FABP4 in ovarian cancer (Homo sapiens)
From WikiPathways
Description
Regulation of FABP4 in ovarian cancer. FABP4 (fatty acid binding protein) can substantially increase metastatic potential of ovarian cancer cells, and leads to more aggressive disease. Mir-409-3p negatively regulates FABP4 in ovarian cancer cells, and mir-409-3p is decreased in hypoxic conditions. Pink arrows indicates potential therapuetic therapeutic stratgeies; in Gharpure et al, DOPC nanoliposomes containing either miR-409-3p mimic or FABP4 siRNA was shown to inhibit tumor progression.
Description was adapted from Gharpure et al.
Quality Tags
 | Approved version |
 |  |
Ontology Terms
Saving...Pathway Ontology : hypertrophic cardiomyopathy pathway
Bibliography
- Gharpure KM, Pradeep S, Sans M, Rupaimoole R, Ivan C, Wu SY, Bayraktar E, Nagaraja AS, Mangala LS, Zhang X, Haemmerle M, Hu W, Rodriguez-Aguayo C, McGuire M, Mak CSL, Chen X, Tran MA, Villar-Prados A, Pena GA, Kondetimmanahalli R, Nini R, Koppula P, Ram P, Liu J, Lopez-Berestein G, Baggerly K, S Eberlin L, Sood AK; ''FABP4 as a key determinant of metastatic potential of ovarian cancer.''; Nat Commun, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
Name  | Type | Database reference | Comment |
|---|---|---|---|
| FABP4 | GeneProduct | ENSG00000170323 (Ensembl)  | |
| Hypoxia | Q105688 (Wikidata) | ||
| MIR409 | Rna | ENSG00000199107 (Ensembl) |
Annotated Interactions
No annotated interactions
