Vitamins A and D - action mechanisms (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Retinoic acidGutVDREEffector cellSkinLiverKidneyVitamin Drich dietBeta-caroteneUV-B light7-DehydrocholesterolRetinol (vit A)RetinalATRA9-cis-Retinoic acid25(OH)D3VDRRXRVitamin D3Previtamin D31,25(OH)2D325(OH)D31,25(OH)2D3NucleusRXRRXRRARERARRXRNucleusEffector cellVitamin Drich dietName: Vitamins A and D - action mechanismsOrganism: Homo sapiens


Description

The active forms of vitamins A and D both activate nuclear receptors. The generation of the vitamin metabolites and their role in the activation of the nuclear receptors is shown in the pathway.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : flavonoid biosynthetic pathway
 

Bibliography

  1. Mora JR, Iwata M, von Andrian UH; ''Vitamin effects on the immune system: vitamins A and D take centre stage.''; Nat Rev Immunol, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
136783
Approved
view00:52, 21 February 2025EweitzRefine node graphics
136782view00:49, 21 February 2025EweitzUpgrade custom nodes
136781view00:39, 21 February 2025EweitzEconomize layout
136780view00:36, 21 February 2025EweitzEconomize layout
134805view03:03, 27 July 2024EweitzStandardize case
134802view02:59, 27 July 2024EweitzOntology Term : 'kidney cell' added !
134801view02:59, 27 July 2024EweitzOntology Term : 'hepatocyte' added !
106136view12:03, 16 August 2019MaintBotHMDB identifier normalization
98582view17:56, 17 September 2018AlexanderPicoupdated outdated chebi
98552view18:06, 16 September 2018AlexanderPicoupdated outdated chebi
98548view21:29, 14 September 2018Khanspersconverted interaction to graphical line
98503view09:22, 13 September 2018SusanModified description
98502view09:18, 13 September 2018SusanAdd literature
98501view09:08, 13 September 2018SusanOntology Term : 'vitamin D metabolic pathway' added !
98500view09:07, 13 September 2018SusanOntology Term : 'vitamin D signaling pathway' added !
98499view09:07, 13 September 2018SusanOntology Term : 'vitamin A and metabolites signaling pathway' added !
98498view09:04, 13 September 2018SusanNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
1,25(OH)2D3MetaboliteHMDB0000969 (HMDB)
25(OH)D3MetaboliteCHEBI:17933 (ChEBI)
7-DehydrocholesterolMetaboliteHMDB0000032 (HMDB)
9-cis-Retinoic acidMetaboliteHMDB0002369 (HMDB)
ATRAMetaboliteCHEBI:50648 (ChEBI)
Beta-caroteneMetaboliteCHEBI:17579 (ChEBI)
Previtamin D3MetaboliteHMDB0006500 (HMDB)
RARGeneProductENSG00000131759 (Ensembl)
RXRGeneProductENSG00000131759 (Ensembl)
RXRGeneProductENSG00000186350 (Ensembl)
RetinalMetaboliteCHEBI:15035 (ChEBI)
Retinol (vit A)MetaboliteCHEBI:17336 (ChEBI)
UV-B lightQ22914692 (Wikidata)
VDRGeneProductENSG00000111424 (Ensembl)
Vitamin D rich diet
Vitamin D3MetaboliteCHEBI:28940 (ChEBI)

Annotated Interactions

No annotated interactions

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