Leptin and adiponectin (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none beta-oxidationMitochondrionADIPOR1Fatty acidLEPFatty acidADIPOR2ACACAAcetyl-CoALEPRCPT1AADIPOQMalonyl-CoAPRKAA1PRKAB1PRKAG1Name: Leptin and adiponectinOrganism: Homo sapiens


Description

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [Dyck et al.](http://www.ncbi.nlm.nih.gov/pubmed/16497175).


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3934).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Leptin and adiponectin", WP683 revision 71946, with a 100.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Homology Converted

Ontology Terms

Bibliography

  1. Dyck DJ, Heigenhauser GJ, Bruce CR; ''The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity.''; Acta Physiol (Oxf), 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137956
Approved
view20:54, 10 March 2025KhanspersModified description
107151view14:23, 17 September 2019MaintBotChEBI identifier normalization
106628view20:54, 12 September 2019KhanspersModified description
105634view05:05, 10 August 2019KhanspersModified description
90768view01:17, 14 December 2016KhanspersOntology Term : 'glucose metabolism disease' added !
90767view01:16, 14 December 2016KhanspersOntology Term : 'leptin system pathway' added !
90766view01:16, 14 December 2016KhanspersOntology Term : 'adiponectin signaling pathway' added !
90765view01:16, 14 December 2016Khanspersupdated source pathway information
90764view01:15, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACACAGeneProductENSG00000278540 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107476
ADIPOQGeneProductENSG00000181092 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ADIPOR1GeneProductENSG00000159346 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:72674
ADIPOR2GeneProductENSG00000006831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68465
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
CPT1AGeneProductENSG00000110090 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
LEPGeneProductENSG00000174697 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16846
LEPRGeneProductENSG00000116678 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
Malonyl-CoAMetaboliteCHEBI:15531 (ChEBI)
PRKAA1GeneProductENSG00000132356 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:105787
PRKAB1GeneProductENSG00000111725 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19079
PRKAG1GeneProductENSG00000181929 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19082

Annotated Interactions

No annotated interactions
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