Mitochondrial complex II assembly (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IMMatrixComplex IIFADSDHAF1SDHDSDHCSDHAF2SDHASDHAF4SDHASDHBSDHAF3SDHAF1SDHAIMSSDHAF2SDHAF4SDHBSDHAF3SDHAF1SDHBSDHAF1SDHAF3SDHAF4SDHDSDHBSDHCSDHAName: Mitochondrial complex II assemblyOrganism: Homo sapiens


Description

Complex II or succinate dehydrogenase (quinone) is shared between the TCA cycle and the ETC. It has no proton pumping activity. It is composed of four subunits encoded by nDNA. Two subunits are hydrophillic, SDHA and SDHB, and two subunits are hydrophobic: SDHC and SDHD. Complex II assembly occurs through the independent maturation of these subunits mediated by subunit-specific chaperones.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : Notch signaling pathway
 

Bibliography

  1. Signes A, Fernandez-Vizarra E; ''Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.''; Essays Biochem, 2018 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117791
Approved
view14:07, 22 May 2021EweitzModified title
110413view10:18, 9 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110387view16:03, 8 May 2020AnnabayaModified description
110376view15:24, 8 May 2020AnnabayaOntology Term : 'electron transport chain pathway' added !
110375view15:24, 8 May 2020AnnabayaOntology Term : 'oxidative phosphorylation pathway' added !
110354view13:39, 7 May 2020AnnabayaNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
FADMetaboliteCHEBI:16238 (ChEBI)
SDHAGeneProductENSG00000073578 (Ensembl)
SDHAF1GeneProductENSG00000205138 (Ensembl)
SDHAF2GeneProductENSG00000167985 (Ensembl)
SDHAF3GeneProductENSG00000196636 (Ensembl)
SDHAF4GeneProductENSG00000154079 (Ensembl)
SDHBGeneProductENSG00000117118 (Ensembl)
SDHCGeneProductENSG00000143252 (Ensembl)
SDHDGeneProductENSG00000204370 (Ensembl)

Annotated Interactions

No annotated interactions

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