Cellular proteostasis (Homo sapiens)
From WikiPathways
Description
In order to maintain protein homeostasis and cell function, cells are constantly synthesizing as well as degrading proteins. This is especially important when proteins are misfolded, due to extra- or intracellular stress or a genetic mutation, as this is the basis for many diseases. This pathway shows the major events which are involved in proteostasis.
Quality Tags
 | Approved version |
 |  |
Ontology Terms
Saving...Bibliography
- Klaips CL, Jayaraj GG, Hartl FU; ''Pathways of cellular proteostasis in aging and disease.''; J Cell Biol, 2018 PubMed Europe PMC Scholia
- Sahlan M, Zako T, Yohda M; ''Prefoldin, a jellyfish-like molecular chaperone: functional cooperation with a group II chaperonin and beyond.''; Biophys Rev, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
Name  | Type | Database reference | Comment |
|---|---|---|---|
| CHIP | GeneProduct | ENST00000565813.1 (Ensembl)  | |
| Degradation via UPS | Pathway | WP183 (WikiPathways) | |
| Degradation via autophagy | Pathway | WP4923 (WikiPathways) | |
| Hsp110 | GeneProduct | ENST00000629751 (Ensembl) | |
| Hsp40 | GeneProduct | ENSG00000213946 (Ensembl) | |
| Hsp70 | GeneProduct | ENSG00000225217 (Ensembl) | |
| Hsp90 | GeneProduct | ENSG00000224411 (Ensembl) | |
| PFDN1 | GeneProduct | ENSG00000113068 (Ensembl) | |
| PFDN2 | GeneProduct | ENSG00000143256 (Ensembl) | |
| PFDN3 | GeneProduct | ENSG00000155959 (Ensembl) | |
| PFDN4 | GeneProduct | ENSG00000101132 (Ensembl) | |
| PFDN5 | GeneProduct | ENSG00000123349 (Ensembl) | |
| PFDN6 | GeneProduct | ENSG00000204220 (Ensembl) | |
| UPR | Pathway | WP1939 (WikiPathways) |
Annotated Interactions
No annotated interactions
