Overview of proinflammatory and profibrotic mediators (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Colony stimulating factorsShared IL-2β chain (CD122)Type I IFNIL-1C chemokine/receptor familyCX3C chemokine/receptor familyCC chemokine/receptor familyType III IFNIL-17Common γ chain receptor ligandsAdaptive immunityCXC chemokine/receptor familyCytokinesTNFαShared receptorsType II IFNCommon β chain (CD131) receptor ligandsIL4IFNGIFNB1SPP1IFNA16IL24IFNA17IFNKIFNA8CCL1IL13IFNA13IL36AIFNL3CXCL1IL21IL15IFNA2IL2IL24TSLPIL1F10IL19IL36RNOSMTNFIL9IL26IFNL2IL10IL6IL25IFNA14IL7CSF1IL1AIFNL1IFNA7IL20EPOCCL28IFNW1LIFCSF2IL3IL27IL1RNIFNA1IL11IL22IFNA5IL31IL5CTF1IL1BIL37IFNA4IFNA6IL18IL33CNTFIL12BIL12AIL23AIL12BEBI3IL12AIFNL2IFNL3Cytokine stormIL2CSF3CSF2CXCL10IL-6IL-1BIL-8CCL2TNFIL-12IL-8MMP3CCL2TNFIL-12IL-1BMMP1IL-6ROSNF-kappa-BVEGFAMMP9TGFB1CXCL1CSF1AREGIL17FIL17AIL22CXCL9IFNGIFNA1Prostaglandin E2Prostaglandin I2Pro-inflammatory signalingAnti-inflammatory signalingIL15IL2IL36BIL36GLymphotoxin-alphaTNFSF13BTNFSF13IL17AIL17BIL17DIL17FIL17CIFNA10IFNA21IFNL1CSF3CSF2IL-6ChemokinesCCL2CCL3CCL3L3CCL4CCL4L2CCL5CCL13CCL7CCL8CCL11CCL14CCL15CCL16CCL17CCL18CCL19CCL20CCL21CCL22CCL23CCL24CCL25CCL27CCL26XCL1XCL2CXCL2CXCL3CXCL5CXCL6PPBPCXCL10CXCL11CXCL12CXCL16CXCL17CX3CL1PF4PF4V1CXCL8CXCL9CXCL13CXCL14Name: Overview of proinflammatory and profibrotic mediatorsOrganism: Homo sapiens


Description

Inflammatory cytokines leading to cytokine storm after NF-kappa-B and prostaglandin activation. KEGG pathway 05171 and a paper by Robb et al. was referenced for the pathway development.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Turner MD, Nedjai B, Hurst T, Pennington DJ; ''Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.''; Biochim Biophys Acta, 2014 PubMed Europe PMC Scholia
  2. Robb CT, Goepp M, Rossi AG, Yao C; ''Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19.''; Br J Pharmacol, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128722
Approved
view02:09, 21 February 2024EweitzEconomize layout
128721view01:58, 21 February 2024EweitzColor metabolites, standardize font, ecoonomize layout
120801view12:31, 10 January 2022DuyguddOntology Term : 'pro-inflammatory cytokine mediated pathway' added !
116868view20:50, 14 May 2021Marvin M2Added chemokines
116764view09:58, 12 May 2021Marvin M2Added cytokines
116697view18:36, 9 May 2021AriajadhavModified description
116696view18:31, 9 May 2021AriajadhavAdded references to Prostaglandin pathways
116695view18:27, 9 May 2021AriajadhavAdded Prostaglandin mediated cytokine release to pathway
116384view11:18, 6 May 2021RaatsSModified description
116383view11:17, 6 May 2021RaatsSchanged title format. capitalized letters.
116382view11:16, 6 May 2021RaatsSAdded upstream genes and metabolites
116381view11:14, 6 May 2021RaatsSNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AREGGeneProductENSG00000109321 (Ensembl)
CCL11GeneProductENSG00000172156 (Ensembl)
CCL13GeneProductENSG00000181374 (Ensembl)
CCL14GeneProductENSG00000276409 (Ensembl)
CCL15GeneProductENSG00000275718 (Ensembl)
CCL16GeneProductENSG00000275152 (Ensembl)
CCL17GeneProductENSG00000102970 (Ensembl)
CCL18GeneProductENSG00000275385 (Ensembl)
CCL19GeneProductENSG00000172724 (Ensembl)
CCL1GeneProductENSG00000108702 (Ensembl)
CCL20GeneProductENSG00000115009 (Ensembl)
CCL21GeneProductENSG00000137077 (Ensembl)
CCL22GeneProductENSG00000102962 (Ensembl)
CCL23GeneProductENSG00000274736 (Ensembl)
CCL24GeneProductENSG00000106178 (Ensembl)
CCL25GeneProductENSG00000131142 (Ensembl)
CCL2GeneProduct6347 (Entrez Gene)
CCL26GeneProductENSG00000006606 (Ensembl)
CCL27GeneProductENSG00000213927 (Ensembl)
CCL28GeneProductENSG00000151882 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CCL3GeneProductENSG00000277632 (Ensembl)
CCL3L3GeneProductENSG00000276085 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CCL4L2GeneProductENSG00000276070 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CCL7GeneProductENSG00000108688 (Ensembl)
CCL8GeneProductENSG00000108700 (Ensembl)
CNTFGeneProductENSG00000242689 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CSF3GeneProductENSG00000108342 (Ensembl)
CTF1GeneProductENSG00000150281 (Ensembl)
CX3CL1GeneProductENSG00000006210 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
CXCL11GeneProductENSG00000169248 (Ensembl)
CXCL12GeneProductENSG00000107562 (Ensembl)
CXCL13GeneProductENSG00000156234 (Ensembl)
CXCL14GeneProductENSG00000145824 (Ensembl)
CXCL16GeneProductENSG00000161921 (Ensembl)
CXCL17GeneProductENSG00000189377 (Ensembl)
CXCL1GeneProductENSG00000163739 (Ensembl)
CXCL2GeneProductENSG00000081041 (Ensembl)
CXCL3GeneProductENSG00000163734 (Ensembl)
CXCL5GeneProductENSG00000163735 (Ensembl)
CXCL6GeneProductENSG00000124875 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
CXCL9GeneProductENSG00000138755 (Ensembl)
EBI3GeneProductENSG00000105246 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IFNKGeneProductENSG00000147896 (Ensembl)
IFNL1GeneProductENSG00000182393 (Ensembl)
IFNL2GeneProductENSG00000183709 (Ensembl)
IFNL3GeneProductENSG00000197110 (Ensembl)
IFNW1GeneProductENSG00000177047 (Ensembl)
IL-12GeneProductIL12A (HGNC)
IL-1BGeneProductENSG00000125538 (Ensembl)
IL-6GeneProductENSG00000136244 (Ensembl)
IL-8GeneProductENSG00000169429 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL13GeneProductENSG00000169194 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL17AGeneProductENSG00000112115 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL17CGeneProductENSG00000124391 (Ensembl)
IL17DGeneProductENSG00000172458 (Ensembl)
IL17FGeneProductENSG00000112116 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL19GeneProductENSG00000142224 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1F10GeneProductENSG00000136697 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
IL20GeneProductENSG00000162891 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL22GeneProductENSG00000127318 (Ensembl)
IL22GeneProductIL22 (HGNC)
IL23AGeneProductENSG00000110944 (Ensembl)
IL24GeneProductENSG00000162892 (Ensembl)
IL25GeneProductENSG00000166090 (Ensembl)
IL26GeneProductENSG00000111536 (Ensembl)
IL27GeneProductENSG00000197272 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL31GeneProductENSG00000204671 (Ensembl)
IL33GeneProductENSG00000137033 (Ensembl)
IL36AGeneProductENSG00000136694 (Ensembl)
IL36BGeneProductENSG00000136696 (Ensembl)
IL36GGeneProductENSG00000136688 (Ensembl)
IL36RNGeneProductENSG00000136695 (Ensembl)
IL37GeneProductENSG00000125571 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL5GeneProductENSG00000113525 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL7GeneProductENSG00000104432 (Ensembl)
IL9GeneProductENSG00000145839 (Ensembl)
LIFGeneProductENSG00000128342 (Ensembl)
Lymphotoxin-alphaProteinP01374 (Uniprot-TrEMBL)
MMP1GeneProductENSG00000196611 (Ensembl)
MMP3GeneProductENSG00000149968 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NF-kappa-B ProteinD6RC45 (Uniprot-TrEMBL)
OSMGeneProductENSG00000099985 (Ensembl)
PF4GeneProductENSG00000163737 (Ensembl)
PF4V1GeneProductENSG00000109272 (Ensembl)
PPBPGeneProductENSG00000163736 (Ensembl)
Prostaglandin E2Metabolite15551 (ChEBI)
Prostaglandin I2Metabolite35121-78-9 (CAS)
ROSMetaboliteCHEBI:26523 (ChEBI)
SPP1GeneProductENSG00000118785 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TNFSF13BGeneProductENSG00000102524 (Ensembl)
TNFSF13GeneProductENSG00000161955 (Ensembl)
TSLPGeneProductENSG00000145777 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
XCL1GeneProductENSG00000143184 (Ensembl)
XCL2GeneProductENSG00000143185 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5095"
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