Iron-sulfur cluster biogenesis (Homo sapiens)
From WikiPathways
Description
This pathway describes the biogenesis of iron-sulphur clusters. Iron-sulphur clusters bind to proteins and are essential components of respiratory electron transfer complexes as well as many other biological processes.
This pathway was modeled based on Fig 2a from [Rouault and Tong](https://pubmed.ncbi.nlm.nih.gov/18606475/).
Quality Tags
Ontology Terms
Bibliography
- Rouault TA, Tong WH; ''Iron-sulfur cluster biogenesis and human disease.''; Trends Genet, 2008 PubMed Europe PMC Scholia
- Friemel M, Marelja Z, Li K, Leimkühler S; ''The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1.''; Biochemistry, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
ABCB7 | GeneProduct | 22 (Entrez Gene) ![]() | |
CIAO1 | GeneProduct | 4682 (Entrez Gene) ![]() | |
CIAO2B | GeneProduct | 51647 (Entrez Gene) ![]() | |
FDX1 | GeneProduct | 2230 (Entrez Gene) ![]() | |
FDXR | GeneProduct | 2232 (Entrez Gene) ![]() | |
FXN | GeneProduct | 2395 (Entrez Gene) ![]() | |
Fe | Metabolite | CHEBI:18248 (ChEBI) ![]() | |
GLRX5 | GeneProduct | 51218 (Entrez Gene) ![]() | |
HSCB | GeneProduct | 150274 (Entrez Gene) ![]() | |
HSPA9 | GeneProduct | 3313 (Entrez Gene) ![]() | |
ISCU | GeneProduct | 23479 (Entrez Gene) ![]() | |
L-cysteine | Metabolite | CHEBI:17561 (ChEBI) ![]() | |
LYRM4 | GeneProduct | 57128 (Entrez Gene) ![]() | |
NARF | GeneProduct | 26502 (Entrez Gene) ![]() | |
NFS1 | GeneProduct | 9054 (Entrez Gene) ![]() | |
NFU1 | GeneProduct | 27247 (Entrez Gene) ![]() | |
NUBP1 | GeneProduct | 4682 (Entrez Gene) ![]() | |
NUBP2 | GeneProduct | 10101 (Entrez Gene) ![]() | |
S | Metabolite | CHEBI:26833 (ChEBI) ![]() | |
[4Fe-4S] cluster | Metabolite | CHEBI:49883 (ChEBI) ![]() | |
e- | Metabolite | CHEBI:10545 (ChEBI) ![]() |
Annotated Interactions
No annotated interactions