Iron-sulfur cluster biogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Mitochondrial Fe-S proteinse-L-cysteineFXNNFS1LYRM4ISCUSFeFe[4Fe-4S] clusterISCUFDX1FDXRABCB7HSPA9HSCBGLRX5NUBP2NUBP1[4Fe-4S] clusterNARFCIAO1CIAO2BFXNNFU1NFS1ISCUFeFeCytosolicFe-S proteinsName: Iron-sulfur cluster biogenesisOrganism: Homo sapiens


Description

This pathway describes the biogenesis of iron-sulphur clusters. Iron-sulphur clusters bind to proteins and are essential components of respiratory electron transfer complexes as well as many other biological processes. This pathway was modeled based on Fig 2a from [Rouault and Tong](https://pubmed.ncbi.nlm.nih.gov/18606475/).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia
  2. Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137686
Approved
view05:13, 7 March 2025EgonwModified description
136735view03:16, 20 February 2025EweitzClear board dimension cache
136734view03:16, 20 February 2025EweitzEconomize layout
125997view18:20, 24 March 2023KhanspersOntology Term : 'regulatory pathway' added !
125989view18:12, 23 March 2023KhanspersModified description
125986view18:06, 23 March 2023Khansperslatest - updated xrefs
125985view18:04, 23 March 2023KhanspersReverted to version '17:47, 23 March 2023' by Khanspers
125984view18:03, 23 March 2023Khansperslatest - updated xrefs
125983view17:47, 23 March 2023KhanspersModified description
125982view17:31, 23 March 2023KhanspersModified description
125981view17:31, 23 March 2023Khanspersupdate with latest
120555view00:20, 15 December 2021KhanspersOntology Term : 'iron-sulfur cluster protein biogenesis pathway' added !
120554view00:19, 15 December 2021KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCB7GeneProduct22 (Entrez Gene)
CIAO1GeneProduct4682 (Entrez Gene)
CIAO2BGeneProduct51647 (Entrez Gene)
FDX1GeneProduct2230 (Entrez Gene)
FDXRGeneProduct2232 (Entrez Gene)
FXNGeneProduct2395 (Entrez Gene)
FeMetaboliteCHEBI:18248 (ChEBI)
GLRX5GeneProduct51218 (Entrez Gene)
HSCBGeneProduct150274 (Entrez Gene)
HSPA9GeneProduct3313 (Entrez Gene)
ISCUGeneProduct23479 (Entrez Gene)
L-cysteineMetaboliteCHEBI:17561 (ChEBI)
LYRM4GeneProduct57128 (Entrez Gene)
NARFGeneProduct26502 (Entrez Gene)
NFS1GeneProduct9054 (Entrez Gene)
NFU1GeneProduct27247 (Entrez Gene)
NUBP1GeneProduct4682 (Entrez Gene)
NUBP2GeneProduct10101 (Entrez Gene)
SMetaboliteCHEBI:26833 (ChEBI)
[4Fe-4S] clusterMetaboliteCHEBI:49883 (ChEBI)
e-MetaboliteCHEBI:10545 (ChEBI)

Annotated Interactions

No annotated interactions

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