SARS coronavirus and innate immunity (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IFN-alpha groupIFNA21IFNA10IFNA17IFNA13IFNA6IFNA16IFNA2IFNA7IFNA8IFNA1IFNA14IFNA4IFNA5NucleusEndocytosisPhosphorylated proteinISRE response elementDNACellSSTAT1STAT2IRF9IKBKETBK1TRAF3IFNAR2TYK2IFNAR1JAK1IFIH1DDX58MAVSIFNB1IFN-betaIRF3TLR3SACE2TICAM1IRF3IRF3IRF3ACE2SSARS virus protein (Spike)STAT1STAT2IRF9IFN-betaresponse elementMitochondriaVesicleSARS virus (with RNA)LegendPPPPPName: SARS coronavirus and innate immunityOrganism: Homo sapiens


Description

SARS-CoV triggers the hosts innate immune system via the type I interferon system in dendritic cells and macrophages, which activate ISRE and IFN-b sentitive promoter elements.

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Featured.pngCurrent Highlight
Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: COVID-19
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Spiegel M, Pichlmair A, Martínez-Sobrido L, Cros J, García-Sastre A, Haller O, Weber F; ''Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.''; J Virol, 2005 PubMed Europe PMC Scholia
  2. Frieman M, Heise M, Baric R; ''SARS coronavirus and innate immunity.''; Virus Res, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134670
Approved
view15:14, 25 July 2024Ash iyeradded P in phosphorhylation
134643view12:11, 23 July 2024EweitzRefine legend, label placements
134642view12:09, 23 July 2024EweitzFix label occlusion, standardize case
134641view12:07, 23 July 2024EweitzOntology Term : 'Coronavirus infectious disease' added !
134619view10:50, 23 July 2024EweitzRefine legend
134618view10:46, 23 July 2024EweitzCorrect term: phosphorylized -> phosphorylated
134617view10:41, 23 July 2024EweitzEconomize layout
124650
COVID
view13:12, 18 November 2022JfigueirahasbunUpdated viral protein shape and identifier
115852view15:35, 18 March 2021L DupuisAdded literature reference to interaction from IRF3 to IFN-beta Response Element
113956view09:30, 11 December 2020EgonwType response elements as GeneProduct
113632view11:32, 8 November 2020EgonwConverted three interacting Labels to DataNodes.
110359view17:32, 7 May 2020Fehrhartgraphical improvements
110248view06:52, 30 April 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
110247view06:52, 30 April 2020FehrhartOntology Term : 'viral infectious disease' added !
110246view06:52, 30 April 2020FehrhartOntology Term : 'type I interferon signaling pathway' added !
110239view15:24, 29 April 2020FehrhartNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACE2GeneProductENSG00000130234 (Ensembl)
DDX58GeneProductENSG00000107201 (Ensembl) RIG-I
EndocytosisPathway
IFIH1GeneProductENSG00000115267 (Ensembl) MDA5
IFN-beta response elementGeneProduct
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNAR1GeneProduct3454 (Entrez Gene)
IFNAR2GeneProduct3455 (Entrez Gene)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl) IKK-e
IRF3GeneProductENSG00000126456 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
ISRE response elementGeneProduct
JAK1GeneProductENSG00000162434 (Ensembl)
MAVSGeneProductENSG00000088888 (Ensembl)
SProteinP0DTC2 (Uniprot-TrEMBL)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
TICAM1GeneProduct148022 (Entrez Gene) TRIF
TLR3GeneProductENSG00000164342 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)

Annotated Interactions

No annotated interactions

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