgustinGV
88914view14:27, 17 August 2016AgustinGV
88911view12:35, 17 August 2016AgustinGVUpdate AA transporters
88892view21:28, 16 August 2016AgustinGVSpecify description
88891view21:26, 16 August 2016AgustinGVSpecify description
88890view21:25, 16 August 2016AgustinGVSpecify description
88889view21:20, 16 August 2016AgustinGVQuick edit to datanode annotation or property
88888view21:17, 16 August 2016AgustinGVReferences
88887view21:01, 16 August 2016AgustinGVQuick edit to datanode annotation or property
88882view20:53, 16 August 2016AgustinGVModified description
88881view20:52, 16 August 2016AgustinGVOntology Term : 'PW:0000001' removed !
88880view20:52, 16 August 2016AgustinGVOntology Term : 'Pathway Ontology' added !
88879view20:16, 16 August 2016AgustinGVSpecify description
88878view20:13, 16 August 2016AgustinGVUpdate Na-Anions simporters
88877view20:06, 16 August 2016AgustinGVUpdate Anion Exchangers
88876view20:03, 16 August 2016AgustinGVSpecify description
88875view20:00, 16 August 2016AgustinGVSpecify description
88874view19:56, 16 August 2016AgustinGVPeriodical save, work in progress
88873view19:49, 16 August 2016AgustinGVSpecify description
88872view19:46, 16 August 2016AgustinGVPeriodical save, work in progress
88871view19:44, 16 August 2016AgustinGVNew pathway

External references


View all...
NameTypeDatabase referenceComment
Atp1a1GeneProduct24211 (Entrez Gene)
Atp1b1GeneProduct25650 (Entrez Gene)
Atp1b3GeneProduct25390 (Entrez Gene)
Atp6v0a1 GeneProduct29757 (Entrez Gene)
Atp6v0a2 GeneProduct116455 (Entrez Gene)
Atp6v0a4 GeneProduct296981 (Entrez Gene)
Atp6v0b GeneProduct298451 (Entrez Gene)
Atp6v0c GeneProduct170667 (Entrez Gene)
Atp6v0d1 GeneProduct291969 (Entrez Gene)
Atp6v0d2 GeneProduct297932 (Entrez Gene)
Atp6v0e1 GeneProduct94170 (Entrez Gene)
Atp6v0e2GeneProduct436582 (Entrez Gene)
Atp6v1a GeneProduct685232 (Entrez Gene)
Atp6v1b1 GeneProduct312488 (Entrez Gene)
Atp6v1b2 GeneProduct117596 (Entrez Gene)
Atp6v1c1 GeneProduct299971 (Entrez Gene)
Atp6v1d GeneProduct299159 (Entrez Gene)
Atp6v1e1 GeneProduct297566 (Entrez Gene)
Atp6v1f GeneProduct116664 (Entrez Gene)
Atp6v1g1 GeneProduct298103 (Entrez Gene)
Atp6v1g3 GeneProduct289407 (Entrez Gene)
Atp6v1h GeneProduct297797 (Entrez Gene)
B*AT1GeneProduct664630 (Entrez Gene)
BAT-1GeneProduct116726 (Entrez Gene)
CA IIGeneProduct54231 (Entrez Gene)
CA IVGeneProduct29242 (Entrez Gene)
CA VIIGeneProduct291819 (Entrez Gene)
CA XIIGeneProduct363085 (Entrez Gene)
CA XIVGeneProduct791259 (Entrez Gene)
CA XVGeneProduct288360 (Entrez Gene)
CHIFGeneProduct64190 (Entrez Gene)
E. Glutam. Tr.GeneProduct25550 (Entrez Gene)
Gamma 1GeneProduct29639 (Entrez Gene)
LAT1-4F2hcGeneProduct83509 (Entrez Gene)
LAT3-4F2hcGeneProduct307811 (Entrez Gene)
LAT3-4F2hcGeneProduct84551 (Entrez Gene)
NAS1GeneProduct58980 (Entrez Gene)
NBCGeneProduct84484 (Entrez Gene)
NHE3 RegP1GeneProduct59114 (Entrez Gene)
NHE3 RegP2GeneProduct116501 (Entrez Gene)
NHE3GeneProduct24784 (Entrez Gene)
NHE8GeneProduct311651 (Entrez Gene)
NaDC-1GeneProduct65202 (Entrez Gene)
NaDC-3GeneProduct64846 (Entrez Gene)
NaPi-2aGeneProduct25548 (Entrez Gene)
NaPi-2bGeneProduct84395 (Entrez Gene)
OAT1GeneProduct29509 (Entrez Gene)
OAT3GeneProduct83500 (Entrez Gene)
OCTN2GeneProduct29726 (Entrez Gene)
PAT1GeneProduct301010 (Entrez Gene)
Pit-2GeneProduct29502 (Entrez Gene)
SAT1GeneProduct64076 (Entrez Gene)
SNAT7GeneProduct291840 (Entrez Gene)
TAT1GeneProduct170566 (Entrez Gene)

Annotated Interactions

No annotated interactions

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