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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Degradation Chemotaxis NO induction FOXO3 CDC42 PREX1 Calcium Phosphatidylinositol-3,4,5-trisphosphate D-myo-Inositol 1,4,5-trisphosphate MAPK signaling pathway PTK2 3',5'-Cyclic AMP DOCK2 PXN Ubiquitin mediated proteolysis Diacylglycerol PAK1 BCAR1 RASGRP2 Leukocyte transendothelial migration PRKCZ ITK Regulation of actin cytoskeleton GRB2 NCF1 Cytokine-cytokine receptor interaction PARD3 PTK2B PRKCZ Jak-STAT signaling pathway ELMO1 MAP2K1 SHC1 SHC3 SHC2 SHC4 mmu:20416 mmu:20418 mmu:216148 mmu:271849 CXCL16 CCL27 CCL22 CCL17 PPBP CCL4 CCL7 CXCL11 CCL15 CX3CL1 PF4 CXCL5 CCL1 CCL11 CXCL9 CXCL14 Ccl8 CCL7 CCL21 XCL1 CXCL12 CXCL3 CXCL10 CCL24 CCL3 CCL15 CCL28 Ccl2 Cxcl15 CCL19 CCL25 CCL19 CCL27 c-C motif chemokine 12-like CXCL13 CCL26 CCL5 CCL21 CXCL3 CCL20 mmu:100039053 mmu:100039863 mmu:100504977 mmu:14825 mmu:15945 mmu:16963 mmu:17329 mmu:18829 mmu:20290 mmu:20292 mmu:20293 mmu:20295 mmu:20296 mmu:20297 mmu:20299 mmu:20300 mmu:20301 mmu:20302 mmu:20303 mmu:20304 mmu:20305 mmu:20306 mmu:20307 mmu:20308 mmu:20309 mmu:20310 mmu:20311 mmu:20312 mmu:20315 mmu:24047 mmu:541307 mmu:55985 mmu:56066 mmu:56221 mmu:56744 mmu:56838 mmu:57266 mmu:57349 mmu:65956 mmu:66102 ROCK1 ROCK2 mmu:19877 mmu:19878 CHUK IKBKB IKBKG mmu:12675 mmu:16150 mmu:16151 Gm12844 Rhoa mmu:11848 mmu:433749 RAP1A RAP1B mmu:109905 mmu:215449 CX3CR1 CCR8 CCR1 CCR3 XCR1 CCR10 CCR7 CCR1 CXCR6 CCR4 CXCR4 CXCR3 CCR2 CCR2 CCR6 CCR9 CXCR2 CXCR5 CXCR2 mmu:12145 mmu:12458 mmu:12765 mmu:12766 mmu:12767 mmu:12768 mmu:12769 mmu:12770 mmu:12771 mmu:12772 mmu:12773 mmu:12774 mmu:12775 mmu:12776 mmu:12777 mmu:13051 mmu:227288 mmu:23832 mmu:80901 GNGT2 GNG4 GNG10 Gm5741 GNB5 GNG5 GNB3 GNG11 GNG2 GNG7 GNB1 Gm4356 GNG12 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like GNG8 GNG5 GNGT1 GNB4 Gm3785 GNG13 GNB2 GNG3 mmu:100042311 mmu:100043318 mmu:100043507 mmu:100503710 mmu:14688 mmu:14693 mmu:14695 mmu:14696 mmu:14697 mmu:14699 mmu:14700 mmu:14701 mmu:14702 mmu:14704 mmu:14706 mmu:14707 mmu:14708 mmu:14709 mmu:14710 mmu:436049 mmu:64337 mmu:66066 WASL WAS mmu:22376 mmu:73178 MAPK1 MAPK3 mmu:26413 mmu:26417 ADCY2 ADCY5 ADCY7 ADCY3 ADCY4 ADCY8 ADCY9 ADCY1 ADCY6 mmu:104110 mmu:104111 mmu:11512 mmu:11513 mmu:11514 mmu:11515 mmu:210044 mmu:224129 mmu:432530 JAK2 JAK3 mmu:16452 mmu:16453 NFKB1 RELA mmu:18033 mmu:19697 GRK2 GRK6 GRK4 GRK1 GRK5 mmu:110355 mmu:14772 mmu:14773 mmu:24013 mmu:26385 SOS1 SOS2 mmu:20662 mmu:20663 AKT2 AKT3 AKT1 mmu:11651 mmu:11652 mmu:23797 ARRB2 ARRB1 mmu:109689 mmu:216869 RAC2 RAC1 mmu:19353 mmu:19354 KRAS HRAS NRAS mmu:15461 mmu:16653 mmu:18176 STAT1 STAT2 STAT5B STAT3 mmu:20846 mmu:20847 mmu:20848 mmu:20851 PLCB4 PLCB3 PLCB2 PLCB1 mmu:18795 mmu:18796 mmu:18797 mmu:18798 CRKL CRK mmu:12928 mmu:12929 NFKBIA NFKBIB mmu:18035 mmu:18036 GNAI2 GNAI3 GNAI1 mmu:14677 mmu:14678 mmu:14679 VAV2 VAV1 VAV3 mmu:22324 mmu:22325 mmu:57257 RAF1 BRAF mmu:109880 mmu:110157 PIK3R1 PIK3R2 PIK3R3 PIK3CB PIK3CD PIK3R5 PIK3CA PIK3CG mmu:18706 mmu:18707 mmu:18708 mmu:18709 mmu:18710 mmu:30955 mmu:320207 mmu:74769 PRKACG PRKACB PRKX mmu:18747 mmu:18749 mmu:19108 TIAM1 TIAM2 mmu:21844 mmu:24001 PRKCB PRKCD mmu:18751 mmu:18753 GSK3B AC006486.9 mmu:56637 mmu:606496 Gm11787 CSK LYN FGR HCK mmu:12988 mmu:14191 mmu:15162 mmu:17096 mmu:666513 ROS production Receptor internalization Migration Chemotaxis Cellular shape changes Metestasis Degranulation ROS production Cytokine production Cellular growth and differentiation Cell survival Migration Apoptosis Name: Chemokine signaling Last Modified: 10/17/2013 Organism: Homo sapiens
Description
Chemokines are small cytokines, or signaling proteins, secreted by cells. A major rol of chemokines is to act as chemoattractants in guiding migration of cells. Chemokine signals are transduced by G-protein coupled receptors, which dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization.
This pathway was adapted from KEGG
Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
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