Development and heterogeneity of the ILC family (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none CLPsCD4-CD4+NCR-NCR+CHILPILCpa4b7+NKpNKp: Natural killer progenitorILCp: Innate lymphoid cell progenitorPeripheryBone marrow/Fetal liverROR-gammatnegativeILC: Innate lymphoid cellCHILP: Common helper innate lymphoid precursorCLP: Common lymphoid progenitorCD127-NKILC1CD103+ILC1CD127+ILC2ILC3IFNGPLZFIL17AIL25IL18IL12AIL12BBCL11BGFI1GATA3RORAIL22IFNGTBX21IL15TNFIFNGGATA3IL7TCF1NFIL3ID2TOXIL15EOMESAHRTBX21RORCIL7IL1BIL23AID2NFIL3TOXIL13IL4AREGIL5IL9IL6IL23AIL1BTNFIFNGIL12AIL12BexILC3T-bet+ ILC1sGATA3+ ILC2sROR-gammat+ ILC3sIFNGIL33TSLPIL25CCR6+ T-bet+ILC3CCR6+LTi cellsID2NFIL3TBX21IL22IL17AILC: Innate lymphoid cellNCR: Natural cytotoxicity receptorsNK: Natural killerLegendName: Development and heterogeneity of the ILC familyOrganism: Homo sapiens


Description

Development and heterogeneity of the innate lymphoid cell (ILC) family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription factors and cytokines are involved in the development of the three groups of mature ILCs. All ILCs develop from CLPs, which can differentiate into NKps or CHILPs. CHILPs can further differentiate into LTi cells through α4β7+ populations or into other ILC populations through differentiation into ILCps. ILC1s express T-bet, are responsive to IL-12, and produce IFN-γ and/or TNF. ILC2s highly express GATA3, are responsive to IL-25, IL-33 and TSLP, and produce IL-4, IL-5, IL-9, IL-13 and amphiregulin. ILC3s express ROR-γt, are responsive to IL-1β and IL-23, and produce IL-17 and/or IL-22. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3893)

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Quality Tags

Image:Curated.pngApproved version
Image:Featured.pngReview changes for Featured
Image:PLoS_OpenAccess.pngOpen Access
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Lai DM, Shu Q, Fan J; ''The origin and role of innate lymphoid cells in the lung.''; Mil Med Res, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138091
Approved
view02:08, 14 March 2025EweitzOntology Term : 'natural killer cell' added !
138090
Featured
view02:08, 14 March 2025EweitzOntology Term : 'CL:0000623' removed !
138089view02:07, 14 March 2025EweitzUse gene symbol
138088view02:05, 14 March 2025EweitzEconomize layout
138087view02:03, 14 March 2025EweitzTailor node width, use gene symbol
138086view01:55, 14 March 2025EweitzIncrease font size
138085view01:52, 14 March 2025EweitzEconomize layout
138084view01:52, 14 March 2025EweitzRefine legend
138083view01:49, 14 March 2025EweitzUse gene symbol
138082view01:31, 14 March 2025EweitzImprove readability of cell type labels
137190view14:32, 28 February 2025EgonwModified description
135705view16:45, 27 October 2024EweitzUse gene symbols
129544view16:01, 10 May 2024EweitzOntology Term : '' added !
129543view16:00, 10 May 2024EweitzOntology Term : '' added !
129542view15:53, 10 May 2024EweitzOntology Term : 'innate lymphoid cell' added !
129335view09:09, 27 March 2024MkutmonOntology Term : 'regulatory pathway' added !
118859view21:19, 2 June 2021EweitzModified description
106386view21:24, 28 August 2019KhanspersModified description
105568view06:25, 9 August 2019KhanspersModified description
89702view20:46, 26 September 2016Khanspersconnected interaction
89701view20:45, 26 September 2016Khanspers
89700view19:32, 26 September 2016Khansperstidy and legend
89321view15:48, 1 September 2016KhanspersOntology Term : 'common lymphoid progenitor' added !
89320view15:47, 1 September 2016KhanspersModified description
89315view15:42, 1 September 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AHRGeneProductENSG00000106546 (Ensembl)
AREGGeneProductENSG00000109321 (Ensembl)
BCL11BGeneProductENSG00000127152 (Ensembl)
EOMESGeneProductENSG00000163508 (Ensembl)
GATA3GeneProductENSG00000107485 (Ensembl)
GFI1GeneProductENSG00000162676 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL23AGeneProductENSG00000110944 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL7GeneProductENSG00000104432 (Ensembl)
IL9GeneProductENSG00000145839 (Ensembl)
NFIL3GeneProductENSG00000165030 (Ensembl)
PLZFGeneProductENSG00000109906 (Ensembl)
RORAGeneProductENSG00000069667 (Ensembl)
RORCGeneProductENSG00000143365 (Ensembl) "ROR-gammat" originally
TBX21GeneProductENSG00000073861 (Ensembl) "T-bet" originally
TCF1GeneProductENSG00000135100 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TOXGeneProductENSG00000198846 (Ensembl)
TSLPGeneProductENSG00000145777 (Ensembl)

Annotated Interactions

No annotated interactions

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