Amino acid metabolism (Homo sapiens)

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Description

A complete overview of the metabolism of all 20 amino acids. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Amino Acid metabolism", WP662 revision 71177, with a 99.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
136171view14:20, 21 December 2024EgonwChanged to the ChEBI identifier
136170view12:28, 21 December 2024EgonwConverted labels into data nodes
136169view10:59, 21 December 2024EgonwConverted a metabolite Label to DataNode with identifier
136167view10:43, 21 December 2024EgonwThe linked ChEBI entry seems to have the correct stereochemistry
123124view18:51, 4 July 2022EgonwMade three pathways clickable
117062view14:23, 16 May 2021EweitzModified title
115752view11:42, 9 March 2021EgonwReplaced the WP id of a mouse pathway with the matching human pathway
107149view14:23, 17 September 2019MaintBotChEBI identifier normalization
106767view13:24, 17 September 2019MaintBotHMDB identifier normalization
105878view04:51, 16 August 2019KhanspersModified description
105525view05:59, 9 August 2019KhanspersModified description
96439view07:56, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
90737view23:26, 13 December 2016Khanspersupdated link to source pathway
90730view22:40, 13 December 2016KhanspersOntology Term : 'amino acid metabolic pathway' added !
90729view22:38, 13 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-oxo-glutarateMetaboliteCHEBI:16810 (ChEBI)
5-OH-TrpMetaboliteHMDB0000472 (HMDB)
AC007325.2GeneProductENSG00000277196 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125
AC068533.7GeneProductENSG00000249319 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084
ACAA1GeneProductENSG00000060971 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491
ACADMGeneProductENSG00000117054 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867
ACLYGeneProductENSG00000131473 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251
ACO2GeneProductENSG00000100412 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880
ACSS1GeneProductENSG00000154930 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988
ADH1CGeneProductENSG00000248144 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921
ADH4GeneProductENSG00000198099 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472
ADH5GeneProductENSG00000197894 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929
ADH7GeneProductENSG00000196344 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926
ALDH18A1GeneProductENSG00000059573 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908
ALDH1A1GeneProductENSG00000165092 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450
ALDH7A1GeneProductENSG00000164904 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186
AOC3GeneProductENSG00000131471 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797
AP002884.2GeneProductENSG00000255292 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175
ARG1GeneProductENSG00000118520 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070
ARG2GeneProductENSG00000081181 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806
ASNSGeneProductENSG00000070669 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929
ASS1GeneProductENSG00000130707 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090
AUHGeneProductENSG00000148090 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
AconitateMetaboliteHMDB0000072 (HMDB)
Ala-tRNAMetaboliteCHEBI:17732 (ChEBI)
AlanineMetaboliteHMDB0000161 (HMDB)
Arg-tRNAMetaboliteCHEBI:18366 (ChEBI)
ArginineMetaboliteHMDB0000517 (HMDB)
Arginino-succinateMetaboliteHMDB0000052 (HMDB)
AsparagineMetaboliteHMDB0000168 (HMDB)
AspartateMetaboliteHMDB0000191 (HMDB)
B-OH-butyrateMetaboliteHMDB0000011 (HMDB)
BCAT1GeneProductENSG00000060982 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861
BHMTGeneProductENSG00000145692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972
CADGeneProductENSG00000084774 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969
CBSGeneProductENSG00000160200 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285
CPS1GeneProductENSG00000021826 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996
CSGeneProductENSG00000062485 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529
CTHGeneProductENSG00000116761 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968
Carbamoyl-aspartateMetaboliteHMDB0000828 (HMDB)
CitrateMetaboliteHMDB0000094 (HMDB)
CitrullineMetaboliteHMDB0000904 (HMDB)
Creatine PMetaboliteHMDB0001511 (HMDB)
CystathionineMetaboliteHMDB0000099 (HMDB)
CysteineMetaboliteHMDB0000574 (HMDB)
DBHGeneProductENSG00000123454 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864
DDCGeneProductENSG00000132437 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876
DLDGeneProductENSG00000091140 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450
DLSTGeneProductENSG00000119689 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170
Dihydro-orotateMetaboliteHMDB0003349 (HMDB)
DopamineMetaboliteHMDB0000073 (HMDB)
EHHADHGeneProductENSG00000113790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964
EPRSGeneProductENSG00000136628 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838
EpinephrineMetaboliteHMDB0000068 (HMDB)
EthanolMetaboliteHMDB0000108 (HMDB)
FAHGeneProductENSG00000103876 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482
FARSBGeneProductENSG00000116120 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035
FHGeneProductENSG00000091483 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194
FTCDGeneProductENSG00000160282 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
Fatty acid metabolismPathwayWP357 (WikiPathways)
FumarateMetaboliteHMDB0000134 (HMDB)
G6PC2GeneProductENSG00000152254 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768
GCLMGeneProductENSG00000023909 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995
GLSGeneProductENSG00000115419 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752
GLUD1GeneProductENSG00000148672 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
GLULGeneProductENSG00000135821 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739
GOT1GeneProductENSG00000120053 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791
GOT2GeneProductENSG00000125166 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792
GPT2GeneProductENSG00000166123 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
GSRGeneProductENSG00000104687 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804
GSSGeneProductENSG00000100983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852
Glu-tRNAMetaboliteCHEBI:29157 (ChEBI)
GlucoseMetaboliteHMDB0000122 (HMDB)
GlutamateMetaboliteHMDB0000148 (HMDB)
GlutamineMetaboliteHMDB0000641 (HMDB)
GlycineMetaboliteHMDB0000123 (HMDB)
GstGeneProductNo homologues found for original id M:MGI:1309515
Guanidinoacetate PMetaboliteHMDB0003705 (HMDB)
GuanidinoacetateMetaboliteHMDB0000128 (HMDB)
HADHGeneProductENSG00000138796 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009
HALGeneProductENSG00000084110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
HCO3MetaboliteHMDB0003538 (HMDB)
HDCGeneProductENSG00000140287 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062
HIBADHGeneProductENSG00000106049 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802
HIBCHGeneProductENSG00000198130 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792
HMGCLGeneProductENSG00000117305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158
HMGCS2GeneProductENSG00000134240 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939
HNMTGeneProductENSG00000150540 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181
His-tRNAMetaboliteCHEBI:29155 (ChEBI)
HistamineMetaboliteHMDB0000870 (HMDB)
HistidineMetaboliteHMDB0000177 (HMDB)
HomocysteineMetaboliteHMDB0000742 (HMDB)
IARSGeneProductENSG00000196305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219
IDH1GeneProductENSG00000138413 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413
Ile-tRNAMetaboliteCHEBI:29160 (ChEBI)
Imidazole acetaldehydeMetaboliteHMDB0003905 (HMDB)
IndoleacetaldehydeMetaboliteHMDB0001190 (HMDB)
IndoleacetateMetaboliteHMDB0000197 (HMDB)
IsoleucineMetaboliteHMDB0000172 (HMDB)
Isovaleryl-CoAMetaboliteHMDB0001113 (HMDB)
LARS2GeneProductENSG00000011376 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973
LDHAGeneProductENSG00000134333 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759
LactateMetaboliteHMDB0000190 (HMDB)
Leu-tRNAMetaboliteCHEBI:16624 (ChEBI)
LeucineMetaboliteHMDB0000687 (HMDB)
MAOAGeneProductENSG00000189221 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915
MARS2GeneProductENSG00000247626 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136
MCCC1GeneProductENSG00000078070 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289
MDH1GeneProductENSG00000014641 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051
MDH2GeneProductENSG00000146701 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050
MPSTGeneProductENSG00000128309 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733
MUTGeneProductENSG00000146085 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239
MalateMetaboliteHMDB0000156 (HMDB)
MelaninMetaboliteHMDB0004068 (HMDB)
Met-tRNAMetaboliteCHEBI:16635 (ChEBI)
MethionineMetaboliteHMDB0000696 (HMDB)
Methyl-OH-butyryl-CoAMetaboliteHMDB0001356 (HMDB)
Methylacetoacetyl-CoAMetabolite15476 (ChEBI)
Methylbutyryl-CoAMetaboliteHMDB0001041 (HMDB)
Methylcrotonyl-CoAMetaboliteHMDB0001493 (HMDB)
Methylglutaconyl-CoAMetaboliteHMDB0001057 (HMDB)
N-FormylkynurenineMetaboliteHMDB0001200 (HMDB)
NADPMetaboliteHMDB0000217 (HMDB)
NorepinephrineMetaboliteHMDB0000216 (HMDB)
OATGeneProductENSG00000065154 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394
ODC1GeneProductENSG00000115758 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402
OGDHGeneProductENSG00000105953 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293
OH-indole acetaldehydeMetabolite50157 (ChEBI)
OH-indoleacetateMetaboliteHMDB0000763 (HMDB)
OH-isobutyrateMetaboliteCHEBI:19641 (ChEBI)
OH-isobutyryl-CoAMetaboliteHMDB0001052 (HMDB)
OH-isovaleryl-CoAMetabolite28291 (ChEBI)
OH-methylglutaryl-CoAMetaboliteHMDB0001375 (HMDB)
OH-phenylpyruvateMetabolite
OTCGeneProductENSG00000036473 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448
OrnithineMetaboliteHMDB0000214 (HMDB)
Ox. glutathioneMetaboliteHMDB0003337 (HMDB)
OxaloacetateMetaboliteHMDB0000223 (HMDB)
OxobutyrateMetaboliteHMDB0000005 (HMDB)
P-enolpyruvateMetaboliteHMDB0000263 (HMDB)
P4HA2GeneProductENSG00000072682 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286
PCGeneProductENSG00000173599 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520
PCK1GeneProductENSG00000124253 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501
PDHA1GeneProductENSG00000131828 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775
PDHXGeneProductENSG00000110435 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627
PDK4GeneProductENSG00000004799 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481
PKMGeneProductENSG00000067225 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591
PNMTGeneProductENSG00000141744 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724
PPM1LGeneProductENSG00000163590 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577
PYCR1GeneProductENSG00000183010 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795
Phe-tRNAMetaboliteCHEBI:29153 (ChEBI)
PhenylalanineMetaboliteHMDB0000159 (HMDB)
ProlineMetaboliteHMDB0000162 (HMDB)
Propionyl-CoAMetaboliteHMDB0001275 (HMDB)
PutrescineMetaboliteHMDB0001414 (HMDB)
PyruvateMetaboliteHMDB0000243 (HMDB)
R-S-glutathioneMetaboliteCHEBI:17021 (ChEBI)
RARSGeneProductENSG00000113643 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297
Red. GlutathioneMetaboliteHMDB0000125 (HMDB)
SDHAGeneProductENSG00000073578 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195
SDSGeneProductENSG00000135094 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270
SMSGeneProductENSG00000102172 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490
SRMGeneProductENSG00000116649 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690
SUCLG1GeneProductENSG00000163541 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234
SerineMetaboliteHMDB0000187 (HMDB)
SerotoninMetaboliteHMDB0000259 (HMDB)
SpermidineMetaboliteHMDB0001257 (HMDB)
SpermineMetaboliteHMDB0001256 (HMDB)
SuccinateMetaboliteHMDB0000254 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
TATGeneProductENSG00000198650 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487
TCA cyclePathway
TDO2GeneProductENSG00000151790 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486
THGeneProductENSG00000180176 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735
TPH1GeneProductENSG00000129167 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796
TPOGeneProductENSG00000115705 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813
ThreonineMetaboliteHMDB0000167 (HMDB)
ThyroxineMetaboliteHMDB0000248 (HMDB)
Tiglyl-CoAMetaboliteHMDB0002054 (HMDB)
Trp-tRNAMetaboliteCHEBI:29159 (ChEBI)
TryptamineMetaboliteHMDB0000303 (HMDB)
TryptophanMetaboliteHMDB0000929 (HMDB)
Tyr-tRNAMetaboliteCHEBI:29161 (ChEBI)
TyrosineMetaboliteHMDB0000158 (HMDB)
UreaMetaboliteHMDB0000294 (HMDB)
VARSGeneProductENSG00000204394 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675
Val-tRNAMetaboliteCHEBI:29164 (ChEBI)
WARSGeneProductENSG00000140105 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630
carbamoyl-PMetaboliteHMDB0001096 (HMDB)
dopaMetabolite
glutamate metabolismPathway
glutamate semialdehydeMetaboliteCHEBI:15757 (ChEBI)
glutamyl-PMetaboliteCHEBI:21314 (ChEBI)
glutamyl-cysteineMetaboliteCHEBI:17515 (ChEBI)
glycolysis & gluconeogenesisPathwayWP157 (WikiPathways)
homogentisateMetaboliteCHEBI:16169 (ChEBI)
hydroxy-prolineMetaboliteHMDB0000725 (HMDB)
indole-pyruvateMetabolite
isobutyryl-CoAMetaboliteCHEBI:15479 (ChEBI)
isocitrateMetaboliteHMDB0000193 (HMDB)
mercaptopyruvateMetaboliteHMDB0001368 (HMDB)
methacrylyl-CoAMetaboliteCHEBI:27754 (ChEBI)
methylhistamineMetaboliteHMDB0000898 (HMDB)
methylmalonate semialdehydeMetaboliteCHEBI:16256 (ChEBI)
methylmalonyl-CoAMetaboliteCHEBI:15465 (ChEBI)
oxo-isocaproateMetaboliteCHEBI:17865 (ChEBI)
oxo-isovalerateMetaboliteCHEBI:11851 (ChEBI)
oxo-methyl-valerate MetaboliteCHEBI:35146 (ChEBI)
phenylpyruvateMetabolite
pyrroline carboxylateMetaboliteHMDB0006875 (HMDB)
pyruvate metabolismPathway
urea cyclePathway
valineMetaboliteHMDB0000883 (HMDB)
vanillyl mandelateMetabolite

Annotated Interactions

No annotated interactions
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