Mevalonate pathway (Homo sapiens)

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1MVDGeranyl diphosphateCholesterolAcetyl-CoAAcetoacetyl-CoAUbiquinoneHMGCRPMVKDimethylallyl diphosphateMVK(R)-5-phosphomevalonateHMGCS1HMG-CoAACAT2mevalonateDolichol(R)-5-diphosphomevalonateFDPS


The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones. (Wikipedia)

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  1. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ; ''the interplay between cell signalling and the mevalonate pathway in cancer''; ,


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107557view00:00, 20 October 2019AlexanderPicoModified description
106770view13:25, 17 September 2019MaintBotHMDB identifier normalization
103308view00:19, 22 February 2019AlexanderPicostandard node sizes and less empty space
97112view22:53, 29 April 2018AlexanderPicoReverted to version '01:07, 1 April 2018' by AlexanderPico
97111view22:20, 29 April 2018WpblockedModified title
96733view08:07, 1 April 2018EgonwReplaced another secondary ChEBI identifier with a primary identifier.
96717view13:52, 30 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94743view15:10, 5 October 2017Mkutmonfix unconnected line
91920view04:43, 6 April 2017KhanspersOntology Term : 'isoprenoid metabolic pathway' added !
91361view14:13, 10 February 2017JacobwindsorNew pathway
91351view21:29, 6 February 2017KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
(R)-5-diphosphomevalonateMetaboliteCHEBI:15899 (ChEBI)
(R)-5-phosphomevalonateMetaboliteCHEBI:17436 (ChEBI)
ACAT2GeneProductENSG00000120437 (Ensembl)
Acetoacetyl-CoAMetaboliteCHEBI:15345 (ChEBI)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
CholesterolMetaboliteHMDB0000067 (HMDB)
Dimethylallyl diphosphateMetaboliteCHEBI:16057 (ChEBI)
DolicholMetaboliteCHEBI:88766 (ChEBI)
FDPSGeneProductENSG00000160752 (Ensembl)
Geranyl diphosphateMetaboliteCHEBI:17211 (ChEBI)
HMG-CoAMetaboliteCHEBI:15467 (ChEBI)
HMGCRGeneProductENSG00000113161 (Ensembl)
HMGCS1GeneProductENSG00000112972 (Ensembl)
MVDGeneProductENSG00000167508 (Ensembl)
MVKGeneProductENSG00000110921 (Ensembl)
PMVKGeneProductENSG00000163344 (Ensembl)
UbiquinoneMetaboliteCHEBI:16389 (ChEBI)
mevalonateMetaboliteQ27109878 (Wikidata)

Annotated Interactions

No annotated interactions

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