Opioid receptor pathways (Homo sapiens)
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Calcium influx
PIK3CG
3
OPRM1
2
RELA
Long-term
redox-sensitive
signaling events
in rats
PLD2
2
ARF6
dependent
NADH/NADPH
oxidase
dependent
Extracellular
matrix
Inflammasome
Endosome
Nucleus
PM
PI3K
dependent
OPRD1
MAP2K1
KRAS
T340
RAF1
Y340
Y341
Shift from GPCR to
RTK signaling
SRC
Y416
OPRK1
OPRM1
OPRL1
Amileorate endothelial
dysfunction in
hyperlipidemic rats
AKT1
S473
NOS2
NOS3
S1177
PLD2
ARF-GTP
dependent
CY
PM
CY
OPRM1
2
OPRD1
OPRD1
PRKCE
OPRK1
PPP3CA
FKBP1A
SLC6A3
FOS
ELK1
5
S383
MAPK1
MAPK3
Gi/G0, PI3K
and
SOS dependent
Receptor
desensitization
and anti-opioid
effect
OPRD1
OPRM1
Regulation of
dopamine
signaling
MAPK1
Y187
T185
MAPK3
Y204
T202
OPRM1
Synergistic
antinociceptive
activity
OPRL1
AKT1
S473
GRK3-Arrestin2
and Src dependent
CY
PM
MAPK1
T185
Y187
MAPK3
T202
Y204
GRK2
dependent
OPRD1
OPRM1
Gi/Go
and PI3K
dependent
PI3K and
FRAP/mTOR
dependent
GSK3B
S9
RPS6KB1
T389
T421
S424
Desensitization
and
tolerance
development
Regulation of neuronal
development,
long term memory
and synaptic plasticity
EIF4EBP1
EIF4EBP2
Gi/Go,PI3K
and FRAP/RAFT
dependent
RPS6KB1
MAPK1
MAPK3
Mitogenesis
PI3K
independent
TNF
Reduced apoptosis
of cardiomyocyte in
I/R model of rat
and mouse
MTOR
S2448
Normal bone
homeostasis
mice hypothalamic
arcuate nucleus
neurons
GPX1
CASP3
Receptor
Protein up-regulation
Protein Activation
mRNA up-regulation
Phosphorylation site and residue
Ligand
Inhibition
Transport
Positive regulation of gene expression
Leads to through unknown mechanism
Negative regulation of gene expression
Translocation
Protein-protein interaction
LEGEND
Phosphorylation
Nucleus
Cytoplasm
Plasma membrane
CY
PM
NU
P
DNA
Protein down-regulation
mRNA down-regulation
DNA binding
TLR4
ADCY5
OPRM1
ADCY6
Gi/G0
dependent
SRC
T416
MAPK1
Y187
T185
MAPK3
Y204
T202
MEK
dependent
PRKCZ
T410
Regulation of
glucose
homeostasis
MAPK8
T183
MAPK8
T183
Gi/G0-PI3K
dependent
SOS
mediated
RAC1
CDC42
OPRD1
S363
Adenylyl
cyclase
CY
PM
Desensitization
and
opioid tolerance
SOD1
Neuroprotection
from
hypoxic injury
in I/R rat brain
G-alpha16
mediated
G-beta
gamma
dependent
PLCB3
Desensitization
and
opioid tolerance
Anti
nociception
G beta gamma
dependent
PTK2
Y397
SRC
Y416
PTK2
Y397
SRC
Y416
MAPK14
Y182
T180
AP1-NFAT
mediated
IL4
PLD2
dependent
EEA1
PDGFRB
Y716
KDR
Y1212
Angiogenesis
mouse retinal
endothelial cells
CDK5R1
CDK5
STAT3
S727
Neuroprotection/
Neuronal survival
Reduced PARP
cleavage
beta-arrestin
dependent
MAPK1
Y187
T185
MAPK3
Y204
T202
RPS6KA1
S363
T359
Opiate analgesia
and
tolerance
PKC
dependent
CY
PM
GNAI2
S44
S303
S144
PDK1
Y373
Y376
PRKCZ
PRKCZ
T410
PRKCZ
CCR5
CCR5
S349
Role in
inflammatory
response
MBP
MAPK9
Oligodendrocyte
differentiation
Hematopoietic
stem cell
proliferation
and
differentiation
in cord blood
hematopoietic
stem cells
CY
PM
OPRK1
ARR3
Analgesia
OPRK1
OPRK1
RGS9
Analgesic
response in
mouse D2-type
neurons
MAPK14
CY
PM
ARRB2
Ca2+/Calmodulin
and PKC
dependent
Desensitization
and
opioid tolerance
CREB1
S133
SLC9A1
PKC
dependent
G beta gamma
and PLC
dependent
PKC and Ras
dependent
MAPK1
T185
Y187
MAPK3
T202
Y204
PTK2B
Mitogenesis
FTH1
Downregulates
CXCR4-based
chemotaxis in
rat cortical
neurons
PI3K
dependent
IGF1R
Y1136
Y1135
GSK3B
S9
AKT1
T308
S473
Neuro-
protective
effect in
rat nuclear
accumbens
RGS4
Opiate tolerance,
dependance
and withdrawal
in rat prefrontal
cortex
PRKCE
dependent
STAT3
S727
MCL1
Survival of
mesenchymal
stem cells derieved from
bone marrow of rat
RGS4
OPRM1
GNAO1
Inhibition of
thermal
allodynia
OPRM1
Src and
PKC
dependent
Immuno-
modulation
in human
T-lymphocytes
BDNF
Microglial
activation in
mouse EOC2
cells
BCL2
BAX
FAS
FASLG
Apoptosis in
human
promyelocytic
cells
GRK2
GRK3
CY
PM
Receptor
desensitization
GATA4
NKX2-5
PDYN
Cardiac
differentiation
in embryonic stem
cells
PKC
dependent
ARRB2
ARRB1
CD14
ADCY1
ADCY8
CREB1
S133
GRIN1
S890
GRIN2A
Y1325
CAMK2A