Protein alkylation leading to liver fibrosis (Homo sapiens)
From WikiPathways
Description
Protein alkylation leading to liver fibrosis
This pathway is based on descriptive text of the adverse outcome pathway (AOP) on https://aopwiki.org/aops/38
Quality Tags
Ontology Terms
Bibliography
- Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M; ''Adverse outcome pathway development from protein alkylation to liver fibrosis.''; Arch Toxicol, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Apoptosis Modulation and Signaling | Pathway | WP1772 (WikiPathways) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
CCl4 | Metabolite | CHEBI:27385 (ChEBI) | |
Collagen biosynthesis and modifying enzymes | Pathway | WP2725 (WikiPathways) | |
Dimethylnitrosamine | Metabolite | CHEBI:35807 (ChEBI) | |
KE134: Increased activation and recruitment of Kupffer Cells | Event | 134 (AOP-Wiki KE) | |
KE244: Protein alkylation | Event | 244 (AOP-Wiki KE) | |
KE265: Stellate cell activation | Event | 265 (AOP-Wiki KE) | |
KE276: TGFbeta1 expression up regulation | Event | 276 (AOP-Wiki KE) | |
KE344: Liver Fibrosis | Event | 344 (AOP-Wiki KE) | |
KE55: Cell injury/death | Event | 55 (AOP-Wiki KE) | |
KE68: Collagen accumulation | Event | 68 (AOP-Wiki KE) | |
TGF-beta signaling pathway | Pathway | WP366 (WikiPathways) | |
TNF alpha Signaline Pathway | Pathway | WP231 (WikiPathways) | |
allyl alcohol | Metabolite | CHEBI:16605 (ChEBI) | |
retinol | Metabolite | CHEBI:50211 (ChEBI) | |
thioacetamide | Metabolite | Q416253 (Wikidata) |
Annotated Interactions
No annotated interactions