Arachidonic acid (AA, ARA) oxylipin metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none EXA4Trioxilin A315-keto-PGF2alphaTXA2HXA35,15-DiHETELOX5,6-DiHETrE11beta-PGF2alphaTetranor 12-HETEPGA25,12-DiHETE13,14-dihydro-15-keto-PGE25(6)-EpETrE6-keto-PGF1alphaPGD2delta(12)-PGJ22,3-dinor-TXB211-dehydro-TXB28(9)-EpETrE15-deoxy-delta(12,14)-PGJ211-oxo-ETE16-HETEPGE214,15-DiHETrECOX1ASA9-HETELTE415-epi-LXA420-carboxy-LTB415-keto-PGE219-HETE12-HHTrE12-oxo-ETE11(12)-EpETrE8-HpETELTB4COX2LTA4PGJ215-epi-LXB4tetranor-TXB28-oxo-ETE15-keto-PGD2TXB2EXE412-HpETE15(R)-HpETE8-HETE15-HETE8,15-DiHETE5-HpETE15-oxo-ETE13,14-dihydro-15-keto-PGD2LXB4Trioxilin B313,14-dihydro-15-keto-PGF2alphaPGB2LXA4EXC4LTF411-HETE8,9-DiHETrECOX220-HETE12-HETEPGI212,20-DiHETECYP9-HpETE11-HpETEEPHX2HXB315-HpETEARA5,20-DiHETE5-oxo-ETELTD4PGH2CYP omega-hydrolasePGF2alphaEXD414(15)-EpETrELTC45-HETE17-HETE18-HETE11,12-DiHETrE20-hydroxy-LTB4TBXAS1tetranor-PGEMΔ12-PGD215d-PGD2Name: Arachidonic acid (AA, ARA) oxylipin metabolismOrganism: Homo sapiens


Description

Arachidonic acid (AA or ARA) oxlipin metabolism

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : classic metabolic pathway
 

Bibliography

  1. Smith WL, Urade Y, Jakobsson PJ; ''Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.''; Chem Rev, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135483
Approved
view22:20, 17 September 2024LcayerAdded PGD2 metabolites for 15d-PGD2 synthesis
124435view13:59, 27 October 2022LcayerAdded metabolite tetranor 12-HETE
120635view21:15, 21 December 2021EweitzModified title
120633view21:05, 21 December 2021LcayerOntology Term : 'eicosanoid metabolic pathway' added !
120630view20:16, 21 December 2021LcayerNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
11(12)-EpETrEMetabolite5283204 (PubChem-compound)
11,12-DiHETrEMetaboliteCHEBI:63969 (ChEBI)
11-HETEMetaboliteQ27140010 (Wikidata)
11-HpETEMetabolite5283174 (PubChem-compound)
11-dehydro-TXB2Metabolite5280891 (PubChem-compound)
11-oxo-ETEMetaboliteQ27162742 (Wikidata)
11beta-PGF2alphaMetabolite5280886 (PubChem-compound)
12,20-DiHETEMetaboliteHMDB60105 (HMDB)
12-HETEMetaboliteHMDB06111 (HMDB)
12-HHTrEMetabolite5312765 (PubChem-compound)
12-HpETEMetaboliteCHEBI:15626 (ChEBI)
12-oxo-ETEMetaboliteCHEBI:34151 (ChEBI)
13,14-dihydro-15-keto-PGD2Metabolite5283036 (PubChem-compound)
13,14-dihydro-15-keto-PGE2Metabolite5280711 (PubChem-compound)
13,14-dihydro-15-keto-PGF2alphaMetabolite5283039 (PubChem-compound)
14(15)-EpETrEMetabolite5283205 (PubChem-compound)
14,15-DiHETrEMetaboliteCHEBI:63966 (ChEBI)
15(R)-HpETEMetabolite10042663 (PubChem-compound)
15-HETEMetaboliteCHEBI:64017 (ChEBI)
15-HpETEMetaboliteHMDB62688 (HMDB)
15-deoxy-delta(12,14)-PGJ2Metabolite5311211 (PubChem-compound)
15-epi-LXA4Metabolite9841438 (PubChem-compound)
15-epi-LXB4MetaboliteCHEBI:63991 (ChEBI)
15-keto-PGD2Metabolite5280727 (PubChem-compound)
15-keto-PGE2Metabolite5280719 (PubChem-compound)
15-keto-PGF2alphaMetabolite5280887 (PubChem-compound)
15-oxo-ETEMetaboliteCHEBI:15559 (ChEBI)
15d-PGD2MetaboliteHMDB0060046 (HMDB)
16-HETEMetaboliteQ27070786 (Wikidata)
17-HETEMetaboliteHMDB12598 (HMDB)
18-HETEMetaboliteCHEBI:63579 (ChEBI)
19-HETEMetaboliteQ27132956 (Wikidata)
2,3-dinor-TXB2Metabolite5283138 (PubChem-compound)
20-HETEMetaboliteCHEBI:34306 (ChEBI)
20-carboxy-LTB4Metabolite5280877 (PubChem-compound)
20-hydroxy-LTB4Metabolite5280745 (PubChem-compound)
5(6)-EpETrEMetabolite5283202 (PubChem-compound)
5,12-DiHETEMetaboliteCHEBI:15647 (ChEBI)
5,15-DiHETEMetaboliteCHEBI:91286 (ChEBI)
5,20-DiHETEMetaboliteHMDB62614 (HMDB)
5,6-DiHETrEMetaboliteCHEBI:63974 (ChEBI)
5-HETEMetaboliteHMDB11134 (HMDB)
5-HpETEMetabolite5283171 (PubChem-compound)
5-oxo-ETEMetabolite5283159 (PubChem-compound)
6-keto-PGF1alphaMetabolite5280888 (PubChem-compound)
8(9)-EpETrEMetabolite5283203 (PubChem-compound)
8,15-DiHETEMetaboliteHMDB10219 (HMDB)
8,9-DiHETrEMetaboliteCHEBI:63970 (ChEBI)
8-HETEMetaboliteHMDB04679 (HMDB)
8-HpETEMetabolite6438881 (PubChem-compound)
8-oxo-ETEMetaboliteQ27145567 (Wikidata)
9-HETEMetaboliteCHEBI:72785 (ChEBI)
9-HpETEMetaboliteCHEBI:78732 (ChEBI)
ARAMetaboliteHMDB01043 (HMDB)
ASAMetaboliteCHEBI:15365 (ChEBI)
COX1GeneProduct5742 (Entrez Gene)
COX2GeneProduct5743 (Entrez Gene)
CYPGeneProduct
CYP omega-hydrolaseGeneProduct
EPHX2GeneProductENSG00000120915 (Ensembl)
EXA4MetaboliteCHEBI:63983 (ChEBI)
EXC4MetaboliteCHEBI:63984 (ChEBI)
EXD4MetaboliteCHEBI:63985 (ChEBI)
EXE4MetaboliteCHEBI:63986 (ChEBI)
HXA3MetaboliteCHEBI:36190 (ChEBI)
HXB3MetaboliteCHEBI:34784 (ChEBI)
LOXGeneProduct
LTA4Metabolite5280383 (PubChem-compound)
LTB4MetaboliteCHEBI:15647 (ChEBI)
LTC4MetaboliteCHEBI:16978 (ChEBI)
LTD4MetaboliteCHEBI:28666 (ChEBI)
LTE4MetaboliteCHEBI:15650 (ChEBI)
LTF4MetaboliteCHEBI:27491 (ChEBI)
LXA4MetaboliteQ27082450 (Wikidata)
LXB4MetaboliteCHEBI:6499 (ChEBI)
PGA2MetaboliteCHEBI:133370 (ChEBI)
PGB2Metabolite5280881 (PubChem-compound)
PGD2MetaboliteCHEBI:15555 (ChEBI)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGF2alphaMetaboliteCHEBI:15553 (ChEBI)
PGH2MetaboliteCHEBI:15554 (ChEBI)
PGI2MetaboliteCHEBI:15552 (ChEBI)
PGJ2Metabolite5280884 (PubChem-compound)
TBXAS1GeneProduct6916 (Entrez Gene)
TXA2MetaboliteCHEBI:15627 (ChEBI)
TXB2MetaboliteCHEBI:28728 (ChEBI)
Tetranor 12-HETEMetaboliteHMDB60055 (HMDB)
Trioxilin A3Metabolite5283208 (PubChem-compound)
Trioxilin B3MetaboliteCHEBI:35032 (ChEBI)
delta(12)-PGJ2Metabolite5280885 (PubChem-compound)
tetranor-PGEMMetabolite161468 (PubChem-compound)
tetranor-TXB2Metabolite
Δ12-PGD2Metabolite64072-89-5 (CAS)

Annotated Interactions

No annotated interactions

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