Hippo-YAP signaling (Homo sapiens)
From WikiPathways
Description
When the Hippo-YAP pathway is in the "ON" state, YAP and TAZ are phosphorylated and held in cytoplasm. When the pathway is in the "OFF" state, unphosphorylated YAP and TAZ accumulate in the nucleus with TEAD.
This pathway was created based on figure 1 from Zhou et al.
Phosphorylatin sites were added based on information from PhosphoSitePlus, www.phosphosite.org.Quality Tags
Ontology Terms
Saving...Bibliography
- Zhou W, Zhao M; ''How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases.''; J Immunol Res, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 14-3-3 | Protein | PF00244 (Pfam)  | |
| CXCL10 | GeneProduct | 3627 (Entrez Gene) | MOB1 |
| LATS1 | GeneProduct | 9113 (Entrez Gene) | LATS1/2 |
| LATS2 | GeneProduct | 26524 (Entrez Gene) | LATS1/2 |
| MAP4K1 | GeneProduct | ENSG00000104814 (Ensembl) | |
| MAP4K2 | GeneProduct | ENSG00000168067 (Ensembl) | |
| MAP4K3 | GeneProduct | ENSG00000011566 (Ensembl) | |
| MAP4K4 | GeneProduct | ENSG00000071054 (Ensembl) | |
| MINK1 | GeneProduct | ENSG00000141503 (Ensembl) | |
| NDRG1 | GeneProduct | 10397 (Entrez Gene) | NDR1/2 |
| NF2 | GeneProduct | 4771 (Entrez Gene) | Nf2 |
| RASSF1 | GeneProduct | ENSG00000068028 (Ensembl) | |
| SAV1 | GeneProduct | 60485 (Entrez Gene) | SAV1 |
| STK3 | GeneProduct | 6788 (Entrez Gene) | MST1/2 |
| STK38L | GeneProduct | 23012 (Entrez Gene) | NDR1/2 |
| STK4 | GeneProduct | 4485 (Entrez Gene) | MST1/2 |
| TEAD1 | GeneProduct | ENSG00000187079 (Ensembl) | |
| TEAD2 | GeneProduct | ENSG00000074219 (Ensembl) | |
| TEAD3 | GeneProduct | ENSG00000007866 (Ensembl) | |
| TEAD4 | GeneProduct | ENSG00000197905 (Ensembl) | |
| TNIK | GeneProduct | ENSG00000154310 (Ensembl) | |
| WWTR1 | GeneProduct | 25937 (Entrez Gene) | YAP/TAZ |
| YAP1 | GeneProduct | 10413 (Entrez Gene) | YAP/TAZ |
Annotated Interactions
No annotated interactions
