Hippocampal synaptogenesis and neurogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Regulation of multiplepostsynaptic and presynaptic proteins through phosphorylation(e.g. neurotransmitter synthesis, cytoskeletal regulation, calcium channelregulation)CytokinesGrowth factorsCaMKIIDRD1ATPCa2+Thyroxine (T4)PRKCAVoltage-gated Ca2+ channelAMPANMDAcAMPCREB1Ca2+Ca2+Ca2+Ca2+Ca2+Ca2+Na+K+CALM1CAMK2ACAMK2BCAMKK1CAMKK2CaMKKCAMK4CAMK4PRKCATrkBMAPK14MAPK/ERKRSKRSKRPS6KA5Adult hippocampal neurogenesisMemory cognition(spatial memory, recognition memory, fear memory,pattern discrimination)Triiodothyronine (T3)Thyroxine (T4)DIO2NRXN1NRXN2NRXN3SYT2SYT12Ca2+ dependent synaptic remodelingBDNFNCAM1PRLBCL2NGFCCND2Ca2+ dependent expression of neurogenic genesHNRNPLHippocampal neuronPPARGC1ARegulation of calcium homeostasisin neuronal cells. Influences brain developmentName: Hippocampal synaptogenesis and neurogenesisOrganism: Homo sapiens


Description

Cognitive function and the consolidation of memory through hippocampal synaptogenesis and neurogenesis and the role of thyroxine.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Krebs J; ''The Influence of Thyroid Hormone on Ca2+Signaling Pathways During Embryonal Development.''; Curr Top Med Chem, 2021 PubMed Europe PMC Scholia
  2. Ortega-Martínez S; ''A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis.''; Front Mol Neurosci, 2015 PubMed Europe PMC Scholia
  3. Krebs J; ''Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.''; Biochim Biophys Acta Mol Cell Res, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134518
Approved
view12:39, 22 July 2024EweitzImprove contrast for better readability
134517view12:38, 22 July 2024EweitzImprove contrast for better readability
123335view19:22, 16 July 2022AlexanderPicoOntology Term : 'hippocampal neuron' added !
123334view19:22, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway' added !
123333view19:22, 16 July 2022AlexanderPicoOntology Term : 'regulatory pathway' added !
123332view19:22, 16 July 2022AlexanderPicoOntology Term : 'synaptic differentiation pathway' added !
123331view19:21, 16 July 2022AlexanderPicoOntology Term : 'signaling pathway pertinent to development' added !
123330view19:19, 16 July 2022AlexanderPicoModified title
123329view19:19, 16 July 2022AlexanderPicoModified description
122750view09:33, 9 May 2022CMalyarFixed unconnected arrow
122749view09:32, 9 May 2022CMalyarModified arrow
122748view09:25, 9 May 2022CMalyarAdded anchor
122732view20:19, 6 May 2022CMalyarModified identifiers
122731view20:19, 6 May 2022CMalyarModified identifiers
122730view13:38, 6 May 2022CMalyarAddition of genes downstream of T3 (Neurexin, SYT2,SYT12, PMCA1a, HNRNPL). New references.
122705view10:08, 4 May 2022EgonwNormalized the Ensembl data source
122699view14:35, 3 May 2022CMalyar
122698view14:35, 3 May 2022CMalyar
122697view14:33, 3 May 2022CMalyarNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AMPA ComplexR-HSA-9620484 (Reactome)
ATPMetabolite30616 (ChEBI)
BCL2ProteinENSG00000171791 (Ensembl)
BDNF ProteinENSG00000176697 (Ensembl)
CALM1 ProteinENSG00000198668 (Ensembl)
CAMK2A ProteinENSG00000070808 (Ensembl)
CAMK2B ProteinENSG00000058404 (Ensembl)
CAMK4 ProteinENSG00000152495 (Ensembl)
CAMK4 ProteinHGNC:1464 (HGNC)
CAMKK1 ProteinENSG00000004660 (Ensembl)
CAMKK2 ProteinENSG00000110931 (Ensembl)
CCND2 ProteinENSG00000118971 (Ensembl)
CREB1ProteinP16220 (Uniprot-TrEMBL)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DIO2 ProteinENSG00000211448 (Ensembl)
DRD1 GeneProductENSG00000184845 (Ensembl)
HNRNPL ProteinENSG00000104824 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
MAPK/ERK ProteinENSG00000100030 (Ensembl)
MAPK14ProteinENSG00000112062 (Ensembl)
NCAM1 ProteinENSG00000149294 (Ensembl)
NGF ProteinENSG00000134259 (Ensembl)
NMDA ComplexR-HSA-884990 (Reactome)
NRXN1 ProteinENSG00000179915 (Ensembl)
NRXN2 ProteinENSG00000110076 (Ensembl)
NRXN3 ProteinENSG00000021645 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
PPARGC1AProteinENSG00000109819 (Ensembl)
PRKCA ProteinENSG00000154229 (Ensembl)
PRKCA ProteinHGNC:9393 (HGNC)
PRLProteinENSG00000172179 (Ensembl)
RPS6KA5ProteinENSG00000100784 (Ensembl)
RSK ProteinENSG00000117676 (Ensembl)
SYT12ProteinENSG00000173227 (Ensembl)
SYT2 ProteinENSG00000143858 (Ensembl)
Thyroxine (T4)MetaboliteHMDB0000248 (HMDB)
Triiodothyronine (T3)Metabolite5707 (Chemspider)
TrkBGeneProductW8VY28 (Uniprot-TrEMBL)
Voltage-gated Ca2+ channel ComplexR-HSA-210378 (Reactome)
cAMPMetabolite17489 (ChEBI)

Annotated Interactions

No annotated interactions

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