Mitochondrial complex I inhibition leading to parkinsonian motor deficits (Homo sapiens)
From WikiPathways
Description
This pathway is a meta-pathway that represents an updated version of the Adverse Outcome Pathway (AOP) of Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits AOP-Wiki:3. All Key Events are present as Key Event nodes, with their corresponding molecular pathways as pathway nodes.
Quality Tags
Ontology Terms
Bibliography
- Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH, Leist M, Schildknecht S; ''An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.''; Arch Toxicol, 2018 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Assembly of mitochondrial complex I | Pathway | WP4324 (WikiPathways) | |
Decreased mitochondrial oxidative phosphorylation | Pathway | WP111 (WikiPathways) | |
Degeneration of DA neurons of nigrostratial pathway | Pathway | WP2855 (WikiPathways) | |
Impaired proteostasis | Pathway | WP4918 (WikiPathways) | |
KE177: N/A, Mitochondrial dysfunction 1 | Event | 177 (AOP-Wiki KE) | |
KE188: N/A, Neuroinflammation | Event | 188 (AOP-Wiki KE) | |
KE887: Inhibition, NADH-ubiquinone oxidoreductase (complex I) | Event | 887 (AOP-Wiki KE) | |
KE888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) | Event | 888 (AOP-Wiki KE) | |
KE889: Impaired, Proteostasis | Event | 889 (AOP-Wiki KE) | |
KE890: Degeneration of dopaminergic neurons of the nigrostriatal pathway | Event | 890 (AOP-Wiki KE) | |
KE896: Parkinsonian motor deficits | Event | 896 (AOP-Wiki KE) | |
MMP+ | Event | 222 (AOP-Wiki Stressor) | |
Neuroinflammation | Pathway | WP4919 (WikiPathways) | |
Parkinsonian motor deficits | Pathway | WP2371 (WikiPathways) | |
Rotenone | Event | 50 (AOP-Wiki Stressor) | |
Unfolded Protein Response | Pathway | WP4925 (WikiPathways) |
Annotated Interactions
No annotated interactions