Small cell lung cancer (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Legend+ProliferationActivating mutationG1/S progressionInhibition of apoptosisCell cycleRimiducidCASP8Retinoic acidFHITBIDRXRARARBRXRBRXRG+MYCMAXCKS1BCKS2VenetoclaxOblimersenObatoclaxDNA damageTP53p53 signalingpathwayCDKN1ABAXDDB2POLKBAK1GADD45GGADD45AGADD45B+BCL2BAXCYCSAPAF1CASP3CASP9CYCSCCNE1CCNE2CDK2CDK6CDK4CCND1PRB1E2F1E2F2E2F3SKP1CDKN1CCDKN1BCDKN2BZBTB17LAMA1COL4A4LAMA2LAMA5LAMB1LAMC3LAMB2LAMA3COL4A2LAMA4LAMB3COL4A5COL4A6LAMC1FN1LAMC2COL4A1COL4A3LAMB4ITGB1ITGA6ITGA2ITGA2BITGA3ITGAVPIK3R1PIK3R3PIK3R2PIK3CAPIK3CBPIK3CDPIP3PTK2PTENAKT2AKT1AKT3IKBKGPIKBKBCHUKNFKB1RELANFKBIANFKBIBNFKB1RELAPPNFKBIANFKBIBUbiquitin-mediated proteolysisCCND1BIRC2BIRC3BIRC7BIRC8BCL2L1TRAF2TRAF3TRAF4TRAF5TRAF6TRAF1PTGS2NOS2Inactivating mutation or loss of heterozygosityAmplificationInterrupted control of cell growth, leading to tumor progressionUncontrolled proliferationIncreased survivalGenomic instabilityAngiogenesisResistance to apoptotic signalsName: Small cell lung cancerOrganism: Homo sapiens


Description

Small cell lung carcinoma (SCLC) is a highly malignant cancer of the lung.

Genes altered in small cell lung carcinoma: 1. TP53 is mutated in 70-90% of SCLCs. 2. RB1 is inactivated in most SCLCs. 3. PTEN is mutated in 2-10% of SCLCs. 4. MYC amplifications and amplification of MYC family members is found in 30% of SCLCs. 5. FHIT protein expression is lost due to loss of heterozygocity (LOH) on chromosome arm 3p found in more than 80% of SCLCs.

This description was adapted from [Wikipedia](https://en.wikipedia.org/wiki/Small-cell_carcinoma).

Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
  2. ''KEGG small cell lung cancer''; https://www.kegg.jp/dbget-bin/www_bget?pathway+map05222,
  3. Deng WG, Nishizaki M, Fang B, Roth JA, Ji L; ''Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.''; Biochem Biophys Res Commun, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138081
Approved
view23:56, 13 March 2025EweitzModified description
138080view23:56, 13 March 2025EweitzModified description
138078view21:56, 13 March 2025EweitzRefine state position
138077view21:55, 13 March 2025EweitzRefine state positions
138065view12:30, 13 March 2025EweitzOntology Term : 'lung small cell carcinoma' added !
138063view12:27, 13 March 2025EweitzClear dimension cache
138062view12:26, 13 March 2025EweitzEconomize layout
138061view12:25, 13 March 2025EweitzEconomize layout
137451view13:03, 2 March 2025EweitzFix padding in nucleus, refine layering
137450view12:55, 2 March 2025EweitzFix truncated text
137449view12:48, 2 March 2025EweitzRefine state positions
137442view12:42, 2 March 2025EweitzEconomize layout
137441view12:39, 2 March 2025EweitzEconomize layout
137437view12:35, 2 March 2025EweitzEconomize layout
137411view01:58, 2 March 2025EweitzEconomize layout
137410view01:53, 2 March 2025EweitzEconomize layout, fix truncated text
137409view01:42, 2 March 2025EweitzEconomize layout
137408view01:37, 2 March 2025EweitzEconomize layout
137407view01:33, 2 March 2025EweitzEconomize layout
137406view01:30, 2 March 2025EweitzStack grouped nodes
137405view01:26, 2 March 2025EweitzTailor node height
137151view23:22, 27 February 2025KhanspersModified description
135693view00:31, 27 October 2024EweitzStandardize case
135692view00:29, 27 October 2024EweitzEconomize layout
127394view19:35, 29 September 2023Khanspersupdated phosphosites
127235view20:16, 25 August 2023Khanspersadded lit ref and updated description
124606
CPTAC
view19:35, 15 November 2022EgonwReplaced an old Wikidata identifier
123497view04:56, 29 July 2022EgonwMade a pathway clickable
119261view07:45, 23 June 2021Finterlyadded KEGG biopax information
108148view10:35, 29 November 2019FehrhartOntology Term : 'lung cancer' added !
108147view10:35, 29 November 2019FehrhartOntology Term : 'cancer' added !
108146view10:35, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106808view13:28, 17 September 2019MaintBotHMDB identifier normalization
105318view00:01, 30 July 2019Khanspersupdated labels
105188view22:30, 17 July 2019Khanspersminor update to DNA Damage Response
105187view22:09, 17 July 2019Khanspersupdated NFKB activation, interrupted effects
105186view22:02, 17 July 2019Khanspersfixed legend and added FHIT info
105185view21:55, 17 July 2019Khanspersupdated interrupted interactions, legend
105184view21:33, 17 July 2019KhanspersModified description
105183view21:27, 17 July 2019Khanspersadded phosphosites etc
105153view21:29, 12 July 2019Khanspersexpanded FHIT information
105033view03:24, 2 July 2019Khansperswork in progress
105032view03:01, 2 July 2019KhanspersModified description
105031view03:00, 2 July 2019KhanspersModified description
104975view16:15, 27 June 2019KhanspersOntology Term : 'signaling pathway' added !
104974view16:15, 27 June 2019KhanspersOntology Term : 'small cell lung carcinoma pathway' added !
104973view16:14, 27 June 2019KhanspersModified title
104972view16:13, 27 June 2019KhanspersNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
APAF1GeneProductENSG00000120868 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BIRC2GeneProductENSG00000110330 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC7GeneProductENSG00000101197 (Ensembl)
BIRC8GeneProductENSG00000163098 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl) CCNE1; cyclin E
CCNE2GeneProductENSG00000175305 (Ensembl) CCNE2; cyclin E
CDK2GeneProductENSG00000123374 (Ensembl) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProductENSG00000135446 (Ensembl) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProductENSG00000105810 (Ensembl) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN1CGeneProductENSG00000129757 (Ensembl) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2BGeneProductENSG00000147883 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CKS1BGeneProductENSG00000173207 (Ensembl)
CKS2GeneProductENSG00000123975 (Ensembl)
COL4A1GeneProduct1282 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
COL4A3GeneProductENSG00000169031 (Ensembl)
COL4A4GeneProduct1286 (Entrez Gene)
COL4A5GeneProductENSG00000188153 (Ensembl)
COL4A6GeneProduct1288 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
Cell cyclePathway
DDB2GeneProductENSG00000134574 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl) E2F1; E2F transcription factor 1
E2F2GeneProductENSG00000007968 (Ensembl) E2F2; E2F transcription factor 2
E2F3GeneProductENSG00000112242 (Ensembl) E2F3; E2F transcription factor 3
FHITGeneProductENSG00000189283 (Ensembl)
FN1GeneProduct2335 (Entrez Gene)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
ITGA2GeneProduct3673 (Entrez Gene)
ITGA2BGeneProduct3674 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMB4GeneProductENSG00000091128 (Ensembl)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
MAXGeneProductENSG00000125952 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
ObatoclaxMetaboliteQ7074645 (Wikidata)
OblimersenMetaboliteQ7075165 (Wikidata)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteHMDB0004249 (HMDB)
POLKGeneProductENSG00000122008 (Ensembl)
PTENGeneProduct5728 (Entrez Gene)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
RARBGeneProductENSG00000077092 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
Retinoic acidMetaboliteCHEBI:6067 (ChEBI)
RimiducidMetaboliteQ27279658 (Wikidata)
SKP1GeneProductENSG00000113558 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF1GeneProductENSG00000056558 (Ensembl)
TRAF2GeneProductENSG00000127191 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF4GeneProductENSG00000076604 (Ensembl)
TRAF5GeneProductENSG00000082512 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
VenetoclaxMetaboliteCHEBI:133021 (ChEBI)
ZBTB17GeneProductENSG00000116809 (Ensembl)
p53 signaling pathwayPathway

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4658"
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