Cohesin complex - Cornelia de Lange syndrome (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none STAG2RAD21SMC1ASMC3SMC1ASMC3STAG2NIPBLMAU2RAD21SMC1ASMC3RAD21STAG2SMC1AChromatidMitotic Chromosome CohesionChromatid 1Centromere cohesinWAPL binding to PDS5 activates removal of cohesinTelophase/G1 phasePPP2R1APPP2R5CPPP2R5BPPP2R5APPP2CBPPP2CAPPP2R5EPTPAPPP2R1BPPP2R5DSororinSMC3SMC3PDS5BWAPLPDS5ASMC1ASMC3STAG2RAD21SororinHDAC8STAG2SeparinSororinAPCCDK1SMC1ASMC3SecurinSGO1S/G2 phaseChromatid 1Chromatid 2Prophase/MetaphaseSMC1ARAD21Chromatid 1Chromatid 2Metaphase/AnaphaseSMC1ASMC3RAD21STAG2Chromatid 1SororinPDS5BPDS5AWAPLSMC1ASMC3RAD21STAG2Chromatid 1Chromatid 2ESCO1ESCO2PDS5APDS5BChromatid 1Chromatid 2PLK1SororinAurora kinase BChromatid 1Chromatid 2PDS5BPDS5AAAChromatid 1Chromatid 2AASMC3HDAC8ALegendSMC3Anaphase I at centromeresMetaphase IIAnaphase IIChromatid 1Metaphase ISecurinAPCESCO2ESCO1SGO2PPP2R1APPP2R5CPPP2R5BPPP2R5APPP2CBPPP2CAPPP2R5EPTPAPPP2R1BPPP2R5DREC8REC8UnknownSeparinSeparinAPCUnknownSecurinHDAC8REC8Meiotic Chromosome CohesionSMC3SMC1BSTAG3REC8Chromatid 2SMC3SMC1BSTAG3REC8Chromatid 1Chromatid 2Anaphase I at chromatid armsSMC3SMC1BSTAG3REC8SMC3SMC1BSTAG3REC8SMC3SMC1BSTAG3REC8Chromatid 1Chromatid 2Chromatid 1Chromatid 2Chromatid 1Chromatid 2SMC3SMC1BSTAG3REC8Chromatid 1Chromatid 2ASMC3SMC3ASMC1BChromatidLegendSMC3SMC3STAG2Name: Cohesin complex - Cornelia de Lange syndromeOrganism: Homo sapiens


Description

Cohesin complex workings during mitotic and meiotic cell cycles.

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Quality Tags

Image:Unconnected.pngFix interactions
Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

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  1. Al-Jomah N, Mukololo L, Anjum A, Al Madadha M, Patel R; ''Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation''; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372117/, 2020 PubMed Europe PMC Scholia
  2. Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM; ''Dissociation of Cohesin from Chromosome Arms and Loss of Arm Cohesion during Early Mitosis Depends on Phosphorylation of SA2''; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1054881/, 2005 PubMed Europe PMC Scholia
  3. Liu J, Krantz ID; ''Cornelia de Lange syndrome, cohesin, and beyond''; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853897/, 2009 PubMed Europe PMC Scholia
  4. Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D; ''Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function''; https://pubmed.ncbi.nlm.nih.gov/26923589/, 2016 PubMed Europe PMC Scholia
  5. Ishiguro KI; ''The cohesin complex in mammalian meiosis.''; Genes Cells, 2019 PubMed Europe PMC Scholia
  6. Gabriela Whelan, Emanuel Kreidl, Gordana Wutz, Alexander Egner, Jan-Micheal Peters, Gregor Eichele; ''Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin''; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252581/, 2011 PubMed Europe PMC Scholia
  7. Tomoko Nishiyama, Martina M Sykora, Pim J Huis in 't Veld, Jan-Michael Peters; ''Aurora B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin''; https://pubmed.ncbi.nlm.nih.gov/23901111/, 2013 PubMed Europe PMC Scholia
  8. Zhang Q, Liu H; ''Functioning mechanisms of Shugoshin-1 in centromeric cohesion during mitosis.''; Essays Biochem, 2020 PubMed Europe PMC Scholia
  9. Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T, Lombardi PM, Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T, Krantz ID, Shirahige K; ''HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.''; Nature, 2012 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
129302
Approved
view13:44, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
119395view10:48, 27 June 2021EweitzOntology Term : 'Cornelia de Lange syndrome' added !
119394view10:48, 27 June 2021EweitzModified title
119107view12:36, 17 June 2021IrkilmezANew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
APCGeneProductENSG00000134982 (Ensembl)
Aurora kinase BProteinQ96GD4 (Uniprot-TrEMBL)
CDK1GeneProductENSG00000170312 (Ensembl)
ESCO1GeneProductENSG00000141446 (Ensembl)
ESCO2GeneProductENSG00000171320 (Ensembl)
HDAC8GeneProductENSG00000147099 (Ensembl)
MAU2GeneProductENSG00000129933 (Ensembl)
NIPBLGeneProductENSG00000164190 (Ensembl)
PDS5AGeneProductENSG00000121892 (Ensembl)
PDS5BGeneProductENSG00000083642 (Ensembl)
PLK1GeneProductENSG00000166851 (Ensembl)
PPP2CAGeneProductENSG00000113575 (Ensembl)
PPP2CBGeneProductENSG00000104695 (Ensembl)
PPP2R1AGeneProductENSG00000105568 (Ensembl)
PPP2R1BGeneProductENSG00000137713 (Ensembl)
PPP2R5AGeneProductENSG00000066027 (Ensembl)
PPP2R5BGeneProductPPP2R5B (HGNC)
PPP2R5CGeneProductENSG00000078304 (Ensembl)
PPP2R5DGeneProductENSG00000112640 (Ensembl)
PPP2R5EGeneProductENSG00000154001 (Ensembl)
PTPAGeneProductENSG00000119383 (Ensembl)
RAD21GeneProductENSG00000164754 (Ensembl)
REC8GeneProductENSG00000100918 (Ensembl) Phosphorylation of REC8 makes it more susceptible to separase cleavage
SGO1GeneProductENSG00000129810 (Ensembl)
SGO2GeneProductENSG00000163535 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SMC1BGeneProductENSG00000077935 (Ensembl)
SMC3GeneProductENSG00000108055 (Ensembl)
SMC3GeneProductSMC3 (HGNC)
STAG2GeneProductENSG00000101972 (Ensembl)
STAG3GeneProductENSG00000066923 (Ensembl)
SecurinProteinO95997 (Uniprot-TrEMBL)
SeparinProteinQ14674 (Uniprot-TrEMBL)
SororinProteinB5MBX0 (Uniprot-TrEMBL)
SororinProteinQ96FF9 (Uniprot-TrEMBL)
Unknown
WAPLGeneProductENSG00000062650 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5117"
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