By summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated together to generate a whole sight in early mouse development centered around Ptf1a, although there are some hypothetical relationships and the distinct development of dorsal and ventral pancreas in very early stage is neglected.
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway WP201 (rev 69113) with a 81.0% conversion rate.
Masui, T, Long, Q, Beres, T M, Magnuson, M A, MacDonald, R J; ''Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex''; Genes Dev, 2007 PubMedEurope PMCScholia
Miyatsuka, T, Matsuoka, T A, Shiraiwa, T, Yamamoto, T, Kojima, I, Kaneto, H; ''Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III''; Biochem Biophys Res Commun, 2007 PubMedEurope PMCScholia
Rodolosse, A, Campos, M L, Rooman, I, Lichtenstein, M, Real, F X; ''P/CAF modulates the activity of the transcription factor p48/PTF1a involved in pancreatic acinar differentiation''; Biochem J, 2008 PubMedEurope PMCScholia
Junfeng Wang, Gamze Kilic, Muge Aydin, Zoe Burke, Guillermo Oliver, Beatriz Sosa-Pineda; ''Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells''; Developmental Biology, 2005 PubMedEurope PMCScholia
Jacquemin, P, Yoshitomi, H, Kashima, Y, Rousseau, G G, Lemaigre, F P, Zaret, K S; ''An endothelial-mesenchymal relay pathway regulates early phases of pancreas development''; Dev Biol, 2006 PubMedEurope PMCScholia
Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI; ''Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)''; J Histochem Cytochem, 1998 PubMedEurope PMCScholia
Wells, J M, Esni, F, Boivin, G P, Aronow, B J, Stuart, W, Combs, C, Sklenka, A, Leach, S D, Lowy, A M; ''Wnt/beta-catenin signaling is required for development of the exocrine pancreas''; BMC Dev Biol, 2007 PubMedEurope PMCScholia
Fujikura, J, Hosoda, K, Kawaguchi, Y, Noguchi, M, Iwakura, H, Odori, S, Mori, E, Tomita, T, Hirata, M, Ebihara, K, Masuzaki, H, Fukuda, A, Furuyama, K, Tanigaki, K, Yabe, D, Nakao, K; ''Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development''; Dev Dyn, 2007 PubMedEurope PMCScholia
Ghosh, B, Leach, S D; ''Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex''; Biochem J, 2006 PubMedEurope PMCScholia
Dong, P D, Provost, E, Leach, S D, Stainier, D Y; ''Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas''; Genes Dev, 2008 PubMedEurope PMCScholia
Wiebe, P O, Kormish, J D, Roper, V T, Fujitani, Y, Alston, N I, Zaret, K S, Wright, C V, Stein, R W, Gannon, M; ''Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression''; Mol Cell Biol, 2007 PubMedEurope PMCScholia
Watada H, Mirmira RG, Leung J, German MS; ''Transcriptional and Translational Regulation of -Cell Differentiation Factor Nkx6.1''; J Biol Chem, 2000 PubMedEurope PMCScholia
Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
Ontology Terms
Bibliography
History
External references
DataNodes
Annotated Interactions
No annotated interactions